{"id":19175,"date":"2018-03-09T09:08:04","date_gmt":"2018-03-09T09:08:04","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudios-de-reacciones-de-sustitucion-electrofilica-en-24-dihidro-1h-pirazino-21-bquinazolina-36-dionas\/"},"modified":"2018-03-09T09:08:04","modified_gmt":"2018-03-09T09:08:04","slug":"estudios-de-reacciones-de-sustitucion-electrofilica-en-24-dihidro-1h-pirazino-21-bquinazolina-36-dionas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/estudios-de-reacciones-de-sustitucion-electrofilica-en-24-dihidro-1h-pirazino-21-bquinazolina-36-dionas\/","title":{"rendered":"Estudios de reacciones de sustituci\u00f3n electrofilica en 2,4-dihidro-1h-pirazino (2,1-b)quinazolina-3,6-dionas"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Buenadicha Loarte F\u00e9lix L. <\/strong><\/h2>\n<p>En la presente tesis doctoral se han sintetizado los sistemas de 2-bencil-2,4-dihidro-1h-pirazino(2,1-b)quinazolina-3,6dionas 1 \u00f3 4 sustituidas y se ha estudiado su comportamiento frente a diversas reacciones de sustituci\u00f3n electrofilica, especialmente frente a reacciones de alquilaci\u00f3n. Los resultados obtenidos se han aprovechado para la sintesis de los productos naturales fumiquinazolina f y fiscalina b. Tambi\u00e9n se han realizado estudios estructura-actividad por su acci\u00f3n anti-mdr de los derivados obtenidos, concluyendose que el sistema triciclico mencionado es parte fundamental para la actividad biol\u00f3gica del inhibidor mdr ardeemina.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudios de reacciones de sustituci\u00f3n electrofilica en 2,4-dihidro-1h-pirazino (2,1-b)quinazolina-3,6-dionas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudios de reacciones de sustituci\u00f3n electrofilica en 2,4-dihidro-1h-pirazino (2,1-b)quinazolina-3,6-dionas <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Buenadicha Loarte F\u00e9lix L. <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 26\/09\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Sollhuber Kretzer M\u00f3nica M.<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: benito Alcaide ala\u00f1on <\/li>\n<li> Garc\u00eda l\u00f3pez Mar\u00eda  teresa (vocal)<\/li>\n<li>Antonio Monge vega (vocal)<\/li>\n<li>angel Gutierrez ravelo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Buenadicha Loarte F\u00e9lix L. En la presente tesis doctoral se han sintetizado los sistemas de 2-bencil-2,4-dihidro-1h-pirazino(2,1-b)quinazolina-3,6dionas 1 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[17,457,416],"tags":[9716,7150,5891,59037,59039,59038],"class_list":["post-19175","post","type-post","status-publish","format-standard","hentry","category-quimica","category-quimica-farmaceutica","category-quimica-organica","tag-angel-gutierrez-ravelo","tag-antonio-monge-vega","tag-benito-alcaide-alanon","tag-buenadicha-loarte-felix-l","tag-garcia-lopez-maria-teresa","tag-sollhuber-kretzer-monica-m"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/19175","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=19175"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/19175\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=19175"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=19175"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=19175"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}