{"id":18528,"date":"2018-03-09T09:07:05","date_gmt":"2018-03-09T09:07:05","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-funcional-de-diferentes-va%c2%adas-de-senalizacion-intracelular-sobre-la-exocitosis-regulacion-e-implicaciones-farmacologicas\/"},"modified":"2018-03-09T09:07:05","modified_gmt":"2018-03-09T09:07:05","slug":"estudio-funcional-de-diferentes-va%c2%adas-de-senalizacion-intracelular-sobre-la-exocitosis-regulacion-e-implicaciones-farmacologicas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-funcional-de-diferentes-va%c2%adas-de-senalizacion-intracelular-sobre-la-exocitosis-regulacion-e-implicaciones-farmacologicas\/","title":{"rendered":"Estudio funcional de diferentes v\u00edas de se\u00f1alizaci\u00f3n intracelular sobre la exocitosis. regulaci\u00f3n e implicaciones farmacol\u00f3gicas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jos\u00e9 David Machado Ponce <\/strong><\/h2>\n<p>La exocitosis es un proceso celular universal y es la manera m\u00e1s com\u00fan para secretar mensajeros qu\u00edmicos y renovar los componentes del plasmalema. consiste en la fusi\u00f3n de una ves\u00edcula citoplasm\u00e1tica con la membrana plasm\u00e1tica, de tal manera que las sustancias almacenadas en el interior de la ves\u00edcula se liberan de forma unidireccional al medio extracelular. Este procedimiento complejo es el empleado para la liberaci\u00f3n cu\u00e1ntica de la mayor\u00eda de los neurotransmisores.  los resultados de esta memoria de tesis muestran c\u00f3mo f\u00e1rmacos, a diferentes concentraciones, son capaces de establecer diferencias en los procesos que controlan la cin\u00e9tica de exocitosis, el contenido cu\u00e1ntico y la frecuencia de liberaci\u00f3n.  varios experimentos, llevados a cabo empleando t\u00e9cnicas amperom\u00e9tricas han mostrado que ves\u00edculas secretoras, aun cuando tienen la misma cantidad de neurotransmisor, pueden liberar su contenido con diferente cin\u00e9tica.  en esta memoria se describen diferentes aproximaciones farmacol\u00f3gicas y de regulaci\u00f3n por segundos mensajeros que sugieren que el contenido ca en las ves\u00edculas maduras puede modificarse (aumentar o disminuir), siendo \u00e9ste el motivo, en esas condiciones experimentales, por el cual aumenta o disminuye la secreci\u00f3n. Todo esto sin que suponga un aumento o disminuci\u00f3n de la frecuencia de exocitosis.  la cantidad total de ca secretadas y la cin\u00e9tica de liberaci\u00f3n de cada una de las ves\u00edculas por exocitosis pueden verse afectadas de forma diferencial por segundos mensajeros y f\u00e1rmacos. Este planteamiento es el origen de esta discusi\u00f3n y es el que genera nuevas hip\u00f3tesis sobre la regulaci\u00f3n fina y la eficacia de la transmisi\u00f3n sin\u00e1ptica.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio funcional de diferentes v\u00edas de se\u00f1alizaci\u00f3n intracelular sobre la exocitosis. regulaci\u00f3n e implicaciones farmacol\u00f3gicas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio funcional de diferentes v\u00edas de se\u00f1alizaci\u00f3n intracelular sobre la exocitosis. regulaci\u00f3n e implicaciones farmacol\u00f3gicas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jos\u00e9 David Machado Ponce <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 La laguna<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/07\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ricardo Borges Jurado<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio Garc\u00eda Garc\u00eda <\/li>\n<li>Rafael Alonso sol\u00eds (vocal)<\/li>\n<li>Jos\u00e9 nicolas Boada ju\u00e1rez (vocal)<\/li>\n<li>Francisco Sala merch\u00e1n (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jos\u00e9 David Machado Ponce La exocitosis es un proceso celular universal y es la manera m\u00e1s com\u00fan [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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