{"id":18915,"date":"2002-12-09T00:00:00","date_gmt":"2002-12-09T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/mutaciones-de-resistencia-en-pacientes-que-fracasan-con-un-regimen-antirretroviral-que-incluye-nelfinavir\/"},"modified":"2002-12-09T00:00:00","modified_gmt":"2002-12-09T00:00:00","slug":"mutaciones-de-resistencia-en-pacientes-que-fracasan-con-un-regimen-antirretroviral-que-incluye-nelfinavir","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/mutaciones-de-resistencia-en-pacientes-que-fracasan-con-un-regimen-antirretroviral-que-incluye-nelfinavir\/","title":{"rendered":"Mutaciones de resistencia en pacientes que fracasan con un r\u00e9gimen antirretroviral que incluye nelfinavir"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Esperanza Casas Garc\u00eda <\/strong><\/h2>\n<p>Introducci\u00f3n  la selecci\u00f3n de mutaciones de resistencia a los f\u00e1rmacos antirretrovirales (arv) es una de las causas principales de fracaso terap\u00e9utico en la infecci\u00f3n vih y puede condicionar la eficacia del r\u00e9gimen de rescate. La posibilidad de resistencia cruzada es particularmente importante entre los inhibidores de la proteasa (ip). Las mutaciones primarias del nelfinavir (nfv) son d30n y l90m. La primera reduce la capacidad replicativa viral y no conlleva resistencia cruzada a otros ip; la segunda confiere resistencia a todos los ip.  objetivos  mediante la utilizaci\u00f3n de pruebas de resistencia genot\u00edpica, nos planteamos:  1,- evaluar la frecuencia.  2,- describir el perfil de mutaciones de resistencia que aparecen en el primer rebrote de viremia en pacientes con infecci\u00f3n vih que experimentan un fracaso virol\u00f3gico con un r\u00e9gimen antirretroviral que incluye nfv como primer ip.  pacientes y m\u00e9todos  se analizaron las muestras de plasma del primer rebrote de viremia de enfermos con infecci\u00f3n vih que recib\u00edan una combinaci\u00f3n de tres f\u00e1rmacos arv que inclu\u00eda nfv como primer ip, en seis hospitales del pa\u00eds. La viremia plasm\u00e1tica (rna-vih) se cuantific\u00f3 utilizando el m\u00e9todo de branched-dna de tercera generaci\u00f3n (quantiplex 3.0, bayer, barcelona, espa\u00f1a). La detecci\u00f3n de mutaciones de resistencia a los f\u00e1rmacos arv se realiz\u00f3 mediante el m\u00e9todo de secuenciaci\u00f3n autom\u00e1tica viroseq hiv-1 genotyping system (applied biosystems, foster city, ca).  resultados  se incluyeron en el estudio 30 pacientes. El 73% eran varones, la mediana edad fue de 35 a\u00f1os. El 43% de los enfermos era usuario de drogas intravenosas. la duraci\u00f3n del tratamiento arv antes del fracaso terap\u00e9utico fue de 4-32 meses. La viremia mediana en el momento del an\u00e1lisis era de 4.180 copias de vih\/ml. Los productos de amplificaci\u00f3n mediante pcr fueron obtenidos en s\u00f3lo 22 de los 30 enfermos. Las mutaciones de resistencia primaria a ip<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Mutaciones de resistencia en pacientes que fracasan con un r\u00e9gimen antirretroviral que incluye nelfinavir<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Mutaciones de resistencia en pacientes que fracasan con un r\u00e9gimen antirretroviral que incluye nelfinavir <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Esperanza Casas Garc\u00eda <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 12\/09\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Vicente Soriano V\u00e1zquez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  jos\u00e9 V\u00e1zquez rodr\u00edguez <\/li>\n<li>Juan Gonz\u00e1lez lahoz (vocal)<\/li>\n<li>Francisco Arnalich fern\u00e1ndez (vocal)<\/li>\n<li>joaqu\u00edn L\u00f3pez \u00e1lvarez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Esperanza Casas Garc\u00eda Introducci\u00f3n la selecci\u00f3n de mutaciones de resistencia a los f\u00e1rmacos antirretrovirales (arv) es una [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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