{"id":18320,"date":"2002-11-07T00:00:00","date_gmt":"2002-11-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-citotoxicos-y-mitogenicos-del-tnf-en-fibroblastos-murinos\/"},"modified":"2002-11-07T00:00:00","modified_gmt":"2002-11-07T00:00:00","slug":"efectos-citotoxicos-y-mitogenicos-del-tnf-en-fibroblastos-murinos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/efectos-citotoxicos-y-mitogenicos-del-tnf-en-fibroblastos-murinos\/","title":{"rendered":"Efectos citot\u00f3xicos y mitog\u00e9nicos del tnf en fibroblastos murinos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ren\u00e9 Rodr\u00edguez Gonz\u00e1lez <\/strong><\/h2>\n<p>El tnf puede inducir tanto la muerte como la proliferaci\u00f3n celular seg\u00fan el tipo celular y las distintas condiciones ambientales. En el presente trabajo se aborda el estudio de ambos efectos en un mismo tipo celular, los fibroblastos murinos no transformados nih 3t3. Estas c\u00e9lulas no son sensibles al efecto t\u00f3xico del tnf a menos que se encuentre inhibida la expresi\u00f3n g\u00e9nica. As\u00ed, el tratamiento con tnf en presencia de actinomicina d (act-d) induce un mecanismo apopt\u00f3tico en el que la mitocondria es esencial. la inhibici\u00f3n general de las caspasas provoca el cambio a un mecanismo necr\u00f3tico. En c\u00e9lulas sincronizadas en fase g0, el tnf induce la s\u00edntesis de adn; sin embargo, simult\u00e1neamente provoca la muerte de las c\u00e9lulas que no pueden proliferar. Los factores de crecimiento del suero evitan la aparici\u00f3n de este efecto t\u00f3xico. La muerte celular inducida por tnf y act-d se produce en todas las fases del ciclo celular y la parada en distintos puntos del ciclo sensibiliza las c\u00e9lulas al efecto t\u00f3xico del tnf, eliminando el requerimiento de act-d. Las se\u00f1ales apopt\u00f3ticas inducidas por el tnf en c\u00e9lulas paradas en fase g1\/s son an\u00e1logas a las inducidas en c\u00e9lulas no sicronizadas por tnf y act-d excepto que la p\u00e9rdida de potencial mitocondrial es m\u00e1s tard\u00eda en las primeras.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos citot\u00f3xicos y mitog\u00e9nicos del tnf en fibroblastos murinos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos citot\u00f3xicos y mitog\u00e9nicos del tnf en fibroblastos murinos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ren\u00e9 Rodr\u00edguez Gonz\u00e1lez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Oviedo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 11\/07\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Pedro S\u00e1nchez Lazo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Carlos Lopez otin <\/li>\n<li>Manuel Freire rama (vocal)<\/li>\n<li>Javier Le\u00f3n serrano (vocal)<\/li>\n<li>Jos\u00e9 Alberto Orfao de matos correia e vale (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ren\u00e9 Rodr\u00edguez Gonz\u00e1lez El tnf puede inducir tanto la muerte como la proliferaci\u00f3n celular seg\u00fan el tipo [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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