{"id":18388,"date":"2002-12-07T00:00:00","date_gmt":"2002-12-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/valor-pronostico-de-la-apoptosis-y-de-los-genes-relacionados-con-la-misma-p-53-bcl-2-y-bax-en-el-carcinoma-de-celulas-escamosas-de-la-cavidad-oral\/"},"modified":"2002-12-07T00:00:00","modified_gmt":"2002-12-07T00:00:00","slug":"valor-pronostico-de-la-apoptosis-y-de-los-genes-relacionados-con-la-misma-p-53-bcl-2-y-bax-en-el-carcinoma-de-celulas-escamosas-de-la-cavidad-oral","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/valor-pronostico-de-la-apoptosis-y-de-los-genes-relacionados-con-la-misma-p-53-bcl-2-y-bax-en-el-carcinoma-de-celulas-escamosas-de-la-cavidad-oral\/","title":{"rendered":"Valor pron\u00f3stico de la apoptosis y de los genes relacionados con la misma: p-53, bcl-2 y bax en el carcinoma de c\u00e9lulas escamosas de la cavidad oral"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Sonsoles Olay Garc\u00eda <\/strong><\/h2>\n<p>Objetivos  1,- estudiar la relaci\u00f3n existente entre la apoptosis y tres genes relacionados con la misma: p-53, bcl-2 y bax.  2,- evaluar la relaci\u00f3n entre la apoptosis, los genes p-53, bcl-2 y bax y las variables cl\u00ednicas e histol\u00f3gicas de los carcinomas de c\u00e9lulas escamosas de la boca.  3,- estudiar la supervivencia de los pacientes con carcinoma escamoso de la boca en funci\u00f3n de las variables cl\u00ednicas, histol\u00f3gicas e inmunohistoqu\u00edmicas investigadas.  dise\u00f1o  se ha realizado un estudio anal\u00edtico observacional de car\u00e1cter prospectivo. la muestra estaba constituida por 91 enfermos diagn\u00f3sticados e intervenidos de carcinoma escamoso oral. Las variables cl\u00ednicas e histol\u00f3gicas investigadas fueron: edad, sexo, localizaci\u00f3n, tama\u00f1o tumoral, grado de afectaci\u00f3n granglionar, estadio tnm, estado del paciente al final del estudio, y grado de diferenciaci\u00f3n. el seguimiento m\u00ednimo de los casos fue de 6 meses. Para el an\u00e1lisis inmunohistoqu\u00edmico se utilizaron anticuerpos para la p-53, bcl-2 y bax mediante el m\u00e9todo en visi\u00f3n y\/o lsab. Para el estudio de las apoptosis se utiliz\u00f3 el procedimiento tunel, cuantific\u00e1ndose dos variables; apoptosis e \u00edndice apopt\u00f3tico. En el an\u00e1lisis inferencial se emplearon pruebas param\u00e9tricas y no param\u00e9tricas. se consideraron diferencias significativas aquellas en las que el valor de p&lt;0,05. El estudio de la supervivencia se llev\u00f3 a cabo con los m\u00e9todos kaplan-meier, actuarial, y regresi\u00f3n de riesgos proporcionados de cox.  resultados  la edad media de los enfermos fue de 60 a\u00f1os. El 76,9% de los pacientes eran varones. Lengua y suelo de la boca fueron las localizaciones de mayor incidencia. La mayor parte de los casos eran t2 \u00f3 t4, sin afectaci\u00f3n ganglionar en el momento del tratamiento. La mayor parte de los pacientes (51 enfermos) se filiaron en los estadios tnm iii y iva. La inmunopositividad frente a, bcl-2 y bax(+++) se observ\u00f3 respectivamente en el 13,2% y 2,2% de<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Valor pron\u00f3stico de la apoptosis y de los genes relacionados con la misma: p-53, bcl-2 y bax en el carcinoma de c\u00e9lulas escamosas de la cavidad oral<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Valor pron\u00f3stico de la apoptosis y de los genes relacionados con la misma: p-53, bcl-2 y bax en el carcinoma de c\u00e9lulas escamosas de la cavidad oral <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Sonsoles Olay Garc\u00eda <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Oviedo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 12\/07\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Vicente Rodr\u00edguez Juan  Carlos De<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  L\u00f3pez-arranz arranz Juan  sebasti\u00e1n <\/li>\n<li> Vega \u00e1lvarez Jos\u00e9 Antonio (vocal)<\/li>\n<li>agustin julio Antonio  del Ca\u00f1izo fernandez roldan (vocal)<\/li>\n<li>gonzalo Hern\u00e1ndez vallejo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Sonsoles Olay Garc\u00eda Objetivos 1,- estudiar la relaci\u00f3n existente entre la apoptosis y tres genes relacionados con [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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