{"id":18361,"date":"2002-12-07T00:00:00","date_gmt":"2002-12-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-farmacologico-de-derivados-glicosilados-de-dopamina-como-potenciales-agentes-antiparkinsonianos\/"},"modified":"2002-12-07T00:00:00","modified_gmt":"2002-12-07T00:00:00","slug":"estudio-farmacologico-de-derivados-glicosilados-de-dopamina-como-potenciales-agentes-antiparkinsonianos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-farmacologico-de-derivados-glicosilados-de-dopamina-como-potenciales-agentes-antiparkinsonianos\/","title":{"rendered":"Estudio farmacol\u00f3gico de derivados glicosilados de dopamina como potenciales agentes antiparkinsonianos"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Montenegro Navarro Gisela Yasm\u00edn <\/strong><\/h2>\n<p>El tratamiento de la enfermedad de parkinson (ep), al igual que otros des\u00f3rdenes neurol\u00f3gicos, cr\u00f3nicos o agudos, se ve limitado por la presencia de la barrera hematoencef\u00e1lica (bhe), que a\u00edsla al cerebro de la circulaci\u00f3n sist\u00e9mica permitiendo el paso de unas pocas mol\u00e9culas requeridas para mantener la homeostasis e impidiendo el paso de la mayor\u00eda de las sustancias ex\u00f3genas.  debido a los inconvenientes que presentan las t\u00e9cnicas m\u00e1s utilizadas para la vehiculizaci\u00f3n de compuestos al cerebro (administraci\u00f3n intracerebral, lipidizaci\u00f3n de las mol\u00e9culas), cada vez, despierta mayor inter\u00e9s la utilizaci\u00f3n de alguno de los varios sistemas fisiol\u00f3gicos presentes en la bhe con el objeto de vehiculizar compuestos al cerebro.  te\u00f3ricamente, los an\u00e1logos de glucosa son los mejores candidatos para el transporte a trav\u00e9s de la bhe, ya que el transportador de hexosas (glut-1), es el que cuenta con mayor capacidad, en vista de los grandes e ininterrumpidos requerimientos de glucosa que tiene el cerebro humano (10 veces su peso por minuto), con el fin de generar atp en las cantidades necesarias para mantener la transmisi\u00f3n normal de los impulsos nerviosos, estim\u00e1ndose el consumo cerebral de glucosa en cerca del 2% del peso corporal total y en casi el 30% del consumo total de glucosa del organismo (dick et al., 1984; la manna y harik, 1985).  en vista de la antes expuesto, y dando un enfoque totalmente innovador, se sintetizaron varios derivados glicoconjugados de dopamina, siendo el objetivo fundamental del presente estudio el de determinar la capacidad que tienen estos compuestos para actuar como eficaces prof\u00e1rmacos antiparkinsonianos en animales de experimentaci\u00f3n y en otras varias t\u00e9cnicas relacionadas tanto ex vivo como in vitro.  en los estudios en ratas reserpinizadas v\u00edas intraperitoneal se observa que de los compuestos ensayados a diferentes dosis (glico 40p1, glico 40p2, cf-44, cf-84, cf-85, cf-86 y cf-87) s\u00f3l<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio farmacol\u00f3gico de derivados glicosilados de dopamina como potenciales agentes antiparkinsonianos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio farmacol\u00f3gico de derivados glicosilados de dopamina como potenciales agentes antiparkinsonianos <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Montenegro Navarro Gisela Yasm\u00edn <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 12\/07\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Fontenla Gil Jos\u00e9 Angel<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Mar\u00eda Calleja suarez <\/li>\n<li>alfonso Velasco martin (vocal)<\/li>\n<li>ofelia Nieto (vocal)<\/li>\n<li>Jos\u00e9 Luis Labandeira garcia (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Montenegro Navarro Gisela Yasm\u00edn El tratamiento de la enfermedad de parkinson (ep), al igual que otros des\u00f3rdenes [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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