{"id":18336,"date":"2002-11-07T00:00:00","date_gmt":"2002-11-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-del-modelo-transgenico-condicional-de-la-enfermedad-de-huntington-estudios-in-vivo-y-en-cultivos-primarios\/"},"modified":"2002-11-07T00:00:00","modified_gmt":"2002-11-07T00:00:00","slug":"caracterizacion-del-modelo-transgenico-condicional-de-la-enfermedad-de-huntington-estudios-in-vivo-y-en-cultivos-primarios","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/caracterizacion-del-modelo-transgenico-condicional-de-la-enfermedad-de-huntington-estudios-in-vivo-y-en-cultivos-primarios\/","title":{"rendered":"Caracterizaci\u00f3n del modelo transg\u00e9nico condicional de la enfermedad de huntington: estudios in vivo y en cultivos primarios"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Mart\u00edn Aparicio M. Ester <\/strong><\/h2>\n<p>La enfermedad de huntington es una de las nueve enfermedades neurol\u00f3gicas causadas por una mutaci\u00f3n de expansi\u00f3n de tripletes de cag codificantes para secuencias de poliglutamina. Afecta al 3-7 por 100.000 de la poblaci\u00f3n descendiente de europa occidental y su sintomatolog\u00eda abarca trastornos de tipo motor (corea y rigidez entre otros), cognitivo (demencia subcortical) y psicol\u00f3gico (irritabilidad y depresi\u00f3n entre otros), que terminan con la muerte del individuo. La neuropatolog\u00eda de la enfermedad de huntington es extremadamente restringida, con una marcada atrofia del estriado y en menor medida de la corteza cerebral. Microsc\u00f3picamente, la patolog\u00eda estriatal est\u00e1 caracterizada por p\u00e9rdida neuronal, gliosis y presencia de agregados proteicos. Desde que en el a\u00f1o 1872 el doctor george huntington describiera por primera vez la enfermedad, ha habido m\u00faltiples avances en el conocimiento de la misma.  el descubrimiento del gen responsable de la enfermedad (el de la huntingtina) en el a\u00f1o 1993 ha dado lugar a la generaci\u00f3n de m\u00faltiples modelos in vitro, celulares, y animales que han permitido ahondar en las bases moleculares de esta neuropatolog\u00eda. En base a estos estudios han surgido varias l\u00edneas de investigaci\u00f3n que intentan explicar el mecanismo por el cual la huntingtina (htt) con la poliglutamina expandida provoca la neuropatolog\u00eda.  en este trabajo hemos pretendido ahondar en los mecanismos moleculares implicados en la patog\u00e9nesis de la enfermedad mediante la caracterizaci\u00f3n de un modelo transg\u00e9nico condicional de la enfermedad de huntington (hd94). los ratones hd94 expresan el ex\u00f3n 1 de la htt con un tramo de 94 glutaminas de un modo condicional, lo que permite explorar la posible reversibilidad de la neuropatolog\u00eda y la sintomatolog\u00eda. En la caracterizaci\u00f3n inicial del modelo, los agregados y la sintomatolog\u00eda revirtieron en paralelo por completo, impidiendo as\u00ed descartar o confirmar que los agregados fu<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizaci\u00f3n del modelo transg\u00e9nico condicional de la enfermedad de huntington: estudios in vivo y en cultivos primarios<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizaci\u00f3n del modelo transg\u00e9nico condicional de la enfermedad de huntington: estudios in vivo y en cultivos primarios <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Mart\u00edn Aparicio M. Ester <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 11\/07\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Javier Lucas Lozano<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jes\u00fas Avila de grado <\/li>\n<li>Jos\u00e9 ramon Naranjo orovio (vocal)<\/li>\n<li>david Mu\u00f1oz Garc\u00eda (vocal)<\/li>\n<li>jordi Alberch i vie (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mart\u00edn Aparicio M. Ester La enfermedad de huntington es una de las nueve enfermedades neurol\u00f3gicas causadas por [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[849,36483,36606,160,115,35,9,9399,965,156,17],"tags":[56939,3041,38170,56938,14321,56937],"class_list":["post-18336","post","type-post","status-publish","format-standard","hentry","category-biologia-celular","category-biologia-molecular","category-biologia-molecular-de-microorganismos","category-bioquimica","category-bioquimica-molecular","category-ciencias-de-la-vida","category-ciencias-medicas","category-cultivo-celular","category-neuropatologia","category-patologia","category-quimica","tag-david-munoz-garcia","tag-jesus-avila-de-grado","tag-jordi-alberch-i-vie","tag-jose-javier-lucas-lozano","tag-jose-ramon-naranjo-orovio","tag-martin-aparicio-m-ester"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/18336","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=18336"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/18336\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=18336"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=18336"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=18336"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}