{"id":18509,"date":"2018-03-09T09:07:04","date_gmt":"2018-03-09T09:07:04","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/distribucion-de-las-alcohol-deshidrogenasas-adh1-y-adh4-en-tejidos-de-rata-relevancia-en-el-metabolismo-de-etanol-y-retinoides\/"},"modified":"2018-03-09T09:07:04","modified_gmt":"2018-03-09T09:07:04","slug":"distribucion-de-las-alcohol-deshidrogenasas-adh1-y-adh4-en-tejidos-de-rata-relevancia-en-el-metabolismo-de-etanol-y-retinoides","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/distribucion-de-las-alcohol-deshidrogenasas-adh1-y-adh4-en-tejidos-de-rata-relevancia-en-el-metabolismo-de-etanol-y-retinoides\/","title":{"rendered":"Distribuci\u00f3n de las alcohol deshidrogenasas adh1 y adh4 en tejidos de rata. relevancia en el metabolismo de etanol y retinoides"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Mart\u00ednez Rodr\u00edguez Susana Eva <\/strong><\/h2>\n<p>En la presente tesis, se ha abordado el estudio detallado de la localizaci\u00f3n de distintas formas de alcohol deshidrogenasa (adh) en tejidos de rata y, en particular, en el sistema vascular, tracto gastrointestinal, sistema nervioso central y tejidos oculares. Se han estudiado esencialmente adh1 y adh4, que son los enzimas m\u00e1s relevantes en la oxidaci\u00f3n de etanol a acetaldeh\u00eddo, y en la oxidaci\u00f3n de retinoll al retinal en la v\u00eda de s\u00edntesis del \u00e1cido retinoico.  adh4 y adh1b1 se detectaron como las formas principales en los vasos sangu\u00edneos de rata y humano, respectivamente. Tanto adh1 como adh4, se han detectado a lo largo de todo el tracto gastrointestinal, principalmente en la mucosa, variando su cantidad relativa y su ubicaci\u00f3n celular en funci\u00f3n del \u00e1rea estudiada. Adh4 es m\u00e1s abundante en las partes m\u00e1s externas del tracto (boca, es\u00f3fago, colon y recto), mientras que adh1 es la forma mayoritaria en el intestino. En el cerebro, mediante hibridaci\u00f3n in situ, ambas formas de adh se han localizado en el cerebelo, formaci\u00f3n hipocampal, \u00e1reas muy concretas de la corteza cerebral, y en el sistema ventricular y vascular asociados al snc. En los tejidos oculares, tan s\u00f3lo adh4, el mrna y la prote\u00edna, se ha localizado en la coroides, cuerpo ciliar, nervio \u00f3ptico y en capas concretas de la c\u00f3rnea y retina.  finalmente, se ha comparado el patr\u00f3n de expresi\u00f3n adh en tejido hep\u00e1tico con el de una l\u00ednea celular de hepatocarcinoma. La l\u00ednea de hepatocarcinoma de rata hy4iiec3 mostr\u00f3 la expresi\u00f3n de adh1 y adh3, presentes en h\u00edgado normal, y, adem\u00e1s, adh4, ausente en h\u00edgado. Se investig\u00f3 el efecto del \u00e1ctido retinoico sobre la expresi\u00f3n de cada una de las tres formas de adh. se ha observado un aumento de los niveles de mrna de adh1 y un descenso de los de adh4, mientras que los niveles de mrna de adh3 se mantuvieron constantes.  la distribuci\u00f3n de adh1 y adh4, junto con sus propiedades cin\u00e9ticas y su regulaci\u00f3<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Distribuci\u00f3n de las alcohol deshidrogenasas adh1 y adh4 en tejidos de rata. relevancia en el metabolismo de etanol y retinoides<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Distribuci\u00f3n de las alcohol deshidrogenasas adh1 y adh4 en tejidos de rata. relevancia en el metabolismo de etanol y retinoides <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Mart\u00ednez Rodr\u00edguez Susana Eva <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/07\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Xavier Par\u00e9s Casasampera<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: victoria Nogu\u00e9s Mar\u00eda <\/li>\n<li>joan Caballer\u00eda (vocal)<\/li>\n<li>consuelo Guerri (vocal)<\/li>\n<li>Juan Hidalgo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mart\u00ednez Rodr\u00edguez Susana Eva En la presente tesis, se ha abordado el estudio detallado de la localizaci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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