{"id":18935,"date":"2018-03-09T09:07:43","date_gmt":"2018-03-09T09:07:43","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-fenota%c2%adpico-de-mutantes-de-candida-albicans-para-el-gen-cyc3-que-codifica-para-la-enzima-citocromo-c-hemoliasa\/"},"modified":"2018-03-09T09:07:43","modified_gmt":"2018-03-09T09:07:43","slug":"estudio-fenota%c2%adpico-de-mutantes-de-candida-albicans-para-el-gen-cyc3-que-codifica-para-la-enzima-citocromo-c-hemoliasa","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/estudio-fenota%c2%adpico-de-mutantes-de-candida-albicans-para-el-gen-cyc3-que-codifica-para-la-enzima-citocromo-c-hemoliasa\/","title":{"rendered":"Estudio fenot\u00edpico de mutantes de candida albicans para el gen cyc3 que codifica para la enzima citocromo c-hemoliasa"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Flores Y\u00e1\u00f1ez M. Consuelo <\/strong><\/h2>\n<p>En el presente trabajo se ha procedido a realizar un estudio comparativo de determinadas caracter\u00edsticas estructurales y bioqu\u00edmicas (hidrofobicidad de la superficie celular, adherencia a componentes de la matriz extracelular de mam\u00edferos- laminina, fibronectina, col\u00e1geno- y del plasma -fibrin\u00f3geno), as\u00ed como la producci\u00f3n de una proteasa \u00e1cida y fosfolipasa que parecen jugar un papel importante como determinantes (factores) de virulencia en el hongo dim\u00f3rfico, pat\u00f3geno oportunista, candida albicans, en cepas mutantes de dicho microorganismo que tienen disrupciones en hetrocigosis (acci2) o en homocigosis (acci4) del gen cyc3, que codifica la s\u00edntesis tanto de una enzima citocromo c-hemolilasa presente en las mitocondrias, como de una prote\u00edna integral de la pared celular de ambas formas (levadura y micelio) del hongo. Adem\u00e1s se obtuvieron curvas de supervivencia en ratones inmunocompetentes y neutrop\u00e9nicos, inoculados por la vena lateral de la cola con cada una de las cepas en estudio. Paralelamente a estos estudios de virulencia se sacrificaron dos individuos de cada grupo a las 24,48 y 72 horas, separando los ri\u00f1ones y el h\u00edgado para su an\u00e1lisis histopatol\u00f3gico y para determinar el n\u00famero de microorganismos (unidades formadoras de colonias-ufc-). En general, los resultados obtenidos indican que las cepas con disrupciones en una o en las dos copias del gen cyc3 tienen una menor capacidad para adherirse a los componentes del suero y la matriz extracelular, una menor hidrofobicidad superficial y unos niveles m\u00e1s bajos de actividad hidrol\u00edtica, en comparaci\u00f3n con la cepa parental (cai4) a partir de la cual se obtuvieron. las cepas en estudio no causaron la muerte en ning\u00fan grupo al cabo de los 28 d\u00edas en ratones inmunocompetentes y 10 d\u00edas en ratones neutrop\u00e9nicos, no observ\u00e1ndose colonizaci\u00f3n de tejidos, as\u00ed como recuperaci\u00f3n de ufc al cabo de 48hrs. La postinoculaci\u00f3n intravenosa de una dosis letal de la cepa<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio fenot\u00edpico de mutantes de candida albicans para el gen cyc3 que codifica para la enzima citocromo c-hemoliasa<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio fenot\u00edpico de mutantes de candida albicans para el gen cyc3 que codifica para la enzima citocromo c-hemoliasa <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Flores Y\u00e1\u00f1ez M. Consuelo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 13\/09\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Pedro Martinez Garcia<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: tom\u00e1s Gonz\u00e1lez villa <\/li>\n<li>joaqu\u00edn Timoneda timoneda (vocal)<\/li>\n<li> Del castillo agudo lucas (vocal)<\/li>\n<li>Miguel Vi\u00f1as ciordia (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Flores Y\u00e1\u00f1ez M. Consuelo En el presente trabajo se ha procedido a realizar un estudio comparativo de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[35,984,278],"tags":[58449,58448,19179,1259,1241,2553],"class_list":["post-18935","post","type-post","status-publish","format-standard","hentry","category-ciencias-de-la-vida","category-levaduras","category-microbiologia","tag-del-castillo-agudo-lucas","tag-flores-yanez-m-consuelo","tag-joaquin-timoneda-timoneda","tag-jose-pedro-Martinez-garcia","tag-miguel-vinas-ciordia","tag-tomas-gonzalez-villa"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/18935","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=18935"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/18935\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=18935"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=18935"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=18935"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}