{"id":19220,"date":"2018-03-09T09:08:08","date_gmt":"2018-03-09T09:08:08","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/perfil-cinetico-de-la-suxibuzona-para-su-uso-en-la-cla%c2%adnica-de-equidos\/"},"modified":"2018-03-09T09:08:08","modified_gmt":"2018-03-09T09:08:08","slug":"perfil-cinetico-de-la-suxibuzona-para-su-uso-en-la-cla%c2%adnica-de-equidos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/perfil-cinetico-de-la-suxibuzona-para-su-uso-en-la-cla%c2%adnica-de-equidos\/","title":{"rendered":"Perfil cin\u00e9tico de la suxibuzona para su uso en la cl\u00ednica de \u00e9quidos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Irene May\u00f3s Servet <\/strong><\/h2>\n<p>La suxibuzona es un antiinflamatorio no esteroideo utilizado en la cl\u00ednica equina. Qu\u00edmicamente se define como \u00e9ster de la fenilbutazona. Ambas mol\u00e9culas est\u00e1n estrechamente relacionadas debido a que la suxibuzona se metaboliza r\u00e1pidamente a fenilbutazona, ya sea al administrarla por v\u00eda oral como por v\u00eda intravenosa en el caballo.  el objetivo del presente estudio es el de evaluar la relaci\u00f3n del perfil de disponibilidad de la administraci\u00f3n de la fenilbutazona y de su principal metabolito la oxifenbutazona tras la administraci\u00f3n de la suxibuzona o de fenilbutazona a dosis equimoleculares, tanto en caballos en ayunas como en animales que siguen su dieta habitual. Asimismo se ha estudiado la disponibilidad de estas mol\u00e9culas en el l\u00edquido sinovial evaluando su capacidad para desarrollar su efecto antiinflamatorio en las articulaciones.  en una primera fase experimental se administraron a 19 caballos, siguiendo un dise\u00f1o cruzado, 6.25 mg\/kg de suxibuzona (a) y 4.4 mg\/kg de fenilbutazona (b) por v\u00eda oral en ayunas. La disponibilidad relativa respecto a las concentraciones de fenilbutazona fue de de 0.82+-0.16 y para la oxifenbutazona de 0.85+-0.26. la semivida de eliminaci\u00f3n de la fenilbutazona fue de 7h aprox. El tmax (h) para la fenilbutazona fue de 4.9+-3.1 (a), 3.2+-2.7 (b) y cmax (ug\/ml) 10.2+-2.2 (a), 15.5 +- 3.6 (b).  tras el an\u00e1lisis del l\u00edquido sinovial (n=6) se obtuvieron los siguientes resultados a las 6h: 2.3+-1.4 (pbz), 0.4+-0.2 (opbz); a las 12h: 2.6+-0.7 (pbz), 0.7+-0.3 (opbz) y a 24h: 1.0+-0.3 (pbz), 0.7+-0.2 (opbz).  en una segunda fase experimental se administraron las mismas dosis de suxibuzona (c) y fenilbutazona (d), incorporadas en su dieta habitual, a 10 animales (5 por tratamiento). La disponibilidad relativa entre la administraci\u00f3n en el alimento frente a ayunas fue f c\/a 0.76+-0.18 y f d\/b 0.65+-0.16 para la fenilbutazona, y f c\/a 0.74+-0.20 y f d\/b 0.75+-0.17 la oxifenbutazona. el tmax (h) pa<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Perfil cin\u00e9tico de la suxibuzona para su uso en la cl\u00ednica de \u00e9quidos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Perfil cin\u00e9tico de la suxibuzona para su uso en la cl\u00ednica de \u00e9quidos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Irene May\u00f3s Servet <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 27\/09\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Margarida Arboi Arzo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: llu\u00eds Monreal bosch <\/li>\n<li>helena Colom (vocal)<\/li>\n<li> San Andr\u00e9s larrea Manuel (vocal)<\/li>\n<li>victoria Jaraiz m. (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Irene May\u00f3s Servet La suxibuzona es un antiinflamatorio no esteroideo utilizado en la cl\u00ednica equina. Qu\u00edmicamente se [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[494,9,515,20755,2445,957,5675,1946],"tags":[59151,59149,52623,59150,41057,59152],"class_list":["post-19220","post","type-post","status-publish","format-standard","hentry","category-ciencias-agrarias","category-ciencias-medicas","category-ciencias-veterinarias","category-equinos","category-evaluacion-de-farmacos","category-farmacologia","category-farmacologia-veterinaria","category-produccion-animal","tag-helena-colom","tag-irene-mayos-servet","tag-lluis-monreal-bosch","tag-margarida-arboi-arzo","tag-san-andres-larrea-manuel","tag-victoria-jaraiz-m"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/19220","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=19220"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/19220\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=19220"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=19220"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=19220"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}