{"id":18406,"date":"2002-12-07T00:00:00","date_gmt":"2002-12-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-de-la-maprotilina-sobre-la-evitacion-inhibitoria-en-ratones-machos-y-hembras\/"},"modified":"2002-12-07T00:00:00","modified_gmt":"2002-12-07T00:00:00","slug":"efectos-de-la-maprotilina-sobre-la-evitacion-inhibitoria-en-ratones-machos-y-hembras","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/psicologia\/efectos-de-la-maprotilina-sobre-la-evitacion-inhibitoria-en-ratones-machos-y-hembras\/","title":{"rendered":"Efectos de la maprotilina sobre la evitaci\u00f3n inhibitoria en ratones machos y hembras"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Martos Mula Ana Josefa <\/strong><\/h2>\n<p>Los antidepresivos constituyen un grupo de psicof\u00e1rmacos que son consumidos a gran escala debido a su uso en la depresi\u00f3n mayor, trastornos cr\u00f3nicos de ansiedad, y en otros cuadros cl\u00ednicos. Muchos de estos antidepresivos tienen efectos adversos sobre la memoria. Diversos autores han relacionado estos efectos con la acci\u00f3n anticolin\u00e9rgica que gran parte de ellos poseen.  el objetivo del presente trabajo fue estudiar el efecto de la maprotilina sobre la memoria en ratones. Este antidepresivo de amplio uso cl\u00ednico es inhibidor de la recaptaci\u00f3n de noradrenalina y tambi\u00e9n produce un considerable bloqueo de los receptores colin\u00e9rgicos. Como prueba de memoria se utiliz\u00f3 la evitaci\u00f3n inhibitoria de tipo \u00abstep-through\u00bb. Los animales de diferentes experimentos fueron tratados con diferentes dosis de maprotilina, administrada de manera aguda o cr\u00f3nica, bien antes o despu\u00e9s de la fase de adquisici\u00f3n. para comprender mejor el efecto del f\u00e1rmaco sobre la evitaci\u00f3n inhibitoria se estudi\u00f3 tambi\u00e9n su efecto sobre procesos que pueden influir en dicha tarea como son la actividad, la ansiedad y la analgesia. Igualmente se estudi\u00f3 el fen\u00f3meno conocido como aprendizaje dependiente del estado.  los resultados reflejaron que la administraci\u00f3n aguda de maprotilina (5,20 \u00f3 25 mg\/kg) produjo un deterioro de la adquisici\u00f3n y\/o consolidaci\u00f3n de la evitaci\u00f3n inhibitoria, pero se encontraron variaciones en funci\u00f3n de la cepa y del g\u00e9nero de los animales empleados, siendo algo m\u00e1s fuerte el efecto observado en los ratones of 1 que en los cd 1 y en las hembras que en los machos. La administraci\u00f3n cr\u00f3nica, durante veinti\u00fan d\u00edas, de 5 y 20 mg\/kg de maprotilina deterior\u00f3 la memoria en animales machos of 1, y la dosis de 25 mg\/kg no afect\u00f3 la memoria de animales macho o hembras cd-1.  la administraci\u00f3n aguda de 20 y 25 mg\/kg de maprotilina produjo una reducci\u00f3n de la actividad locomotora, as\u00ed como un efecto analg\u00e9sico en animales ma<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos de la maprotilina sobre la evitaci\u00f3n inhibitoria en ratones machos y hembras<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos de la maprotilina sobre la evitaci\u00f3n inhibitoria en ratones machos y hembras <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Martos Mula Ana Josefa <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 12\/07\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Concepci\u00f3n Vinader Caerols<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: vicente Sim\u00f3n p\u00e9rez <\/li>\n<li>Jorge  Luis Arias perez (vocal)<\/li>\n<li>salvador Algarabel gonz\u00e1lez (vocal)<\/li>\n<li>cosme Salas Garc\u00eda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Martos Mula Ana Josefa Los antidepresivos constituyen un grupo de psicof\u00e1rmacos que son consumidos a gran escala [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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