{"id":18641,"date":"2018-03-09T09:07:15","date_gmt":"2018-03-09T09:07:15","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/diseno-y-formulacion-de-comprimidos-de-disgregacion-inmediata-de-aceclofenaco\/"},"modified":"2018-03-09T09:07:15","modified_gmt":"2018-03-09T09:07:15","slug":"diseno-y-formulacion-de-comprimidos-de-disgregacion-inmediata-de-aceclofenaco","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/diseno-y-formulacion-de-comprimidos-de-disgregacion-inmediata-de-aceclofenaco\/","title":{"rendered":"Dise\u00f1o y formulaci\u00f3n de comprimidos de disgregaci\u00f3n inmediata de aceclofenaco."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Cristina Guerrero Ar\u00e9valo <\/strong><\/h2>\n<p>El objetivo de la presente tesis doctoral ha sido dirigido hacia la obtenci\u00f3n de una nueva formulaci\u00f3n para comprimidos, que conteniendo aceclofenaco como principio activo y como superdisgregante una carboximetilcelulosa s\u00f3dica reticulada, ac-di-sol, que fuera capaz de dar lugar a una disgregaci\u00f3n inmediata en la cavidad oral, con el fin de facilitar su administraci\u00f3n, fundamentalmente en personas de la tercera edad y ni\u00f1os.  la tesis doctoral abarca desde la caracterizaci\u00f3n, tanto de los componentes as\u00ed como de las distintas formulaciones en estudio, la elaboraci\u00f3n de los comprimidos y determinaci\u00f3n y an\u00e1lisis de los par\u00e1metros de compresi\u00f3n, hasta la caracterizaci\u00f3n de los comprimidos y determinaci\u00f3n y an\u00e1lisis de los par\u00e1metros de compresi\u00f3n, hasta la caracterizaci\u00f3n de los comprimidos obtenidos tras ser sometidos a una serie de ensayos, entre los que destacan el coeficiente de variaci\u00f3n de peso, la resistencia a la rotura, el ensayo de disgregaci\u00f3n \u00abin vitro\u00bb e \u00abin vivo\u00bb, aunque este \u00faltimo tan s\u00f3lo es orientativo, y los ensayos de porosimetr\u00eda de mercurio y de disoluci\u00f3n \u00abin vitro\u00bb a ph 5.5 y ph 6.8.  los resultados muestran que, en principio, las formulaciones estudiadas permiten una obtenci\u00f3n viable por compresi\u00f3n directa, buenos valores de resistencia a la rotura, ligera mejora en tiempos de disgregaci\u00f3n con la adici\u00f3n del superdigregante, siendo el mecanismo principal de disgregaci\u00f3n del ac-di-sol el de hinchamiento, y, en todos los casos, la disoluci\u00f3n del pa utilizado claramente mostraba un comportamiento ph-dependiente.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Dise\u00f1o y formulaci\u00f3n de comprimidos de disgregaci\u00f3n inmediata de aceclofenaco.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Dise\u00f1o y formulaci\u00f3n de comprimidos de disgregaci\u00f3n inmediata de aceclofenaco. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Cristina Guerrero Ar\u00e9valo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Sevilla<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/07\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>castellanos M. Jim\u00e9nez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Blanco m\u00e9ndez <\/li>\n<li> Vela Garc\u00eda M\u00aa teresa (vocal)<\/li>\n<li>helena Colom medina (vocal)<\/li>\n<li> Paredes g\u00f3mez pedro Jos\u00e9 (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Cristina Guerrero Ar\u00e9valo El objetivo de la presente tesis doctoral ha sido dirigido hacia la obtenci\u00f3n de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,332,957,3304,50957,2470,1125,10715,1126],"tags":[57711,57710,57712,21090,57713,40317],"class_list":["post-18641","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-ciencias-tecnologicas","category-farmacologia","category-preparacion-de-farmacos","category-procesos-de-liofilizacion","category-procesos-tecnologicos","category-propiedades-de-materiales","category-sevilla","category-tecnologia-de-materiales","tag-castellanos-m-jimenez","tag-cristina-guerrero-arevalo","tag-helena-colom-medina","tag-jose-blanco-mendez","tag-paredes-gomez-pedro-jose","tag-vela-garcia-ma-teresa"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/18641","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=18641"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/18641\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=18641"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=18641"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=18641"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}