{"id":18988,"date":"2018-03-09T09:07:48","date_gmt":"2018-03-09T09:07:48","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/anomala%c2%adas-cromosomicas-y-p53-en-cancer\/"},"modified":"2018-03-09T09:07:48","modified_gmt":"2018-03-09T09:07:48","slug":"anomala%c2%adas-cromosomicas-y-p53-en-cancer","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/anomala%c2%adas-cromosomicas-y-p53-en-cancer\/","title":{"rendered":"Anomal\u00edas cromos\u00f3micas y p53 en c\u00e1ncer"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Arancha Rodr\u00edguez Garc\u00eda <\/strong><\/h2>\n<p>Si bien se ha descrito que, aproximadamente un 50% de tumores humanos presentan mutaciones\/delecciones de la prote\u00edna p53, la mayor\u00eda de \u00e9stos corresponden a tumores de origen mesenquimal, habi\u00e9ndose descrito casos en los que la prote\u00edna est\u00e1 presente, y normal, en tumores de origen mesenquimal.  nuestro proyecto ha intentado responder a la pregunta de por qu\u00e9 una c\u00e9lula tumoral portadora de una anomal\u00eda cromos\u00f3mica y que expresa prote\u00edna p53 normal no muere.  los ensayos realizados parecen indicar que el producto de la anomal\u00eda cromos\u00f3mica ejerce una interferencia con la capacidad transactivadora de la prote\u00edna p53, interferencia que se lleva a cabo de modo funcional, interfiriendo con los coactivadores cbp\/p300 encargados de su activaci\u00f3n. Hemos comprobado como esto se aplica a dem\u00e1s a otros transactivadores transcripcionales dependientes a su vez de cbp\/p300. As\u00ed pues, este mecanismo de interferecnia podr\u00eda considerarse un mecanismo universal en el desarrollo del c\u00e1ncer mesenquimal.  las implicaciones terap\u00e9uticas de nuestros estudios afectan a la actuaci\u00f3n sobre el pool de coactivadores transcripcionales de la c\u00e9lula, y al aumento \u00abcontrolado\u00bb de p53 en c\u00e9lulas tumorales que expresan prote\u00edna p53 y son portadoras de una anomal\u00f3a cromos\u00f3mica, induci\u00e9ndolas a la apoptosis.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Anomal\u00edas cromos\u00f3micas y p53 en c\u00e1ncer<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Anomal\u00edas cromos\u00f3micas y p53 en c\u00e1ncer <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Arancha Rodr\u00edguez Garc\u00eda <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/09\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Isidro Javier S\u00e1nchez Garc\u00eda<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Lazo zbikonski pedro a. <\/li>\n<li>Javier Benitez (vocal)<\/li>\n<li>Juan  Antonio Bueren roncero (vocal)<\/li>\n<li>cristina Niner pino (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Arancha Rodr\u00edguez Garc\u00eda Si bien se ha descrito que, aproximadamente un 50% de tumores humanos presentan mutaciones\/delecciones [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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