{"id":18583,"date":"2018-03-09T09:07:10","date_gmt":"2018-03-09T09:07:10","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-morfologica-fenota%c2%adpica-citoqua%c2%admica-y-funcional-de-diferentes-subpoblaciones-de-celulas-dendra%c2%adticas-humanas\/"},"modified":"2018-03-09T09:07:10","modified_gmt":"2018-03-09T09:07:10","slug":"caracterizacion-morfologica-fenota%c2%adpica-citoqua%c2%admica-y-funcional-de-diferentes-subpoblaciones-de-celulas-dendra%c2%adticas-humanas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/caracterizacion-morfologica-fenota%c2%adpica-citoqua%c2%admica-y-funcional-de-diferentes-subpoblaciones-de-celulas-dendra%c2%adticas-humanas\/","title":{"rendered":"Caracterizaci\u00f3n morfol\u00f3gica, fenot\u00edpica, citoqu\u00edmica y funcional de diferentes subpoblaciones de c\u00e9lulas dendr\u00edticas humanas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Clara Bueno Uroz <\/strong><\/h2>\n<p>En relaci\u00f3n con los aspectos metodol\u00f3gicos empleados para la identificaci\u00f3n, recuento y caracterizaci\u00f3n de c\u00e9lulas dendr\u00edticas de sp se requiere el empleo de t\u00e9cnica de inmunofluorescencia directa con combinaciones cu\u00e1druples de anticuerpos monoclonales, siendo la combinaci\u00f3n m\u00e1s adecuada la que incluye cd3, cd56, cd14, cd19-fitc\/cd16-pe\/hla dr-perco\/cd33-apc. Para el estudio de la producci\u00f3n de citocinas la estimulaci\u00f3n \u00f3ptima se consigue con lps (s\u00f3lo o en combinaci\u00f3n con ifngamma), durante 6h., En presencia de brefeldina a. La sustituci\u00f3n de brefeldina a por el inhibidor de tace bb3103 permite identificar de manera precisa y sensible las c\u00e9lulas productoras de tnfalfa.  en sp de individuos normales existen dos subpoblaciones de c\u00e9lulas dendr\u00edticas, las c\u00e9lulas dendr\u00edticas mieloides, ligeramente m\u00e1s abundantes, con caracter\u00edsticas fenot\u00edpicas m\u00e1s maduras, con capacidad de producir citocinas en respuesta al lps y que muestran mayor capacidad fagoc\u00edtica y oxidativa, y las c\u00e9lulas dendr\u00edticas linfoplasmocitoides, menos representadas, y en l\u00edneas generales, con rasgos de mayor inmadurez. Adem\u00e1s en sp se identifica una poblaci\u00f3n celular cd16+\/hla dr+\/cd14-\/+ con caracter\u00edsticas morfol\u00f3gicas, citqu\u00edmicas, fenot\u00edpicas y funcionales diferentes de los monocitos y que pudiera tratarse de una tercera subpoblaci\u00f3n de c\u00e9lulas dendr\u00edticas diferente a las dos anteriores.  la incidencia de leucemias\/linfomas de c\u00e9lulas dendr\u00edticas es &lt;1% del total de lma y lnh, debiendo sospecharse ante la evidencia de c\u00e9lulas neopl\u00e1sicas cd56+\/cd4+ y\/o 7.1+ sin expresi\u00f3n de ant\u00edgenos altamente asociados a l\u00ednea t, b o mieloide.  generalmente la c\u00e9lula neopl\u00e1sica muestras rasgos fenot\u00edpicos compatibles con los de la c\u00e9lula dendr\u00edtica linfoplasmocitoide, aunque nuestros resultados indican que tambi\u00e9n existen leucemias de c\u00e9lulas dendr\u00edticas mieloides, lo que apoyar\u00eda la existencia de diferentes v\u00edas de diferenc<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizaci\u00f3n morfol\u00f3gica, fenot\u00edpica, citoqu\u00edmica y funcional de diferentes subpoblaciones de c\u00e9lulas dendr\u00edticas humanas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizaci\u00f3n morfol\u00f3gica, fenot\u00edpica, citoqu\u00edmica y funcional de diferentes subpoblaciones de c\u00e9lulas dendr\u00edticas humanas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Clara Bueno Uroz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/07\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Alberto Orfao De Matos Correia E Vale<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: agust\u00edn Rios <\/li>\n<li>maurizio Bendandi bendandi (vocal)<\/li>\n<li>rocio \u00e1lvarez (vocal)<\/li>\n<li>Luis Escribano mora (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Clara Bueno Uroz En relaci\u00f3n con los aspectos metodol\u00f3gicos empleados para la identificaci\u00f3n, recuento y caracterizaci\u00f3n de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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