{"id":19036,"date":"2018-03-09T09:07:52","date_gmt":"2018-03-09T09:07:52","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/actividad-in-vitro-de-oxaliplatino-asociado-a-otros-farmacos-y-demostracion-de-la-revision-de-la-resistencia-a-5-fluorouracilo\/"},"modified":"2018-03-09T09:07:52","modified_gmt":"2018-03-09T09:07:52","slug":"actividad-in-vitro-de-oxaliplatino-asociado-a-otros-farmacos-y-demostracion-de-la-revision-de-la-resistencia-a-5-fluorouracilo","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/actividad-in-vitro-de-oxaliplatino-asociado-a-otros-farmacos-y-demostracion-de-la-revision-de-la-resistencia-a-5-fluorouracilo\/","title":{"rendered":"Actividad in vitro de oxaliplatino asociado a otros f\u00e1rmacos y demostraci\u00f3n de la revisi\u00f3n de la resistencia a 5-fluorouracilo"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Carmen Plasencia Castillo <\/strong><\/h2>\n<p>Uno de los principales obst\u00e1culos en el tratamiento del c\u00e1ncer colorrectal (crc) es la resistencia a quimioterapia. El 5-fluorouracilo (5-fu) inhibidor de la enzima timidilato sintasa (ts), contin\u00faa siendo la terapia de est\u00e1ndar en este tipo de tumores. La sobreexpresi\u00f3n del gen ts correlaciona cl\u00ednicamente con la resitencia a 5-fu. En nuestro estudio se generaron dos l\u00edneas con resistencia a 5-fu (ht29-5fur y lovo-5fur) por exposici\u00f3n continuada a dosis creciente del f\u00e1rmaco. Las l\u00edneas resistentes presentaron un patr\u00f3n del ciclo celular, tiempos de duplicaci\u00f3n comparables a los de sus hom\u00f3logas sensibles (ht29 y lovo, respectivamente) y mostraron entre 5 y 3 veces m\u00e1s resistencia a 5-fu. No se hallaron diferencias en la sensibilidad de estas l\u00edneas al oxaliplatino. En cambio, la l\u00ednea lovo-5fur mostr\u00f3 un patr\u00f3n de resistencia cruzada a inhibidores de la topoisomerasas i (tpt, c pt-11 y sn38). La adaptaci\u00f3n de las l\u00edneas al 5-fu no alter\u00f3 el estado de la p53 ni el fenotipo de errores de replicaci\u00f3n (rer). El fenotipo de resistencia a 5-fu observado correlacion\u00f3 con la sobreexpresi\u00f3n de ts aunque no se observ\u00f3 un proceso de amplificaci\u00f3n g\u00e9nica. El an\u00e1lisis fen\u00f3mico comparativo (cgh) mostr\u00f3 la existencia de anormalidades gen\u00e9ticas (ganancias\/p\u00e9rdudas) en las l\u00edneas resistentes a 5-fu comparadas a sus respectivas hom\u00f3logas sensibles que podr\u00edan estar potencialmente implicadas en la adquisici\u00f3n de la resistencia a 5-fu.  el oxaliplatino (oxa) y los inhibidores de topoisomerasa i son agentes citot\u00f3xicos con actividad antitumoral en el ccr. En el presente estudio, analizamos la citotoxicidad de las asociaciones de oxa y 5-fu o tpt en un panel de l\u00edneas celulares derivadas de tumores colorrectales sensibles (ht29, lovo, dld-1 y ls-513) y resistentes a 5-fu (ht29-5fur y lovo-5fur). asimismo se analiz\u00f3 la expresi\u00f3n de ts (arnm y prote\u00edna) y topoisomerasa i (topo i; arnm) tras la exposici\u00f3n a oxa como par<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Actividad in vitro de oxaliplatino asociado a otros f\u00e1rmacos y demostraci\u00f3n de la revisi\u00f3n de la resistencia a 5-fluorouracilo<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Actividad in vitro de oxaliplatino asociado a otros f\u00e1rmacos y demostraci\u00f3n de la revisi\u00f3n de la resistencia a 5-fluorouracilo <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Carmen Plasencia Castillo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/09\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Albert Abad Esteve<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: alfredo Carrato mena <\/li>\n<li>agust\u00ed Barnadas molins (vocal)<\/li>\n<li>joan Costa pag\u00e9s (vocal)<\/li>\n<li>xavier Mayol  girbau (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carmen Plasencia Castillo Uno de los principales obst\u00e1culos en el tratamiento del c\u00e1ncer colorrectal (crc) es la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[160,155,9,189,484,347,17,457,3369],"tags":[44049,58686,12099,58685,58687,37454],"class_list":["post-19036","post","type-post","status-publish","format-standard","hentry","category-bioquimica","category-ciencias-clinicas","category-ciencias-medicas","category-farmacodinamia","category-mecanismos-de-accion-de-la-quimioterapia","category-oncologia-clinica","category-quimica","category-quimica-farmaceutica","category-quimioterapia","tag-agusti-barnadas-molins","tag-albert-abad-esteve","tag-alfredo-carrato-mena","tag-carmen-plasencia-castillo","tag-joan-costa-pages","tag-xavier-mayol-girbau"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/19036","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=19036"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/19036\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=19036"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=19036"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=19036"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}