{"id":19316,"date":"2002-02-10T00:00:00","date_gmt":"2002-02-10T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/interacciones-farmacologicas-entre-la-34-metilenodioximetanfetamina-mdma-extasis-y-el-alcohol-administrados-a-dosis-unicas-en-humanos\/"},"modified":"2002-02-10T00:00:00","modified_gmt":"2002-02-10T00:00:00","slug":"interacciones-farmacologicas-entre-la-34-metilenodioximetanfetamina-mdma-extasis-y-el-alcohol-administrados-a-dosis-unicas-en-humanos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/interacciones-farmacologicas-entre-la-34-metilenodioximetanfetamina-mdma-extasis-y-el-alcohol-administrados-a-dosis-unicas-en-humanos\/","title":{"rendered":"Interacciones farmacol\u00f3gicas entre la 3,4-metilenodioximetanfetamina (mdma, \u00e9xtasis) y el alcohol administrados a dosis \u00fanicas en humanos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Candido Hern\u00e1ndez Lopez <\/strong><\/h2>\n<p>El policonsumo  es el patr\u00f3n de uso de drogas m\u00e1s frecuente. En el policonsumo asociado a la mdma (\u00e9xtasis), la combinaci\u00f3n suele ser con tabaco, cannabis o alcohol. Con anterioridad a esta memoria no exist\u00edan estudios experimentales en humanos que hubieran evaluado la administraci\u00f3n combinada de mdma y alcohol. El objetivo de la presente memoria fue estudiar los efectos en humanos del consumo simult\u00e1neo, en condicines controladas, de una dosis \u00fanica de mdma similar a la empleada con fines recreacionales y una dosis e alcohol capaz de producir una intoxicaci\u00f3n et\u00c2\u00bflica.  se realiz\u00f3 un ensayo cl\u00ednico con nueve voluntarios varones y sanos con experiencia en el consumo de \u00e9xtasis y alcohol. El dise\u00f1o del estudio fue doble ciego y con doble enmascaramiento, cruzado, controlado con placebo y con asignaci\u00f3n aleatoria. Las cuatro condiciones de tratamiento consistieron en la administraci\u00f3n oral de 100 mg de mdam, de alcohol (vodka) a una dosis ajustada por peso de 0,8 g\/kg, la combinaci\u00f3n de mdam y alcohol a las dosis referidas, y el placebo de ambos. Estas dosis se seleccionaron a partir de los resultados de estudios pilotos.  se evaluaron par\u00e1metros farmacodin\u00e1micos, de seguridad y farmacocin\u00e9ticos, incluyendo constantes vitales, rendimiento psicomotor, efectos subjetivos y niveles hormonales. Las drogas administradas y los metabolitos m\u00e1s importantes de la mdma fueron analizados en plasma. Los valores se analizaron coom diferencias a la basal, calculando posteriormente el \u00e1rea bajo la curva (auc) y el efecto (emax) o la concentraci\u00f3n m\u00e1xima (cmax) dependiendo del tipo de variable. Abmas estimaciones fueron sometidas a un an\u00e1lisis de la varianza (anova).  la administraci\u00f3n de una dosis \u00fanica de 100 mg de mdma produjo los efectos ya descritos, y que inclu\u00edan un aumento considerable de la presi\u00f3n arterial y la frecuencia cardiaca, midriasis, ligera elevaci\u00f3n de la temperatura oral y esoforia. Hubo una sensaci\u00f3n de<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Interacciones farmacol\u00f3gicas entre la 3,4-metilenodioximetanfetamina (mdma, \u00e9xtasis) y el alcohol administrados a dosis \u00fanicas en humanos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Interacciones farmacol\u00f3gicas entre la 3,4-metilenodioximetanfetamina (mdma, \u00e9xtasis) y el alcohol administrados a dosis \u00fanicas en humanos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Candido Hern\u00e1ndez Lopez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 02\/10\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mag\u00ed Farr\u00e9 Albaladejo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jordi Cami morell <\/li>\n<li>Marta Torrens melich (vocal)<\/li>\n<li>Juan Gutierrez cebollada (vocal)<\/li>\n<li>ramon Miralles basseda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Candido Hern\u00e1ndez Lopez El policonsumo es el patr\u00f3n de uso de drogas m\u00e1s frecuente. En el policonsumo [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[59400,13665,59401,13915,33924,59402],"class_list":["post-19316","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-candido-hernandez-lopez","tag-jordi-cami-morell","tag-juan-gutierrez-cebollada","tag-magi-farre-albaladejo","tag-marta-torrens-melich","tag-ramon-miralles-basseda"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/19316","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=19316"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/19316\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=19316"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=19316"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=19316"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}