{"id":18847,"date":"2002-06-09T00:00:00","date_gmt":"2002-06-09T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/la%c2%adpidos-de-la-dieta-y-cancer-de-mama-experimental-carcinogenesis-y-regulacion-de-la-expresion-genica\/"},"modified":"2002-06-09T00:00:00","modified_gmt":"2002-06-09T00:00:00","slug":"la%c2%adpidos-de-la-dieta-y-cancer-de-mama-experimental-carcinogenesis-y-regulacion-de-la-expresion-genica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/la%c2%adpidos-de-la-dieta-y-cancer-de-mama-experimental-carcinogenesis-y-regulacion-de-la-expresion-genica\/","title":{"rendered":"L\u00edpidos de la dieta y c\u00e1ncer de mama experimental: carcinog\u00e9nesis y regulaci\u00f3n de la expresi\u00f3n g\u00e9nica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Raquel Moral Cabrera <\/strong><\/h2>\n<p>El c\u00e1ncer de mama es el m\u00e1s frecuente en mujeres de pa\u00edses desarrollados. entre los distintos factores que incluyen en este proceso neopl\u00e1sico, destacan los nutricionales y especialmente los l\u00edpidos de la dieta. En este trabajo se ha analizado el efecto modulador de los l\u00edpidos poliinsaturados n-6 (aceite de ma\u00edz) y monoinsaturados n-9 (aceite de oliva) de la dieta sobre la carcinog\u00e9nesis mamaria inducida en la rata sprague-dawley mediante dmba.  el an\u00e1lisis de los par\u00e1metros de la carcinog\u00e9nesis ha mostrado que la dieta hiperlip\u00eddica de ma\u00edz ejerce un claro efecto estimulador del c\u00e1ncer de mama experimental, que se manifiesta en un comportamiento cl\u00ednico m\u00e1s maligno de los tumores respecto a la dieta normolip\u00eddica (aparici\u00f3n m\u00e1s r\u00e1pida de los tumores, mayor n\u00famero de animales afectados, mayor contenido y masa tumorales, caracter\u00edsticas histopatol\u00f3gicas compatibles con un mayor grado de malignidad). Adem\u00e1s, este efecto podr\u00eda producirse tanto a nivel de la promoci\u00f3n como de la iniciaci\u00f3n de la tumorig\u00e9nesis mamaria. En cuanto a la dieta hiperlip\u00eddica de oliva, ha mostrado un efecto fundamentalmente protector de la carcinog\u00e9nesis mamaria experimental: no acelera  la aparici\u00f3n de los tumores y disminuye la cantidad y el crecimiento de los mismos en relaci\u00f3n a la dieta control.  por otro lado, se han estudiado mecanismos a trav\u00e9s de los cuales los l\u00edpidos podr\u00edan ejercer sus efectos moduladores de la carcinog\u00e9nesis mamaria experimental. se ha analizado la frecuencia y la incidencia de la mutaci\u00f3n puntual en el segundo nucle\u00f3tido del cod\u00f3n 61 de c-has-ras1, y los resultados obtenidos han sugerido un efecto de los distintos tipos de l\u00edpidos sobre subpoblaciones tumorales diferentes: promotor fundamentalmente sobre las c\u00e9lulas portadoras de la mutaci\u00f3n, en el caso del aceite de ma\u00edz, e inhibidor principalmente sobre las c\u00e9lulas sin la mutaci\u00f3n, en el caso del aceite de oliva. Por otra parte, se ha re<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>L\u00edpidos de la dieta y c\u00e1ncer de mama experimental: carcinog\u00e9nesis y regulaci\u00f3n de la expresi\u00f3n g\u00e9nica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 L\u00edpidos de la dieta y c\u00e1ncer de mama experimental: carcinog\u00e9nesis y regulaci\u00f3n de la expresi\u00f3n g\u00e9nica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Raquel Moral Cabrera <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 06\/09\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Eduard Escrich Escriche<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: bonifacio nicol\u00e1s Diaz chico <\/li>\n<li>Carlos Ciudad g\u00f3mez (vocal)<\/li>\n<li>Fernando Dom\u00ednguez cunchillos (vocal)<\/li>\n<li>miquel Borras suarez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Raquel Moral Cabrera El c\u00e1ncer de mama es el m\u00e1s frecuente en mujeres de pa\u00edses desarrollados. entre [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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