{"id":18580,"date":"2018-03-09T09:07:10","date_gmt":"2018-03-09T09:07:10","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/replicacion-y-recombinacion-en-ora%c2%adgenes-de-replicacion-en-schizosaccharomyces-pombe\/"},"modified":"2018-03-09T09:07:10","modified_gmt":"2018-03-09T09:07:10","slug":"replicacion-y-recombinacion-en-ora%c2%adgenes-de-replicacion-en-schizosaccharomyces-pombe","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/replicacion-y-recombinacion-en-ora%c2%adgenes-de-replicacion-en-schizosaccharomyces-pombe\/","title":{"rendered":"Replicaci\u00f3n y recombinaci\u00f3n en or\u00edgenes de replicaci\u00f3n en schizosaccharomyces pombe"},"content":{"rendered":"<h2>Tesis doctoral de <strong> M\u00f3nica Segurado Carrascal <\/strong><\/h2>\n<p>La recombinaci\u00f3n gen\u00e9tica juega un importante papel en el reparaci\u00f3n de da\u00f1os en el dna incudios durante la replicaci\u00f3n. Se conocen diversas mutaciones que afectan a prote\u00ednas que intervienen en la replicaci\u00f3n como dna polimerasas, helicasas o ligasas que provocan un aumento de la recombinaci\u00f3n mit\u00f3tica. En sistemas procariotas se ha demostrado que la recombinaci\u00f3n asegura que la replicaci\u00f3n sea completa reparando horquillas colapsadas o incluso es necesaria para iniciar la replicaci\u00f3n. En eucariotas estos procesos son menos conocidos, pero se piensa que la recombinaci\u00f3n entre crom\u00e1tidas hermanas es responsable de la reparaci\u00f3n de lesiones producidas durante la replicaci\u00f3n.  por medio de electroforesis bidimensional hemos estudiado la recombinaci\u00f3n mit\u00f3tica en schizosaccharomyces pombe durante la fase de s\u00edntesis del dna. nuestros resultados indican que los intermediarios de recombinaci\u00f3n aparecen \u00fanicamente en regiones que contienen origenes de replicaci\u00f3n. An\u00e1lisis de cultivos sincr\u00f3nicos de varias regiones del genoma que funcionan como or\u00edgenes de replicaci\u00f3n, revelan que la aparici\u00f3n de intermediarios de holliday sigue la misma cin\u00e9tica que la activaci\u00f3n del or\u00edgen.  hemos determinado la frecuencia de integraci\u00f3n en diferentes puntos del genoma, de un pl\u00e1smido linearizado que contiene el gen marcador ura+ y hemos encontrado que la frecuencia de recombinaci\u00f3n hom\u00f3loga est\u00e1 aumetnada de 15 a 20 veces en regiones pr\u00f3ximas a or\u00edgenes de replicaci\u00f3n, por lo que sugerimos que los or\u00edgenes de replicaci\u00f3n en s.Pombe podr\u00edan actuar como hotsports de recombinaci\u00f3n.  adem\u00e1s mutantes afectados en genes de reparaci\u00f3n como rad22+, rhp54+, rhp51+ han mostrado un severo defecto tanto en replicaci\u00f3n como en recombinaci\u00f3n. planteamos la posibilidad de que ambos procesos est\u00e9n relacionados funcionalmente en s.Pombe, pudiendo la recombinaci\u00f3n ser necesaria en zonas de inicio de la replicaci\u00f3n para repara<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Replicaci\u00f3n y recombinaci\u00f3n en or\u00edgenes de replicaci\u00f3n en schizosaccharomyces pombe<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Replicaci\u00f3n y recombinaci\u00f3n en or\u00edgenes de replicaci\u00f3n en schizosaccharomyces pombe <\/li>\n<li><strong>Autor:<\/strong>\u00a0 M\u00f3nica Segurado Carrascal <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/07\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Antequera Marquez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: andr\u00e9s Aguilera l\u00f3pez <\/li>\n<li>sergio Moreno p\u00e9rez (vocal)<\/li>\n<li>Jos\u00e9 Ayte del olmo (vocal)<\/li>\n<li>pablo Hern\u00e1ndez valenzuela (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de M\u00f3nica Segurado Carrascal La recombinaci\u00f3n gen\u00e9tica juega un importante papel en el reparaci\u00f3n de da\u00f1os en el [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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