{"id":18929,"date":"2018-03-09T09:07:42","date_gmt":"2018-03-09T09:07:42","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/sefectos-del-tratamiento-cronico-con-nebivolol-sobre-las-alteraciones-cardiovasculares-funcionales-y-estructurales-en-ratas-espontaneamente-hipertensas\/"},"modified":"2018-03-09T09:07:42","modified_gmt":"2018-03-09T09:07:42","slug":"sefectos-del-tratamiento-cronico-con-nebivolol-sobre-las-alteraciones-cardiovasculares-funcionales-y-estructurales-en-ratas-espontaneamente-hipertensas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/sefectos-del-tratamiento-cronico-con-nebivolol-sobre-las-alteraciones-cardiovasculares-funcionales-y-estructurales-en-ratas-espontaneamente-hipertensas\/","title":{"rendered":"Sefectos del tratamiento cr\u00f3nico con nebivolol sobre las alteraciones cardiovasculares funcionales y estructurales en ratas espont\u00e1neamente hipertensas"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Guerrero De Le\u00f3n Estela Ivonne <\/strong><\/h2>\n<p>Se investig\u00f3 en ratas espont\u00e1neamente hipertensas el efecto del tratamiento cr\u00f3nico con nebivolol sobre las alteraciones cardiovasculares que se presentan en la hipertensi\u00f3n arterial.  se establecieron tratamientos a medio plazo (2 meses) y largo plazo (6 meses) con 2, 8 y 20 mg\/kg\/d\u00eda de nebivolol. Un tercer periodo de estudio se estableci\u00f3 para determinar si los efectos durante 6 meses de tratamiento se manten\u00edan tres meses despu\u00e9s de suprimir la administraci\u00f3n del f\u00e1rmaco.  la eficacia antihipertensiva se control\u00f3  midiendo la presi\u00f3n arterial y frecuencia cardiaca por el m\u00e9todo incruento de medida en la cola y finalizados los tratamientos se realizaron estudios de funcionalidad en anillos de arteria aorta y lecho mesent\u00e9rico perfundido y se procesaron muestras de aorta y coraz\u00f3n para realizar estudios morfom\u00e9tricos y de fibrosis.  el tratamiento con nebivolol reduce los valores de presi\u00f3n arterial de forma dosis-dependiente. Este efecto se acompa\u00f1a de una mejora de la funcionalidad vascular, tanto en arterias de resistencia como de conductancia, que se refleja en una mayor respuesta relajante a acetilcolina y una mayor respuesta relajante a acetilcolina y una menor respuesta contracturante a noradrenalina y kcl. Los estudios histol\u00f3gicos muestran que el tratamiento durante 2 y 6 meses con las tres dosis de nebivolol ensayadas, logran reducir el grosor de la capa media de la aorta y la deposici\u00f3n de col\u00e1geno y que el efecto se mantiene 3 meses despu\u00e9s de retirar el f\u00e1rmaco.  la reducci\u00f3n de la hipertrofia ventricular y la deposici\u00f3n de col\u00e1geno observados a los 6 meses de tratamiento con se mantienen a\u00fan despu\u00e9s de 3 meses de retirar el f\u00e1rmaco.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Sefectos del tratamiento cr\u00f3nico con nebivolol sobre las alteraciones cardiovasculares funcionales y estructurales en ratas espont\u00e1neamente hipertensas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Sefectos del tratamiento cr\u00f3nico con nebivolol sobre las alteraciones cardiovasculares funcionales y estructurales en ratas espont\u00e1neamente hipertensas <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Guerrero De Le\u00f3n Estela Ivonne <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 13\/09\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda  Jose Montero G\u00f3mez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Luis San rom\u00e1n del barrio <\/li>\n<li>julio Juan G\u00e1lvez peralta (vocal)<\/li>\n<li>ceferino S\u00e1nchez jorquera (vocal)<\/li>\n<li> Tejer\u00edan s\u00e1nchez M\u00aa teresa (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Guerrero De Le\u00f3n Estela Ivonne Se investig\u00f3 en ratas espont\u00e1neamente hipertensas el efecto del tratamiento cr\u00f3nico con [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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