{"id":18530,"date":"2018-03-09T09:07:06","date_gmt":"2018-03-09T09:07:06","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/modelado-farmacocinetico-de-ciclosporina-en-pacientes-con-trasplante-renal\/"},"modified":"2018-03-09T09:07:06","modified_gmt":"2018-03-09T09:07:06","slug":"modelado-farmacocinetico-de-ciclosporina-en-pacientes-con-trasplante-renal","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/modelado-farmacocinetico-de-ciclosporina-en-pacientes-con-trasplante-renal\/","title":{"rendered":"Modelado farmacocin\u00e9tico de ciclosporina en pacientes con trasplante renal"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Bego\u00f1a Porta Oltra <\/strong><\/h2>\n<p>La estrecha relaci\u00f3n establecida entre la concentraci\u00f3n en sangre de ciclosporina y su respuesta terap\u00e9utica y t\u00f3xica, as\u00ed como la alta variabilidad \u00ednter e intraindividual encontrada en los procesos cin\u00e9ticos y din\u00e1micos, ha determinado la necesidad de la monitorizaci\u00f3n de las concentraciones de ciclosporina en sangre total, dentro de la pr\u00e1ctica cl\u00ednica. Su finalidad es disponer de informaci\u00f3n suficiente para alcanzar la individualizaci\u00f3n posol\u00f3gica, mediante la metodolog\u00eda bayesiana.  el elevado n\u00famero de muestras de sangre necesarias para llevar a cabo las estrategias de individualizaci\u00f3n posol\u00f3gica basadas en la medida de la exposici\u00f3n sist\u00e9mica, ha dificultado su aplicaci\u00f3n por lo que la monitorizaci\u00f3n de ciclosporina ha permanecido anclada en la determinaci\u00f3n de la concentraci\u00f3n sangu\u00ednea valle.  el escenario descrito es b\u00e1sicamente el punto de partida de la hip\u00f3tesis planteada en la presente memoria de tesis doctoral cuyos objetivos han sido:  i. Objetivo principal  caracterizar el comportamietno farmacocin\u00e9tico de ciclosporina oral en pacientes con trasplante renal, a partir de la concentraci\u00f3n sangu\u00ednea valle, en funci\u00f3n del tiempo post-trasplante.  ii. Objetivo secundarios  1,- identificar y evaluar los factores que influyen en la aceptaci\u00f3n del informe farmacoterap\u00e9utico de monitorizaci\u00f3n de las concentraciones sangu\u00edneas valle de ciclosporina.  2,- identificar y evaluar la influencia de diferentes covariables sobre la tendencia central de los par\u00e1metros farmacocin\u00e9ticos de ciclosporina y sus respectivas variabilidades.  3,- desarrollar y validar un m\u00e9todo bayesiano para el ajuste individualizado de dosis basado en el modelo farmacoestad\u00edstico desarrollado.  el dise\u00f1o del estudio farmacocin\u00e9tico exigi\u00f3 el desarrollo y la validaci\u00f3n de la t\u00e9cnica anal\u00edtica y el establecimiento de su modelo de varianza, a su vez, se ha llevado a cabo un an\u00e1lisis con el objetivo de valorar<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Modelado farmacocin\u00e9tico de ciclosporina en pacientes con trasplante renal<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Modelado farmacocin\u00e9tico de ciclosporina en pacientes con trasplante renal <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Bego\u00f1a Porta Oltra <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/07\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> P\u00e9rez Riuxo Juan  Jos\u00e9<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jose Domenech berrozpe <\/li>\n<li>itreme Molina mart\u00ednez (vocal)<\/li>\n<li>azucena Aldaz pastor (vocal)<\/li>\n<li>Emilio Soria olivas (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Bego\u00f1a Porta Oltra La estrecha relaci\u00f3n establecida entre la concentraci\u00f3n en sangre de ciclosporina y su respuesta [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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