{"id":18774,"date":"2018-03-09T09:07:27","date_gmt":"2018-03-09T09:07:27","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-del-17-beta-estradiol-sobre-la-sensibilidad-de-tejidos-diana-a-la-accion-de-la-insulina-en-la-rata-modulacion-de-la-ruta-de-senalizacion-intracelular-de-la-insulina\/"},"modified":"2018-03-09T09:07:27","modified_gmt":"2018-03-09T09:07:27","slug":"efectos-del-17-beta-estradiol-sobre-la-sensibilidad-de-tejidos-diana-a-la-accion-de-la-insulina-en-la-rata-modulacion-de-la-ruta-de-senalizacion-intracelular-de-la-insulina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/efectos-del-17-beta-estradiol-sobre-la-sensibilidad-de-tejidos-diana-a-la-accion-de-la-insulina-en-la-rata-modulacion-de-la-ruta-de-senalizacion-intracelular-de-la-insulina\/","title":{"rendered":"Efectos del 17 beta-estradiol sobre la sensibilidad de tejidos diana a la acci\u00f3n de la insulina en la rata. modulaci\u00f3n de la ruta de se\u00f1alizaci\u00f3n intracelular de la insulina"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ana Alonso Garc\u00eda <\/strong><\/h2>\n<p>Apenas se dispone de informaci\u00f3n sobre los mecanismos moleculares responsables de la relaci\u00f3n entre insulina y esteroides sexuales. En este trabajo hemos intentado clarificar el papel del 17beta-estradiol sobre los cambios en la sensibilidad a la acci\u00f3n de la insulina caracterizado los primeros pasos de la cascada de se\u00f1alizaci\u00f3n insul\u00ednica en la rata. Utilizamos ratas ovariectomizadas tratadas con distintas dosis de 17beta-estradiol.  comprobamos que el 17beta-estradiol modula la sensibilidad a la acci\u00f3n de la insulina de forma dosis-dependiente. Tambi\u00e9n hemos observado que el 17beta-estradiol es capaz de modular la ruta de se\u00f1alizaci\u00f3n intracelular de la insulina, controlando no s\u00f3lo la expresi\u00f3n de los genes del receptor de insulina y de su principal sustrato, irs-1, sino tambi\u00e9n la cantidad de sus respectivas prote\u00ednas y la asociaci\u00f3n entre irs-1 y el enzima fosfoatidilinositol-3-quinasa (pi3-quinasa), de manera dependiente de tejido.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos del 17 beta-estradiol sobre la sensibilidad de tejidos diana a la acci\u00f3n de la insulina en la rata. modulaci\u00f3n de la ruta de se\u00f1alizaci\u00f3n intracelular de la insulina<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos del 17 beta-estradiol sobre la sensibilidad de tejidos diana a la acci\u00f3n de la insulina en la rata. modulaci\u00f3n de la ruta de se\u00f1alizaci\u00f3n intracelular de la insulina <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ana Alonso Garc\u00eda <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Oviedo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 29\/07\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Celestino Gonzalez Gonzalez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: m Patterson angeles <\/li>\n<li>Jos\u00e9 enrique Campillo \u00e1lvarez (vocal)<\/li>\n<li>Emilio Herrera castrill\u00f3n (vocal)<\/li>\n<li>agust\u00edn Hidalgo balsera (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ana Alonso Garc\u00eda Apenas se dispone de informaci\u00f3n sobre los mecanismos moleculares responsables de la relaci\u00f3n entre [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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