{"id":18963,"date":"2018-03-09T09:07:45","date_gmt":"2018-03-09T09:07:45","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-del-inhibidor-de-glicosilacion-benzil-galnac-sobre-las-rutas-secretora-y-endoca%c2%adtica-de-celulas-epiteliales\/"},"modified":"2018-03-09T09:07:45","modified_gmt":"2018-03-09T09:07:45","slug":"efectos-del-inhibidor-de-glicosilacion-benzil-galnac-sobre-las-rutas-secretora-y-endoca%c2%adtica-de-celulas-epiteliales","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/efectos-del-inhibidor-de-glicosilacion-benzil-galnac-sobre-las-rutas-secretora-y-endoca%c2%adtica-de-celulas-epiteliales\/","title":{"rendered":"Efectos del inhibidor de glicosilaci\u00f3n benzil galnac sobre las rutas secretora y endoc\u00edtica de c\u00e9lulas epiteliales"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Ulloa Darquea Fausto Alexander <\/strong><\/h2>\n<p>El benzil galnac fue descrito inicialmente como un inhibidor de la o-glicosilaci\u00f3n de tipo mucina (kuan et al., 1989). El tratamiento cr\u00f3nico de c\u00e9lulas mucosecretoras ht-29 m6 con este f\u00e1rmaco produjo una serie de efectos entre los que destacan: i) reducci\u00f3n de la proliferaci\u00f3n, ii) inhibici\u00f3n de la secreci\u00f3n de mucinas, iii) acumulaci\u00f3n de glicoprote\u00ednas apicales en ves\u00edculas citoplasm\u00e1ticas electronl\u00facidas y, iv) reducci\u00f3n de la sialilaci\u00f3n de glicoprote\u00ednas (huet et al., 1998; (hennebicq-reig et al., 1998). El benzil galnac tambi\u00e9n induc\u00eda estos efectos sobre la poblaci\u00f3n ht-29 parental y sobre otras poblaciones celulares derivadas de \u00e9sta, independientemente de su fenotipo. El benzil galnac es metabolizado a benzil galnac-gal, el cual a su vez inhibe competitivamente la actividad a2,3 sialiltransferasa de c\u00e9lulas ht-29, la actividad sialiltransferasa mayoritariamente expresada en estas c\u00e9lulas. Como resultado de \u00e9sto, se sintetizan compuestos sialilados como benzil galnac-gala2, 3neu5ac (huet et al., 1995); delannoy et al., 1996). Por otro lado, el tratamiento con benzil galnac no afectaba sensiblemente a las c\u00e9lulas caco-2, las cuales expresan fundamentalmente a 2.6 sialliltransferasas, enzimas que no son inhibidas por los metabolitos derviados del benzil galnac (huet et al,1998). el objetivo de este trabajo ha sido determinar el factor(es) responsable(s) del origen del fenotipo de c\u00e9lulas ht-29 tratadas cr\u00f3nicamente con benzil galnac. m\u00e1s concretamente, nos interes\u00f3 determinar c\u00f3mo un inhibidor de glicosilaci\u00f3n produce tanto efectos diferentes y si el efecto de este inhibidor estaba restringido o no a c\u00e9lulas derivadas de ht-29. La hip\u00f3tesis que se manej\u00f3 inicialmente propon\u00eda que los efectos globales del tratamiento con benzil galnac podr\u00edan estar causados por lahiposialilaci\u00f3n de glicoprote\u00ednas. Esta hip\u00f3tesis se basaba en el supuesto de que el \u00e1cido si\u00e1lico fuese requerido para el trasnpo<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos del inhibidor de glicosilaci\u00f3n benzil galnac sobre las rutas secretora y endoc\u00edtica de c\u00e9lulas epiteliales<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos del inhibidor de glicosilaci\u00f3n benzil galnac sobre las rutas secretora y endoc\u00edtica de c\u00e9lulas epiteliales <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Ulloa Darquea Fausto Alexander <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/09\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Real<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: carles Enric <\/li>\n<li>dolors Ludevid m\u00fagica (vocal)<\/li>\n<li>angel Alonso Miguel (vocal)<\/li>\n<li>arrate Mallabiabarrena (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ulloa Darquea Fausto Alexander El benzil galnac fue descrito inicialmente como un inhibidor de la o-glicosilaci\u00f3n de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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