{"id":18520,"date":"2018-03-09T09:07:05","date_gmt":"2018-03-09T09:07:05","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/apoptosis-inducida-en-la-la%c2%adnea-celular-prostatica-lncap-valoracion-del-posible-efecto-inductor-de-resistencia-tras-la-adicion-de-neuropeptidos\/"},"modified":"2018-03-09T09:07:05","modified_gmt":"2018-03-09T09:07:05","slug":"apoptosis-inducida-en-la-la%c2%adnea-celular-prostatica-lncap-valoracion-del-posible-efecto-inductor-de-resistencia-tras-la-adicion-de-neuropeptidos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/apoptosis-inducida-en-la-la%c2%adnea-celular-prostatica-lncap-valoracion-del-posible-efecto-inductor-de-resistencia-tras-la-adicion-de-neuropeptidos\/","title":{"rendered":"Apopt\u00f3sis inducida en la l\u00ednea celular prost\u00e1tica lncap: valoraci\u00f3n del posible efecto inductor de resistencia tras la adici\u00f3n de neurop\u00e9ptidos"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Moreno Santos M. \u00e1ngeles <\/strong><\/h2>\n<p>Introducci\u00f3n  el carcinoma prost\u00e1tico es una enfermedad t\u00edpicamente refractaria al tratamiento hormonal. En estudios recientes se ha visto que, adem\u00e1s de los andr\u00f3genos, hay otras sustancias implicadas en el normal desarrollo y funcionamiento de la gl\u00e1ndula prost\u00e1tica, tales son los factores de crecimiento pept\u00eddicos y los neurop\u00e9ptidos. A este respecto, se ha visto que la diferenciaci\u00f3n neuroendocrina se asocia con un peor pron\u00f3stico y estadio tumoral m\u00e1s avanzado.  el cultivo de c\u00e9lulas tumorales es una herramienta muy \u00fatil a la hora de estudiar la biolog\u00eda del c\u00e1ncer, ya que nos permite recrear distintas condiciones o a\u00f1adir al medio distintas sustancias y ver c\u00f3mo responden a ellas las c\u00e9lulas cancerosas. En la presente tesis doctoral hemos empleado la l\u00ednea celular prost\u00e1tica andr\u00f3geno-sensible lncap para intentar aclarar el papel que desempe\u00f1an los neurop\u00e9ptidos en la biolog\u00eda del carcinoma prost\u00e1tico.  objetivos  1,- obtenci\u00f3n de patrones cualitativos y cuantitativos en c\u00e9lulas prost\u00e1ticas neopl\u00e1sicas sometidas a tratamiento inductor de apoptosis.  2,- comprobar si los neurop\u00e9ptidos son capaces de inducir resistencia a la apoptosis, a trav\u00e9s de estudios morfol\u00f3gicos y cuantitativos.  3,- valorar la aparici\u00f3n de subpoblaciones tumorales en distintos estadios apopt\u00f3ticos, en los distintos grupos de tratamiento, mediante criterios morfol\u00f3gicos y cuantitativos.  4,- cuantificar la relaci\u00f3n existente entre los productos de secreci\u00f3n de las c\u00e9lulas neuroendocrinas y el establecimiento y evoluci\u00f3n del proceso de apoptosis.  material y m\u00e9todo  se establecieron distintos grupos de tratamiento en la l\u00ednea celular lncap (control, etop\u00f3sido, bombesina y etop\u00f3sido mas bombesina). Al final de cada experimento los grupos se procesaron para tinci\u00f3n hematoxilina-eosina, tinci\u00f3n dapi y cuantificaci\u00f3n de las concentraciones de calcio intracelular (mediante el uso de fluo-3 y fluoroskan ascent(<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Apopt\u00f3sis inducida en la l\u00ednea celular prost\u00e1tica lncap: valoraci\u00f3n del posible efecto inductor de resistencia tras la adici\u00f3n de neurop\u00e9ptidos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Apopt\u00f3sis inducida en la l\u00ednea celular prost\u00e1tica lncap: valoraci\u00f3n del posible efecto inductor de resistencia tras la adici\u00f3n de neurop\u00e9ptidos <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Moreno Santos M. \u00e1ngeles <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00e1diz<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/07\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mercedes Salido Perucaula<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: guillermo S\u00e1nchez salgado <\/li>\n<li>pascual vicente Crespo ferrer (vocal)<\/li>\n<li>Jos\u00e9 Vilches troya (vocal)<\/li>\n<li>Antonio Lopez  mu\u00f1oz (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Moreno Santos M. \u00e1ngeles Introducci\u00f3n el carcinoma prost\u00e1tico es una enfermedad t\u00edpicamente refractaria al tratamiento hormonal. En [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[849,1506,8901,35,9,848,1989,52,156],"tags":[1713,3157,1670,20679,57398,53141],"class_list":["post-18520","post","type-post","status-publish","format-standard","hentry","category-biologia-celular","category-cadiz","category-carcinogenesis","category-ciencias-de-la-vida","category-ciencias-medicas","category-citologia","category-cultivo-de-tejidos","category-histopatologia","category-patologia","tag-antonio-lopez-munoz","tag-guillermo-sanchez-salgado","tag-jose-vilches-troya","tag-mercedes-salido-perucaula","tag-moreno-santos-m-angeles","tag-pascual-vicente-crespo-ferrer"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/18520","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=18520"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/18520\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=18520"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=18520"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=18520"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}