{"id":18453,"date":"2018-03-09T09:06:59","date_gmt":"2018-03-09T09:06:59","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/polimorfismo-genetico-del-receptor-cd-14-y-periodontitis-agresiva-generalizada\/"},"modified":"2018-03-09T09:06:59","modified_gmt":"2018-03-09T09:06:59","slug":"polimorfismo-genetico-del-receptor-cd-14-y-periodontitis-agresiva-generalizada","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/polimorfismo-genetico-del-receptor-cd-14-y-periodontitis-agresiva-generalizada\/","title":{"rendered":"Polimorfismo gen\u00e9tico del receptor cd-14 y periodontitis agresiva generalizada"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Juan  Manuel Morillo Vel\u00e1zquez <\/strong><\/h2>\n<p>La periodontitis agresiva generalizada (pag) es una patolog\u00eda caracterizada por la destrucci\u00f3n de tejidos periodontales, con un curso progresivo y comienzo antes de los 30 a\u00f1os. Existe un componente gen\u00e9tico en gran parte de los afectados. Se ha hallado una respuesta an\u00f3mala ante las bacterias iniciadoras del cuadro. El receptor cd14 es una mol\u00e9cula que capta el lipopolisac\u00e1rido de las bacterias gramnegativas y activa diversas v\u00edas proinflamatorias. se ha implicado en la respuesta frente a porphyromonas gingivalis. Existen dos polimorfismos en su promotor, relacionados con diversas patolog\u00edas.  los objetivos fueron establecer la relaci\u00f3n entre los polimorfimos en las posiciones -260 y -159 del gen cd14; determinar si pueden ser un factor de susceptibilidad para sufrir pag y as\u00ed como un factor de severidad en sujetos afectados de pag. Se registr\u00f3 la situaci\u00f3n cl\u00ednica y se tomaron muestras de fluido gingival de 35 casos y 25 controles, se analizaron mediante pcr y digesti\u00f3n con haell y avall para distinguir los alelos en -260 y -159. Se compar\u00f3 la distribuci\u00f3n de alelos y genotipos en ambos grupos y se aplic\u00f3 el programa estad\u00edstico clump. En el grupo de casos, se relacion\u00f3 la profundidad de sondaje con la constituci\u00f3n gen\u00e9tica mediante el test de la u de mann-whitney.  se ha podido demostrar un error en la nomenclatura de dichos polimorfismos, de tal forma que solo existe el localizado en -159. El alelo c y el genotipo cc se encuentran en mayor proporci\u00f3n en los casos, aunque no de forma estad\u00edsticamente significativa. Existe una tendencia casi significativa a mayor porcentaje de bolsas, principalmente de 4-6 mm, en los portadores de los genotipos cc y ct en relaci\u00f3n con tt, por lo que podr\u00eda tenerse en consideraci\u00f3n como potencial marcador de extensi\u00f3n de la enfermedad.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Polimorfismo gen\u00e9tico del receptor cd-14 y periodontitis agresiva generalizada<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Polimorfismo gen\u00e9tico del receptor cd-14 y periodontitis agresiva generalizada <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Juan  Manuel Morillo Vel\u00e1zquez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 15\/07\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juliana Fari\u00f1a Gonz\u00e1lez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio Bacones mart\u00ednez <\/li>\n<li> Castrillo diez Jos\u00e9 Luis (vocal)<\/li>\n<li>Jos\u00e9 Fernandez piqueras (vocal)<\/li>\n<li>augusto Silva gonzalez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Juan Manuel Morillo Vel\u00e1zquez La periodontitis agresiva generalizada (pag) es una patolog\u00eda caracterizada por la destrucci\u00f3n de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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