{"id":19025,"date":"2018-03-09T09:07:51","date_gmt":"2018-03-09T09:07:51","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/deteccion-y-distribucion-de-los-peptidos-derivados-del-gen-de-la-drenomedulina-en-hipofisis-de-rana-perezi\/"},"modified":"2018-03-09T09:07:51","modified_gmt":"2018-03-09T09:07:51","slug":"deteccion-y-distribucion-de-los-peptidos-derivados-del-gen-de-la-drenomedulina-en-hipofisis-de-rana-perezi","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/deteccion-y-distribucion-de-los-peptidos-derivados-del-gen-de-la-drenomedulina-en-hipofisis-de-rana-perezi\/","title":{"rendered":"Detecci\u00f3n y distribuci\u00f3n de los p\u00e9ptidos derivados del gen de la drenomedulina en hip\u00f3fisis de rana perezi"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda Collantes Mart\u00ednez <\/strong><\/h2>\n<p>La adrenomedulina (am) y el p\u00e9ptido de 20 amino\u00e1cidos nh2 terminal de la proadrenomedulina (pamp) son dos p\u00e9ptidos reguladores amidados que provienen de un precusor prot\u00e9ico com\u00fan llamado preproadrenomedulina. En mam\u00edferos se ha descrito ya su presencia en m\u00faltiples \u00f3rganos, entre ellos la hip\u00f3fisis, donde parece que contribuyen a la regulaci\u00f3n de la secreci\u00f3n de hormonas por parte de las c\u00e9lulas de la pars distalis. Hasta hoy, los estudios realizados sobre la presencia y funci\u00f3n de la am y el pamp en la hip\u00f3fisis se centran en mam\u00edferos, por lo que el objetivo general de este trabajo ha sido ampliar este conocimiento a un modelo animal de vertebrado no mam\u00edfero (rana perezi).  mediante t\u00e9cnicas inmunocitoqu\u00edmicas se ha encontrado inmunorreactividad para ambos p\u00e9ptidos en la hip\u00f3fisis de rana perezi, mostrando un patr\u00f3n de marcaje diferente. La am se distribuye en algunas c\u00e9lulas endocrinas de la pars distalis y en fibras nerviosas de la zona externa de la eminencia media, pars nervosa y pars intermedia. El pamp se encuentra en gran cantidad de c\u00e9lulas endocrinas de la pars distalis, y de la pars tuberalis. Las diferencias de distribuci\u00f3n y de cantidad de inmunorreactividad entre ambos p\u00e9ptidos permiten creer en la existencia de un mecanismo de expresi\u00f3n diferencial en este \u00f3rgano, tal y como se ha sugerido que ocurre en mam\u00edferos. Mediante an\u00e1lisis de imagen se ha comprobado que los individuos machos poseen en la pars distalis una cantidad de inmunorreactividad para am significativamente mayor que las hembras, mientras que no existen diferencias significativas para el caso del pamp. Los estudios de colocalizaci\u00f3n han permitido establecer qu\u00e9 tipos celulares dentro de la pars distalis se encargan de la producci\u00f3n de ambos p\u00e9ptidos. La am se ha encontrado en c\u00e9lulas de fsh y una subpoblaci\u00f3n de c\u00e9lulas de prl. El pamp colocaliza con c\u00e9lulas de prl, gh y tsh, localiz\u00e1ndose en los gr\u00e1nulos de secreci\u00f3n d<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Detecci\u00f3n y distribuci\u00f3n de los p\u00e9ptidos derivados del gen de la drenomedulina en hip\u00f3fisis de rana perezi<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Detecci\u00f3n y distribuci\u00f3n de los p\u00e9ptidos derivados del gen de la drenomedulina en hip\u00f3fisis de rana perezi <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda Collantes Mart\u00ednez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/09\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda Pilar Sesma Egozcue<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jos\u00e9 Vaquera orte <\/li>\n<li> Villaro gumpert Ana cristina (vocal)<\/li>\n<li>Mar\u00eda  del mar Malagon poyato (vocal)<\/li>\n<li>Luis Montuenga badia (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Collantes Mart\u00ednez La adrenomedulina (am) y el p\u00e9ptido de 20 amino\u00e1cidos nh2 terminal de la proadrenomedulina [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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