{"id":18936,"date":"2018-03-09T09:07:43","date_gmt":"2018-03-09T09:07:43","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/solubilizacion-de-farmacos-antiinflamatorios-en-aceite-de-silicona-para-su-posible-utilizacion-en-la-profilaxis-de-la-vitreorretinopata%c2%ada-proliferante\/"},"modified":"2018-03-09T09:07:43","modified_gmt":"2018-03-09T09:07:43","slug":"solubilizacion-de-farmacos-antiinflamatorios-en-aceite-de-silicona-para-su-posible-utilizacion-en-la-profilaxis-de-la-vitreorretinopata%c2%ada-proliferante","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/solubilizacion-de-farmacos-antiinflamatorios-en-aceite-de-silicona-para-su-posible-utilizacion-en-la-profilaxis-de-la-vitreorretinopata%c2%ada-proliferante\/","title":{"rendered":"Solubilizaci\u00f3n de f\u00e1rmacos antiinflamatorios en aceite de silicona para su posible utilizaci\u00f3n en la profilaxis de la vitreorretinopat\u00edaproliferante"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda  Esther Zamarron Frailes <\/strong><\/h2>\n<p>Objetivos  * comprobar la solubilidad de dexametasona, acet\u00f3nido de triamcinolona, fenilbutazona, nabumetona e indometacina en silicona, averiguar sus concentraciones de disoluci\u00f3n \u00f3ptima y estudiar su cin\u00e9tica de liberaci\u00f3n \u00abin vitro\u00bb.  * estudiar el posible efecto de citoxicidad celular del aceite de silicona y de los f\u00e1rmacos.  * determinar los niveles de per\u00f3xidos lip\u00eddicos en muestras de retina y cristalino de ojos de conejos tratados con aceite de silicona s\u00f3lo y con los f\u00e1rmacos antiinflamatorios disueltos.  m\u00e9todos  * solubilizaci\u00f3n de los f\u00e1rmacos en el aceite, y preparaci\u00f3n de un sistema \u00abin vitro\u00bb que consist\u00eda en poner en contacto agua con el aceite de silicona en el que se hab\u00eda disuelto el f\u00e1rmaco para estudiar la cin\u00e9tica de liberaci\u00f3n.  * estudio de la citotoxicidad del aceite de silicona mediante la incubaci\u00f3n de dicho aceite con o sin f\u00e1rmacos disueltos con los fibroblastos, midiendo el da\u00f1o celular con el xtt.  * estudiar el efecto sobre la inflamaci\u00f3n intraocular de la utilizaci\u00f3n de aceite de silicona s\u00f3lo o con f\u00e1rmacos disueltos mediante el kit calbiochem.  resultados  * de los f\u00e1rmacos ensayados s\u00f3lo se logro disolver la fenilbutazona a una concentraci\u00f3n \u00f3ptima de 80 m\/l y nabumetona a 2 mg\/l. Su cin\u00e9tica de liberaci\u00f3n es de orden 0, independiente de la concentraci\u00f3n y liber\u00e1ndose a los 15 d\u00edas la mitad de la dosis inicial.  * la citotoxicidad de la silicona es muy alta y no se modifica al adicionar fenilbutazona.  * la concentraci\u00f3n de per\u00f3xidos lip\u00eddicos en retina y cristalino es mucho menor en los ojos tratados con silicona en la que se hab\u00eda disuelto la fenilbutazona, con diferencias estad\u00edsticamente significativas entre los grupos de estudio (con fenilbutazona) y los grupos control (sin fenilbutazona).  conclusiones  * de todos los f\u00e1rmacos ensayados s\u00f3lo se lograron disolver la fenilbutazona y la nabumetona. Su cin\u00e9tica de liberaci\u00f3n es de orden 0 y<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Solubilizaci\u00f3n de f\u00e1rmacos antiinflamatorios en aceite de silicona para su posible utilizaci\u00f3n en la profilaxis de la vitreorretinopat\u00edaproliferante<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Solubilizaci\u00f3n de f\u00e1rmacos antiinflamatorios en aceite de silicona para su posible utilizaci\u00f3n en la profilaxis de la vitreorretinopat\u00edaproliferante <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda  Esther Zamarron Frailes <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Valladolid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 13\/09\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Carlos Pastor Jimeno<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: alfonso Velasco mart\u00edn <\/li>\n<li>roc\u00edo Herreros vanrrell (vocal)<\/li>\n<li>Mar\u00eda  del carmen Cap\u00e9ans tom\u00e9 (vocal)<\/li>\n<li>Francisco G\u00f3mez ulla (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Esther Zamarron Frailes Objetivos * comprobar la solubilidad de dexametasona, acet\u00f3nido de triamcinolona, fenilbutazona, nabumetona e [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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