{"id":18523,"date":"2018-03-09T09:07:05","date_gmt":"2018-03-09T09:07:05","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/funcion-carda%c2%adaca-sistolica-y-diastolica-en-la-spesis-severa-y-polimorfismo-genomico-en-el-factor-de-necrosis-tumoral\/"},"modified":"2018-03-09T09:07:05","modified_gmt":"2018-03-09T09:07:05","slug":"funcion-carda%c2%adaca-sistolica-y-diastolica-en-la-spesis-severa-y-polimorfismo-genomico-en-el-factor-de-necrosis-tumoral","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/funcion-carda%c2%adaca-sistolica-y-diastolica-en-la-spesis-severa-y-polimorfismo-genomico-en-el-factor-de-necrosis-tumoral\/","title":{"rendered":"Funci\u00f3n card\u00edaca sist\u00f3lica y diast\u00f3lica en la spesis severa y polimorfismo gen\u00f3mico en el factor de necrosis tumoral"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Santos Bouza Antonio  Amadeo <\/strong><\/h2>\n<p>Introducci\u00f3n  la sepsis grave se acompa\u00f1a de disfunci\u00f3n sist\u00f3lica y diast\u00f3lica cl\u00ednica y experimental. La adaptaci\u00f3n a la precarga por dilataci\u00f3n ventricular izquierda y depresi\u00f3n aguda de la funci\u00f3n sist\u00f3lica, m\u00e1s marcadas en los supervivientes, es un concepto aceptado en el shock s\u00e9ptico. Habitualmente los \u00edndices empleados son invasivos y dependientes de la carga. Sin embargo, la verdadera postcarga del ventr\u00edculo izquierdo (tensi\u00f3n telesist\u00f3lica) y sus \u00edndices eyectivos pueden ser calculados por ecograf\u00eda transtor\u00e1cica (ett). Adem\u00e1s la relaci\u00f3n tensi\u00f3n-acotamiento valora la funci\u00f3n contr\u00e1ctil sin dependencia de la carga, pero no se ha empleado en pacientes cr\u00edticos. tambi\u00e9n hay alteraciones diast\u00f3licas en la sepsis insuficientemente corroboradas en cl\u00ednica.  diferencias gen\u00e9ticas como el sexo o los polimorfismos del gen del tumor necrosis factor (tnf) se ha considerado del m\u00e1ximo inter\u00e9s en la respuesta infalmatoria a la sepsis. Se ha atribuido un pero pron\u00f3stico a los pacientes s\u00e9pticos con alelo tnfb2, especialmente homocigotos tnf b2\/b2 del g\u00e9nero masculino. Tambi\u00e9n se ha demostrado que el tnf induce disfunci\u00f3n mioc\u00e1rdica, y hay indicios de que un polimorfismo en el gen de tnf puede determinar susceptibilidad a la miocardiopat\u00eda dilatada. En consecuencia, la aparici\u00f3n de disfunci\u00f3n mioc\u00e1rdica o su evoluci\u00f3n a la sepsis podr\u00edan ser determinadas por un polimorifismo gen\u00e9tico del tnf.  objetivos  1\u00c2\u00ba,- medici\u00f3n no invasiva en fase aguda de la sepsis y seguimiento evolutivo mediante ett de postcarga, funci\u00f3n contr\u00e1ctil (independiente de la carga) y funci\u00f3n diast\u00f3lica.  2\u00c2\u00ba,- relacionar del genotipo tnf con la disfunci\u00f3n cardiaca en la sepsis.  m\u00e9todo  consentimiento informado, ett, frecuencia card\u00edaca y tensi\u00f3n arterial en fase aguda de la sepsis para c\u00e1lculos de funci\u00f3n cardiaca. Genotipado: extracci\u00f3n adn leucocitario, amplificaci\u00f3n pcr 1\u00c2\u00ba intr\u00f3n tnf beta, digesti\u00f3n<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Funci\u00f3n card\u00edaca sist\u00f3lica y diast\u00f3lica en la spesis severa y polimorfismo gen\u00f3mico en el factor de necrosis tumoral<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Funci\u00f3n card\u00edaca sist\u00f3lica y diast\u00f3lica en la spesis severa y polimorfismo gen\u00f3mico en el factor de necrosis tumoral <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Santos Bouza Antonio  Amadeo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/07\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Angel Mar\u00eda Carracedo Alvarez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 ram\u00f3n Gonz\u00e1lez Juan atey <\/li>\n<li> Rivera otero Jos\u00e9 Miguel (vocal)<\/li>\n<li>Fernando Dominguez puente (vocal)<\/li>\n<li>Francisco Taboada costa (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Santos Bouza Antonio Amadeo Introducci\u00f3n la sepsis grave se acompa\u00f1a de disfunci\u00f3n sist\u00f3lica y diast\u00f3lica cl\u00ednica y [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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