{"id":18240,"date":"2002-09-07T00:00:00","date_gmt":"2002-09-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/citotoxicidad-y-genotoxicidad-del-almizcle-ambrette\/"},"modified":"2002-09-07T00:00:00","modified_gmt":"2002-09-07T00:00:00","slug":"citotoxicidad-y-genotoxicidad-del-almizcle-ambrette","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/citotoxicidad-y-genotoxicidad-del-almizcle-ambrette\/","title":{"rendered":"Citotoxicidad y genotoxicidad del almizcle \u00abambrette\u00bb"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Consuelo Valverde Quilez <\/strong><\/h2>\n<p>Los compuestos derivados del almizcle tienen un amplio uso en la vida cotidiana (detergentes, cremas, perfumes, tabaco de mascar y en productos alimentarios como dulces y bebidas). Se han encontrado incluso en la leche materna. Tras realizar estudios en distintos organismos vivos, se ha comprobado su toxicidad, ocasionando en ratas atrofia muscular con par\u00e1lisis y retraso en el crecimiento, cambios neuropatol\u00f3gicos e ictericia.  dada la repercusi\u00f3n de los almizcles, nosotros hemos seleccionado el almizcle ambrette (6-ter-butil-3-metil-2,4-dinitroanisol) por ser uno de los m\u00e1s utilizados.  nuestras investigaciones se han centrado en estudios genot\u00f3xicos, seleccionando el ensayo de reversi\u00f3n mutag\u00e9nica en s. Typhimurium y e. Coli. Siguiendo las normas que dicta el diario oficial de las comunidades europeas y citot\u00f3xicos, en c\u00e9lulas gonadales de trucha arcoiris.  los resultados obtenidos nos indican que el musk \u00abambrette\u00bb no es t\u00f3xico a ninguna de las concentraciones ensayadas excepto en la cepa ta97 de s. typhimurium a la mayor concentraci\u00f3n ensayada y en presencia de activaci\u00f3n metab\u00f3lica.  el efecto mutag\u00e9nico observado en s. Thyphimurium cepa ta 100 a la m\u00e1xima concentraci\u00f3n empleada y con activaci\u00f3n metab\u00f3lica, no se observa en las otras concentraciones empleadas, o al utilizar otras cepas de la misma especie o de otra distinta como es d. Coli.  los valores de citotoxicidad (nr50 y kb50) del almizcle \u00abambrette\u00bb han sido muy similares en los dos ensayos realizados de viabilidad celular y prote\u00ednas totales.  consecuentemente nosotros apoyamos la eliminaci\u00f3n del musk \u00abambrette\u00bb de los productos de consumo.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Citotoxicidad y genotoxicidad del almizcle \u00abambrette\u00bb<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Citotoxicidad y genotoxicidad del almizcle \u00abambrette\u00bb <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Consuelo Valverde Quilez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 09\/07\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>F\u00e9lix Sanz Barrera<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Ruiz amil <\/li>\n<li> Hern\u00e1ndez antolin m. teresa (vocal)<\/li>\n<li> Fern\u00e1ndez san Juan  pedro (vocal)<\/li>\n<li>vicente Calderon pascual (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Consuelo Valverde Quilez Los compuestos derivados del almizcle tienen un amplio uso en la vida cotidiana (detergentes, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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