{"id":18529,"date":"2018-03-09T09:07:05","date_gmt":"2018-03-09T09:07:05","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/lesiones-cutaneo-mucosas-secundarias-al-tratamiento-quimioterapico-en-el-paciente-oncologico-estudio-cla%c2%adnico-patologico\/"},"modified":"2018-03-09T09:07:05","modified_gmt":"2018-03-09T09:07:05","slug":"lesiones-cutaneo-mucosas-secundarias-al-tratamiento-quimioterapico-en-el-paciente-oncologico-estudio-cla%c2%adnico-patologico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/lesiones-cutaneo-mucosas-secundarias-al-tratamiento-quimioterapico-en-el-paciente-oncologico-estudio-cla%c2%adnico-patologico\/","title":{"rendered":"Lesiones cut\u00e1neo-mucosas secundarias al tratamiento quimioter\u00e1pico en el paciente oncol\u00f3gico. estudio cl\u00ednico-patol\u00f3gico"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Onofre Sanmartin Jimenez <\/strong><\/h2>\n<p>El mayor reto diagn\u00f3stico en dermatolog\u00eda en la valoraci\u00f3n de las lesiones cut\u00e1neas del paciente oncol\u00f3gico los constituyen las lesiones inducidas por el tratamiento citost\u00e1tico. Esta tesis doctoral revisa las lesiones cut\u00e1neas acaecidas en un grupo de 2186 pacientes sometidos a quimioterapia en un periodo de tres a\u00f1os. El 23,14% de los pacientes desarroll\u00f3 lesiones cut\u00e1neas, de estas el 52,17% fueron debidas a los agentes citost\u00e1licos. las manifestaciones cl\u00ednicas que sugirieron un origen relacionado con la medicaci\u00f3n antineopl\u00e1sica fueron el eritema palmo-plantar, las hiperpigmentaciones, las placas inflamatorias en pliegues y zonas de oclusi\u00f3n y las alteraciones ungueales. Las manifestaciones histol\u00f3gicas que sugirieron que las lesiones fueron inducidas por la quimioterapia fueron la dermatitis de interfase escasamente celular, la degeneraci\u00f3n hidr\u00f3pica basal, la atrofia epid\u00e9rmica, la necrosis de queratinocitos, las atipias celulares en  queratinocitos y en c\u00e9lulas del infiltrado inflamatorio. La tesis doctoral efect\u00faa una clasificaci\u00f3n de las lesiones cut\u00e1neas en patroclinico-patol\u00f3gicos, diferenciando entre entidades originadas por mecanismos de citotoxicidad y originadas por mecanismos de hipersensibilidad. A su vez, las lesiones debidas a citotoxicidad puede clasificarse dependiendo del \u00f3rgano diana en lesiones por citotoxicidad epid\u00e9rmica, ecrina, folicular, ungueal, sobre tejido celular subcut\u00e1neo e hiperpigmentaciones.  hemos encontrado varias entidades clinico-patol\u00f3gicas inducidas por quinioterapia que, por su cl\u00ednica homog\u00e9nea, sus hallazgos histopatol\u00f3gicos particulares y su asociaci\u00f3n a f\u00e1rmacos concretos, permiten identificarlos como cuadros propios. Se trata de la foliculits el cuero cabelludo y la nel en zonas de oclusi\u00f3n.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Lesiones cut\u00e1neo-mucosas secundarias al tratamiento quimioter\u00e1pico en el paciente oncol\u00f3gico. estudio cl\u00ednico-patol\u00f3gico<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Lesiones cut\u00e1neo-mucosas secundarias al tratamiento quimioter\u00e1pico en el paciente oncol\u00f3gico. estudio cl\u00ednico-patol\u00f3gico <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Onofre Sanmartin Jimenez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/07\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Adolfo Aliaga Boniche<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: evaristo S\u00e1nchez yus <\/li>\n<li>vicente Alberola candel (vocal)<\/li>\n<li>Antonio Llombart bosch (vocal)<\/li>\n<li>Carlos Ferr\u00e1ndiz foraster (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Onofre Sanmartin Jimenez El mayor reto diagn\u00f3stico en dermatolog\u00eda en la valoraci\u00f3n de las lesiones cut\u00e1neas del [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[155,9,189,484,347],"tags":[11783,12285,158,15586,57421,11727],"class_list":["post-18529","post","type-post","status-publish","format-standard","hentry","category-ciencias-clinicas","category-ciencias-medicas","category-farmacodinamia","category-mecanismos-de-accion-de-la-quimioterapia","category-oncologia-clinica","tag-adolfo-aliaga-boniche","tag-antonio-llombart-bosch","tag-carlos-ferrandiz-foraster","tag-evaristo-sanchez-yus","tag-onofre-sanmartin-jimenez","tag-vicente-alberola-candel"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/18529","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=18529"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/18529\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=18529"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=18529"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=18529"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}