{"id":19317,"date":"2002-02-10T00:00:00","date_gmt":"2002-02-10T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-pesticidas-organofosforados-sobre-la-proliferacion-y-transformacion-de-celulas-de-glandula-mamaria\/"},"modified":"2002-02-10T00:00:00","modified_gmt":"2002-02-10T00:00:00","slug":"efecto-de-pesticidas-organofosforados-sobre-la-proliferacion-y-transformacion-de-celulas-de-glandula-mamaria","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-pesticidas-organofosforados-sobre-la-proliferacion-y-transformacion-de-celulas-de-glandula-mamaria\/","title":{"rendered":"Efecto de pesticidas organofosforados sobre la proliferaci\u00f3n y transformaci\u00f3n de c\u00e9lulas de gl\u00e1ndula mamaria"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Gertrudis Cabello Fern\u00e1ndez <\/strong><\/h2>\n<p>En este trabajo se ha estudiado el efecto de los insecticidas organofosforados (iofs), parati\u00f3n y malati\u00f3n, sobre la proliferaci\u00f3n y posible transformaci\u00f3n de c\u00e9lulas de la gl\u00e1ndula mamaria. Estos compuestos son de amplio uso dom\u00e9stico contra par\u00e1sitos, y en agricultura se utilizan para el control de plagas. parati\u00f3n y malati\u00f3n act\u00faan inhibiendo la acetilcolinesterasa (ace) y tambi\u00e9n ocupando los receptores colin\u00e9rgicos muscar\u00ednicos.  los resultados obtenidos muestran que en ratas sprague-dawley tratadas durante cinco d\u00edas con concentraciones de parati\u00f3n (250 ug\/100g p.C.) Y malati\u00f3n (17 mg\/100 g p.C.) Que no alteran la viabilidad de los animales, no afectan al desarrollo de la gl\u00e1ndula mamaria en animales de 21 d\u00edas de edad. Sin embargo, estos mismos tratamientos bloquean el proceso normal de diferenciaci\u00f3n de brotes terminales (bts) a alveolares (bas), en ratas de 44 d\u00edas de edad. Adem\u00e1s, se observa que en los 28 meses posteriores al tratamiento de animales de 44 d\u00edas de edad aparecen lesiones tumorales en la gl\u00e1ndula mamaria, en un porcentaje que var\u00eda entre el 8% y el 24%, no observ\u00e1ndose alteraciones en animales controles. La naturaleza de las lesiones mamarias se ha analizado mediante observaci\u00f3n histol\u00f3gica e inmunohistoqu\u00edmica, encontr\u00e1ndose que la mayor\u00eda de las mismas son hiperplasias, adenomas y fibroadenomas. No obstante, cuatro de las tumoraciones, tres inducidas por malati\u00f3n y una por parati\u00f3n, mostraron un resultado diagn\u00f3stico correspondiente a carcinomas. Los resultados obtenidos con malati\u00f3n y parati\u00f3n con mimetizados por tratamiento con aserina, inhibidor de la ace, pero se previenen con tratamientos combinados de pesticidas y antropina (antagonista espec\u00edfico de la acetilcolina en el receptor muscar\u00ednico). Los estudios in vivo, se han complementado con estudios in vitro en la l\u00ednea celular mcf-7, donde se observa que tanto el parati\u00f3n como el malati\u00f3n, provocan un aumento de la p<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto de pesticidas organofosforados sobre la proliferaci\u00f3n y transformaci\u00f3n de c\u00e9lulas de gl\u00e1ndula mamaria<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto de pesticidas organofosforados sobre la proliferaci\u00f3n y transformaci\u00f3n de c\u00e9lulas de gl\u00e1ndula mamaria <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Gertrudis Cabello Fern\u00e1ndez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 02\/10\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda \u00e1ngeles Juarranz De La Fuente<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Gosalvez berenguer Jos\u00e9 Jaime <\/li>\n<li>carmelo Bernabeu quirante (vocal)<\/li>\n<li>Juan  Carlos Stockert cossu (vocal)<\/li>\n<li> Ram\u00edrez Garc\u00eda Jos\u00e9 ram\u00f3n (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gertrudis Cabello Fern\u00e1ndez En este trabajo se ha estudiado el efecto de los insecticidas organofosforados (iofs), parati\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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