{"id":19235,"date":"2018-03-09T09:08:09","date_gmt":"2018-03-09T09:08:09","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/alteraciones-del-sistema-colinergico-en-ratas-con-hipofuncion-colinergica-y-en-la-enfermedad-de-alzheimer\/"},"modified":"2018-03-09T09:08:09","modified_gmt":"2018-03-09T09:08:09","slug":"alteraciones-del-sistema-colinergico-en-ratas-con-hipofuncion-colinergica-y-en-la-enfermedad-de-alzheimer","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/alteraciones-del-sistema-colinergico-en-ratas-con-hipofuncion-colinergica-y-en-la-enfermedad-de-alzheimer\/","title":{"rendered":"Alteraciones del sistema colin\u00e9rgico en ratas con hipofunci\u00f3n colin\u00e9rgica y en la enfermedad de alzheimer"},"content":{"rendered":"<h2>Tesis doctoral de <strong> M\u00f3nica Garc\u00eda Alloza <\/strong><\/h2>\n<p>Adem\u00e1s de la implicaci\u00f3n del sistema colin\u00e9rgico en la enfermedad de alzheimer (ea) numerosos estudios han mostrado la relevancia del sistema seroton\u00e9rgico en los trastornos \u00abno cognitivos\u00bb asociados a la ea, as\u00ed como en la modulaci\u00f3n del sistema colin\u00e9rgico. Por todo ello nos pareci\u00f3 relevante estudiar las alteraciones del sistema seroton\u00e9rgico en situaciones de hipofunci\u00f3n del sistema colin\u00e9rgico, as\u00ed como las posibles repercusiones funcionales derivadas. Para ello realizamos un estudio en animales de experimentaci\u00f3n y un estudio posmortem en tejido cerebral humano procedente de enfermos de alzheimer.  estudiamos el efecto de una lesi\u00f3n con 192 igg-saporina de los n\u00facleos basales de meynert (nbm) en ratas tanto a corto como a largo plazo. Observamos una reducci\u00f3n significativa de los par\u00e1metros colin\u00e9rgicos en los nbm y en su \u00e1rea de proyecci\u00f3n, la corteza frontal. Los niveles de acetilcolina y 5-ht corticales se redujeron significativamente tras la lesi\u00f3n. Dado que la 5-ht ejerce un efecto inhibitorio sobre la liberaci\u00f3n de acetilcolina cortical, la disminuci\u00f3n de los niveles de 5-ht podr\u00eda suponer un intento del sistema seroton\u00e9rgico de compensar la p\u00e9rdida de funcionalidad colin\u00e9rgica. en el mecanismo responsable de esta modulaci\u00f3n parece excluirse la participaci\u00f3n de los receptores 5-ht1a o 5-ht1b. La segunda parte del trabajo se realiz\u00f3 en tejido cortical humano posmortem (\u00e1reas 10 y 20 de broadmann) procedente de pacientes con ea. Observamos una profunda denervaci\u00f3n colin\u00e9rgica cortical que se correlacion\u00f3 con los trastornos cognitivos premortem de los pacientes, corroborando la implicaci\u00f3n colinergica a este nivel. Por otro lado, se observ\u00f3 una disminuci\u00f3n en marcadores seroton\u00e9rgicos corticales que se correlacion\u00f3 significativamente con los \u00abtrastornos no cognitivos\u00bb asociados a la enfermedad. En este sentido el receptor 5-ht6 parece especialmente relevante en trastornos como hiperactividad<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Alteraciones del sistema colin\u00e9rgico en ratas con hipofunci\u00f3n colin\u00e9rgica y en la enfermedad de alzheimer<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Alteraciones del sistema colin\u00e9rgico en ratas con hipofunci\u00f3n colin\u00e9rgica y en la enfermedad de alzheimer <\/li>\n<li><strong>Autor:<\/strong>\u00a0 M\u00f3nica Garc\u00eda Alloza <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 27\/09\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda  Javier Ramirez Gil<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: edurne Cenarruzabeitia sagarminaga <\/li>\n<li>ram\u00f3n Trullas oliva (vocal)<\/li>\n<li>Jos\u00e9 Rodrigo garcia (vocal)<\/li>\n<li>norberto Aguirre garcia (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de M\u00f3nica Garc\u00eda Alloza Adem\u00e1s de la implicaci\u00f3n del sistema colin\u00e9rgico en la enfermedad de alzheimer (ea) numerosos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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