{"id":19027,"date":"2018-03-09T09:07:51","date_gmt":"2018-03-09T09:07:51","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/mecanismos-implicados-en-el-efecto-inotropico-positivo-de-los-androgenos-en-la-aura%c2%adcula-izquierda-aislada-de-rata-papel-del-ampc-y-de-las-poliaminas\/"},"modified":"2018-03-09T09:07:51","modified_gmt":"2018-03-09T09:07:51","slug":"mecanismos-implicados-en-el-efecto-inotropico-positivo-de-los-androgenos-en-la-aura%c2%adcula-izquierda-aislada-de-rata-papel-del-ampc-y-de-las-poliaminas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/mecanismos-implicados-en-el-efecto-inotropico-positivo-de-los-androgenos-en-la-aura%c2%adcula-izquierda-aislada-de-rata-papel-del-ampc-y-de-las-poliaminas\/","title":{"rendered":"Mecanismos implicados en el efecto inotr\u00f3pico positivo de los andr\u00f3genos en la aur\u00edcula izquierda aislada de rata: papel del ampc y de las poliaminas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Luc\u00eda Velasco Roces <\/strong><\/h2>\n<p>Los andr\u00f3genos producen un r\u00e1pido efecto intr\u00f3pico positivo en aur\u00edcula aislada de rata a trav\u00e9s de aumentos en el ampc intracelular por interacci\u00f3n en la membrana plasm\u00e1tica. Este efecto precisa la integridad funcional de los receptores beta-adren\u00e9rgicos, sin unirse al receptor, pero parece relacionado con el aumento de poliaminas intracelulares. Estas modulan la funcionalidad de respuestas agudas y la desensibilizaci\u00f3n tras estimulaci\u00f3n de receptores beta1-adren\u00e9rgicos en aur\u00edcula de rata. Adem\u00e1s de respuestas mediadas sobre receptor beta1-adren\u00e9rgicos, las poliaminas interaccionan con receptor beta2-adren\u00e9rgicos, ya que desplazan al radioligando de dicho receptor en membranas de tr\u00e1quea, y modulan respuestas mediadas a trav\u00e9s de dicho receptor. Mecanismos dependientes de la prote\u00edna quinasa a, y postranscripcionales participan en la regulaci\u00f3n actividad ornitina decarboxilasa. estos efectos parecen independientes del receptor andr\u00f3genico intracelular, en base a las caracter\u00edsticas de la respuesta y una farmacolog\u00eda no relacionada con el cl\u00e1sico receptor intracelular.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Mecanismos implicados en el efecto inotr\u00f3pico positivo de los andr\u00f3genos en la aur\u00edcula izquierda aislada de rata: papel del ampc y de las poliaminas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Mecanismos implicados en el efecto inotr\u00f3pico positivo de los andr\u00f3genos en la aur\u00edcula izquierda aislada de rata: papel del ampc y de las poliaminas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Luc\u00eda Velasco Roces <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Oviedo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/09\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel S\u00e1nchez Fern\u00e1ndez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  Luis Tamargo men\u00e9ndez <\/li>\n<li>Mar\u00eda  isabel Cadavid torres (vocal)<\/li>\n<li>Manuel Vijande v\u00e1zquez (vocal)<\/li>\n<li>Jos\u00e9 Manuel Rubin lopez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Luc\u00eda Velasco Roces Los andr\u00f3genos producen un r\u00e1pido efecto intr\u00f3pico positivo en aur\u00edcula aislada de rata a [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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