{"id":18733,"date":"2018-03-09T09:07:23","date_gmt":"2018-03-09T09:07:23","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-diferentes-mecanismos-de-translocacion-bacteriana-en-un-modelo-de-cirrosis-hepatica-experimental\/"},"modified":"2018-03-09T09:07:23","modified_gmt":"2018-03-09T09:07:23","slug":"estudio-de-diferentes-mecanismos-de-translocacion-bacteriana-en-un-modelo-de-cirrosis-hepatica-experimental","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-de-diferentes-mecanismos-de-translocacion-bacteriana-en-un-modelo-de-cirrosis-hepatica-experimental\/","title":{"rendered":"Estudio de diferentes mecanismos de translocaci\u00f3n bacteriana en un modelo de cirrosis hep\u00e1tica experimental"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Vicente Lorenzo-z\u00fa\u00f1iga Garc\u00eda <\/strong><\/h2>\n<p>La translocaci\u00f3n bacteriana se define como el paso de bacterias viables desde la luz del tracto gastrointestinal hacia los ganglios linf\u00e1ticos mesent\u00e9ticos y otras localizaciones extraintestinales sin ruptura de la pared intestinal; dicho fen\u00f3meno es frecuente en la cirrosis, y son varios los factores que favorecen su aparici\u00f3n: sobrecrecimiento bacteriano intestinal, alteraci\u00f3n de la integridad de la barrera epitelial intestinal, deterioro del sistema inmune de defensa, y la malnutrici\u00f3n.  comprobar la utilidad de dos nuevos tratamientos: igf-i y \u00e1cidos biliares conjugados (colisarcosina y coliglicina), que sirvan como alternativa y\/o complemento al uso de antibi\u00f3tico en la prevenci\u00f3n de la translocaci\u00f3n bacteriana, es un modelo de cirrosis experimental; ya que la descontaminaci\u00f3n intestinal selectiva con antibi\u00f3ticos ocasiona la aparici\u00f3n de g\u00e9rmenes resistentes a los antibi\u00f3ticos.  la administraci\u00f3n de los dos tipos de \u00e1cidos biliares conjutados (colisarcosina y coliglicina), a ratas cirr\u00f3ticas con ascitis produce un incremento en la secreci\u00f3n de bilis y modifica la composici\u00f3n de la misma, al tiempo que se reduce de una forma estad\u00edsticamente significativa la incidencia de translocaci\u00f3n bacteriana, la endotoxemia y la mortalidad. Por tanto, los \u00e1cidos biliares conjugados podr\u00edan ser \u00fatiles en la prevenci\u00f3n de la pbe en los pacientes cirr\u00f3ticos.  la suplementaci\u00f3n terap\u00e9utica con dosis bajas de igf-i es capaz de reducir de una forma estad\u00edsticamente significativa la fibrosis hep\u00e1tica y la presi\u00f3n portal, tanto en ratas con cirrosis compensada como en aquellas ratas cirr\u00f3ticas con ascitis; en cambio, igf-i s\u00f3lo es capaz de reducir de una forma estad\u00edsticamente significativa la incidencia de translocaci\u00f3n bacteriana y la endotoxemia en el estad\u00edo de cirrosis precoz. Por tanto, igf-i podr\u00eda ser un tratamiento en el manejo de la hipertensi\u00f3n portal del paciente cirr\u00f3tico.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de diferentes mecanismos de translocaci\u00f3n bacteriana en un modelo de cirrosis hep\u00e1tica experimental<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de diferentes mecanismos de translocaci\u00f3n bacteriana en un modelo de cirrosis hep\u00e1tica experimental <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Vicente Lorenzo-z\u00fa\u00f1iga Garc\u00eda <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 26\/07\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Vicente Lorenzo Z\u00fa\u00f1iga<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jes\u00fas m. Prieto valtue\u00f1a <\/li>\n<li>evaristo Varo p\u00e9rez (vocal)<\/li>\n<li>angel Alvarez prechous (vocal)<\/li>\n<li>Mar\u00eda  de los \u00e1ngeles Castro iglesias (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Vicente Lorenzo-z\u00fa\u00f1iga Garc\u00eda La translocaci\u00f3n bacteriana se define como el paso de bacterias viables desde la luz [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[155,9,491,139,597,977],"tags":[21053,43888,15059,21466,35246,57933],"class_list":["post-18733","post","type-post","status-publish","format-standard","hentry","category-ciencias-clinicas","category-ciencias-medicas","category-gastroenterologia","category-medicina-interna","category-microbiologia-clinica","category-santiago-de-compostela","tag-angel-alvarez-prechous","tag-evaristo-varo-perez","tag-jesus-m-prieto-valtuena","tag-maria-de-los-angeles-castro-iglesias","tag-vicente-lorenzo-zuniga","tag-vicente-lorenzo-zuniga-garcia"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/18733","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=18733"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/18733\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=18733"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=18733"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=18733"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}