{"id":18878,"date":"2002-10-09T00:00:00","date_gmt":"2002-10-09T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/implicacion-de-la-glicoprotea%c2%adna-p-y-la-utilizacion-de-inhibidores-metabolicos-en-el-aumento-de-la-biodisponibilidad-del-albendazol-sulfoxido\/"},"modified":"2002-10-09T00:00:00","modified_gmt":"2002-10-09T00:00:00","slug":"implicacion-de-la-glicoprotea%c2%adna-p-y-la-utilizacion-de-inhibidores-metabolicos-en-el-aumento-de-la-biodisponibilidad-del-albendazol-sulfoxido","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/implicacion-de-la-glicoprotea%c2%adna-p-y-la-utilizacion-de-inhibidores-metabolicos-en-el-aumento-de-la-biodisponibilidad-del-albendazol-sulfoxido\/","title":{"rendered":"Implicaci\u00f3n de la glicoprote\u00edna p y la utilizaci\u00f3n de inhibidores metab\u00f3licos en el aumento de la biodisponibilidad del albendazol sulf\u00f3xido"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Gracia Merino Pel\u00e1ez <\/strong><\/h2>\n<p>El albendazol (abz) es un antiparasitario utilizado en medicina humana y veterinaria. Presenta problemas a la hora de su administraci\u00f3n debido a su baja solubilidad y a su escasa absorci\u00f3n en el tracto gastrointestinal. el abz se metaboliza r\u00e1pidamente tras administraci\u00f3n oral en su metabolito activo: albendazol sulf\u00f3xido (abzso) que a su vez se oxida form\u00e1ndose albendazol sulfona (abzso2). En el presente trabajo se ha aumentado la biodisponibilidad del abzso mediante la utilizaci\u00f3n de inhibidores del metabolismo y de la glicoprote\u00edna p, un transportador de membrana que exporta hacia fuera de la c\u00e9lula diversos compuestos y que pude estar implicado en la eliminaci\u00f3n del abzso a nivel intestinal.  en primer lugar, se estudi\u00f3 la interacci\u00f3n entre la glicoprote\u00edna p y el abz tanto en cultivos celulares (l\u00edneas llcpk-1, l-mdr1 y caco-2) como en ratones knock-out que no expresan la glicoprote\u00edna p. Los resultados mostraron que el abz no era sustrato de la glicoprote\u00edna p. Sin embargo, determinadas evidencias experimentales sugirieron que el abzso pudiera ser sustrato de la glicoprote\u00edna p. Sobre esta base, se utiliz\u00f3 un modelo de perfusi\u00f3n intestinal para demostrar la eliminaci\u00f3n del abzso, que result\u00f3 ser enantioselectiva. Este f\u00e1rmaco se administr\u00f3 por v\u00eda intravenosa de forma \u00fanica y coadministrado con otros f\u00e1rmcos (verapamilo, ciclosporina, oxfendazol, ampicilina, glibenclamida, floretina, insulina y ginseng: adem\u00e1s de la presencia de glucosa en el perfusado intestinal) para elucidar el mecanismo implicado en el proceso. Se demostr\u00f3 la existencia de un sistema de transporte dependiente de energ\u00eda y glucosa y la participaci\u00f3n de la glicoprote\u00edna p. Tambi\u00e9n se realizaron estudios farmacocin\u00e9ticos tras la coadministraci\u00f3n de abz y de inhibidores de la glicoprote\u00edna p (verapamilo, quinidina e ivermectina) en rata y oveja, observ\u00e1ndose un aumento de la biodisponibilidad del abzso en los grupos con inhibidores<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Implicaci\u00f3n de la glicoprote\u00edna p y la utilizaci\u00f3n de inhibidores metab\u00f3licos en el aumento de la biodisponibilidad del albendazol sulf\u00f3xido<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Implicaci\u00f3n de la glicoprote\u00edna p y la utilizaci\u00f3n de inhibidores metab\u00f3licos en el aumento de la biodisponibilidad del albendazol sulf\u00f3xido <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Gracia Merino Pel\u00e1ez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Le\u00f3n<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 10\/09\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Prieto Fern\u00e1ndez Julio Gabriel<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: adela Mart\u00edn villodr\u00e9 <\/li>\n<li>carles Crist\u00f3fol adell (vocal)<\/li>\n<li>Ana isabel Alcalde herrero (vocal)<\/li>\n<li> Garc\u00eda llamazares Jos\u00e9 Luis (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gracia Merino Pel\u00e1ez El albendazol (abz) es un antiparasitario utilizado en medicina humana y veterinaria. Presenta problemas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9481,494,9,515,189,957,6530,5675,1927,4430],"tags":[12340,44844,41056,58315,58313,58314],"class_list":["post-18878","post","type-post","status-publish","format-standard","hentry","category-absorcion-de-los-farmacos","category-ciencias-agrarias","category-ciencias-medicas","category-ciencias-veterinarias","category-farmacodinamia","category-farmacologia","category-farmacologia-experimental","category-farmacologia-veterinaria","category-fisiologia-veterinaria","category-leon","tag-adela-martin-villodre","tag-ana-isabel-alcalde-herrero","tag-carles-cristofol-adell","tag-garcia-llamazares-jose-luis","tag-gracia-merino-pelaez","tag-prieto-fernandez-julio-gabriel"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/18878","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=18878"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/18878\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=18878"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=18878"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=18878"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}