{"id":18564,"date":"2018-03-09T09:07:09","date_gmt":"2018-03-09T09:07:09","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-glicoproteina-fusogenica-f-del-paramyxovirua-sv5-como-nueva-herramienta-para-eliminar-celulas-tumorales\/"},"modified":"2018-03-09T09:07:09","modified_gmt":"2018-03-09T09:07:09","slug":"estudio-de-la-glicoproteina-fusogenica-f-del-paramyxovirua-sv5-como-nueva-herramienta-para-eliminar-celulas-tumorales","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-de-la-glicoproteina-fusogenica-f-del-paramyxovirua-sv5-como-nueva-herramienta-para-eliminar-celulas-tumorales\/","title":{"rendered":"Estudio de la glicoproteina fusogenica (f) del paramyxovirua sv5 como nueva herramienta para eliminar celulas tumorales"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  G\u00f3mez Trevi\u00f1o Jes\u00fas Alberto <\/strong><\/h2>\n<p>La glicoprote\u00edna fosog\u00e9nica (f) del paramyxovirus sv5 media la entrada del mismo en la c\u00e9lula hu\u00e9sped y provoca la fusi\u00f3n de \u00e9sta con las c\u00e9lulas de alrededor. Este proceso desencadena la aparici\u00f3n de masas de c\u00e9lulas fusionadas, denominadas sincitios, y que conduce finalmente a la muerte celular a causa de trastornos metab\u00f3licos y lisis de la membrana citoplasm\u00e1tica.  se construyeron vectores adenovirales no replicativos para sobre-expresar la glicoprote\u00edna f de sv5 en distintas l\u00edneas celulares de origen tumoral en cultivo. Los resultados de los ensayos realizados muestran una alta citotoxicidad por parte de la glicoprote\u00edna f y que es comparable a la del sistema de terapia suicida timidina quinasa\/ganciclovir. La inducci\u00f3n a la formaci\u00f3n de sincitios se observa a las 48 horas post-infecci\u00f3n, los cuales pierden viabilidad progresivamente. Se demostr\u00f3 tambi\u00e9n que la expresi\u00f3n de esta glicoprote\u00edna posee un potente efecto bystander hasta en raz\u00f3n de 1:100 sobre c\u00e9lulas no transducidas. Los estudios de microscop\u00eda confocal y electr\u00f3nica muestran cambios morfol\u00f3gicos en las c\u00e9lulas transducidas que incluyen, vascuolizaci\u00f3n de mitocondrias, rarefacci\u00f3n del citoplasma, adem\u00e1s de importanes da\u00f1os en la membrana citoplasm\u00e1tica mientras se preserva la estructura nuclear. Estos da\u00f1os en la membrana inducen una mayor difusi\u00f3n de metabolitos t\u00f3xicos al ensayar la expresi\u00f3n de la glicoprote\u00edna f de manera conjunta con sistemas de activaci\u00f3n de pro-drogas como cyp2b1\/ciclofosfamida o timidina quinasa\/ganciclovir.  estos resultados indican que la sobre-expresi\u00f3n de la glicoprote\u00edna f del paramyxovirus sv5 induce la muerte celular por alteraci\u00f3n de la estructura de la membrana celular y la formaci\u00f3n de sincitios no viables, lo cual puede ser utilizado en la eliminaci\u00f3n de c\u00e9lulas tumorales.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la glicoproteina fusogenica (f) del paramyxovirua sv5 como nueva herramienta para eliminar celulas tumorales<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la glicoproteina fusogenica (f) del paramyxovirua sv5 como nueva herramienta para eliminar celulas tumorales <\/li>\n<li><strong>Autor:<\/strong>\u00a0  G\u00f3mez Trevi\u00f1o Jes\u00fas Alberto <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/07\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Elena Mercade Gil<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jes\u00fas Guinea s\u00e1nchez <\/li>\n<li>joaqu\u00edn Arribas l\u00f3pez (vocal)<\/li>\n<li>ignasi Calic\u00f3 bosch (vocal)<\/li>\n<li>cristina Fillat fonts (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de G\u00f3mez Trevi\u00f1o Jes\u00fas Alberto La glicoprote\u00edna fosog\u00e9nica (f) del paramyxovirus sv5 media la entrada del mismo en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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