{"id":18723,"date":"2018-03-09T09:07:23","date_gmt":"2018-03-09T09:07:23","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-la-ciclosporina-a-sobre-la-farmacocinetica-del-etoposido\/"},"modified":"2018-03-09T09:07:23","modified_gmt":"2018-03-09T09:07:23","slug":"efecto-de-la-ciclosporina-a-sobre-la-farmacocinetica-del-etoposido","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/efecto-de-la-ciclosporina-a-sobre-la-farmacocinetica-del-etoposido\/","title":{"rendered":"Efecto de la ciclosporina a sobre la farmacocin\u00e9tica del etop\u00f3sido"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jaime C\u00e1rcel Trullols <\/strong><\/h2>\n<p>Se han realizado estudios \u00abin vitro\u00bb con el fin de valorar la citotoxicidad del etop\u00f3sido frente a diferentes l\u00edneas celulares de neuroblastoma, tres l\u00edneas humanas (kcn, ngp y shep) y una l\u00ednea de rata (b 104), con diferentes marcadores gen\u00e9ticos. En los mismos estudios se ha comparado la citotoxicidad producida por una exposici\u00f3n de una hora a concentraciones elevadas de etop\u00f3sido con la citotoxicidad producida por concentraciones bajas de citost\u00e1tico mantenidas durante varios d\u00edas sobre las l\u00edneas celulares de neuroblastoma antes referidas. La inhibici\u00f3n del crecimiento celular resultante de la acci\u00f3n del etop\u00f3sido se determin\u00f3 mediante un ensayo mtt.  de los ensayos efectuados \u00abin vitro\u00bb se concluy\u00f3:  1,- la exposici\u00f3n continua de c\u00e9lulas de neuroblastoma a concentraciones bajas de etop\u00f3sido permite alcanzar una inhibici\u00f3n del crecimiento celular semejante a la obtenida con concentraciones elevadas mantenidas durante un corto espacio de tiempo.  2,- el etop\u00f3sido era m\u00e1s citot\u00f3xico frente a las l\u00edneas de neuroblastoma con amplificaci\u00f3n del oncog\u00e9n n-myc (ngp y kcn) que frente a l\u00ednea de neurobastoma que no presenta dicha amplificaci\u00f3n (shep).  se ha estudiado \u00abin vitro\u00bb, utilizando la rata (rata wistar) como modelo animal de experimentaci\u00f3n, el posible aumento de la distribuci\u00f3n a tejidos del etop\u00f3sido al ser administrado junto a un modulador de la glicoprote\u00edna p (ciclosporina a). La glicoproteina p, una bomba situada en la membrana celular que se encarga de expulsar los xenobi\u00f3ticos del interior celular, tiene un papel importante en la fisiolog\u00eda normal de la c\u00e9lula y es uno de los mecanismos de resistencia m\u00e1s importante frente a agentes anticancerosos.  las ratas fueron canuladas en una o en ambas venas yugulares, dependiendo del tipo de administraci\u00f3n, a fin de tomar muestras de sangre y administrar los f\u00e1rmacos. Los f\u00e1rmacos se administraron en forma de bolo intravenoso o de perfusi\u00f3n in<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto de la ciclosporina a sobre la farmacocin\u00e9tica del etop\u00f3sido<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto de la ciclosporina a sobre la farmacocin\u00e9tica del etop\u00f3sido <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jaime C\u00e1rcel Trullols <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 25\/07\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Esteban Peris Ribera<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: adela Mart\u00edn villodr\u00e9 <\/li>\n<li> Dios vietez Mar\u00eda  del carmen (vocal)<\/li>\n<li>victoria Castel sanchez (vocal)<\/li>\n<li> Torres suarez Ana isabel (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jaime C\u00e1rcel Trullols Se han realizado estudios \u00abin vitro\u00bb con el fin de valorar la citotoxicidad del [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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