{"id":18691,"date":"2018-03-09T09:07:20","date_gmt":"2018-03-09T09:07:20","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/implicaciones-sertonergicas-cardiovasculares-en-el-tren-posterior-de-rata-anestesiada\/"},"modified":"2018-03-09T09:07:20","modified_gmt":"2018-03-09T09:07:20","slug":"implicaciones-sertonergicas-cardiovasculares-en-el-tren-posterior-de-rata-anestesiada","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/implicaciones-sertonergicas-cardiovasculares-en-el-tren-posterior-de-rata-anestesiada\/","title":{"rendered":"Implicaciones sertonergicas cardiovasculares en el tren posterior de rata anestesiada"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Elena Calama Marcos <\/strong><\/h2>\n<p>En este estudio hemos caracterizado las respuestas inducidas por 5-hidroxitriptamina en el tres posterior autoperfundido de rata as\u00ed como los receptores implicados en estas respuestas. Tambi\u00e9n estudiamos la relaci\u00f3n entre el sistema sereoton\u00e9rgico y la neurotransmisi\u00f3n andren\u00e9rgica en el territorio vascular del tren posterior.  utilizando agonistas y antagonistas selectivos de los diferentes tipos y subtipos de receptores seroton\u00e9rgicos mostramos que 5-ht induce vasoconstricci\u00f3n mediada principalmente por receptores 5-ht2a (ya que el agonista de este tipo de receptores, alfa-metil-5-ht, reproduce esta acci\u00f3n que fue inhibida por espiperona, antagonista que bloque los receptores 5-ht2a), las respuestas vasodilatadoras est\u00e1n mediadas principalmente por receptores 5-ht1d (ya que estas respuestas son reproducidas por el agonista de receptores 5-ht1d, l694,247 y bloqueadas por el antagonista de este subtipo de receptores brl 15572. La activaci\u00f3n de este subtipo de receptor da lugar a una liberaci\u00f3n de adrenalina que act\u00faa sobre los receptores beta2 puesto que un antagonista selectivo de estos receptores, ici 118,551 tambi\u00e9n inhibe estas respuestas vasodilatadoras observadas en el tren posterior de ratas normotensas.  a diferencia de las ratas normotensas, en las hipertensas solo observamos respuesta vasoconstrictoras que son m\u00e1s potentes aunque tambi\u00e9n est\u00e1n mediadas por receptores 5-ht2.  adem\u00e1s, de acuerdo con nuestros estudios podemos concluir que la administraci\u00f3n intraarterial de 5-ht (empleando la metodolog\u00eda del tren posterior autoperfundido) indujo similares respuestas a cuando administramos v\u00eda intravenosa esta amina y empleamos la medida directa de flujo vascular mediante una sonda perivascular en el tres posterior.  tambi\u00e9n deducimos que 5-ht inhibe la liberaci\u00f3n de noradrennalina en el tres posterior y esta acci\u00f3n est\u00e1 mediada por receptores 5-ht 1d presin\u00e1pticos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Implicaciones sertonergicas cardiovasculares en el tren posterior de rata anestesiada<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Implicaciones sertonergicas cardiovasculares en el tren posterior de rata anestesiada <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Elena Calama Marcos <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 24\/07\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Luis San Rom\u00e1n Del Barrio<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  S\u00e1nchez de la cuesta felipe <\/li>\n<li>Jos\u00e9 Juan Garcia marin (vocal)<\/li>\n<li>julio Cortijo gimeno (vocal)<\/li>\n<li>matilde Sierra vega (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Elena Calama Marcos En este estudio hemos caracterizado las respuestas inducidas por 5-hidroxitriptamina en el tres posterior [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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