{"id":19389,"date":"2002-08-10T00:00:00","date_gmt":"2002-08-10T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/transmision-y-analisis-temporal-de-senales-periodicas-en-rutas-metabolicas\/"},"modified":"2002-08-10T00:00:00","modified_gmt":"2002-08-10T00:00:00","slug":"transmision-y-analisis-temporal-de-senales-periodicas-en-rutas-metabolicas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/transmision-y-analisis-temporal-de-senales-periodicas-en-rutas-metabolicas\/","title":{"rendered":"Transmisi\u00f3n y an\u00e1lisis temporal de se\u00f1ales peri\u00f3dicas en rutas metab\u00f3licas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Yoel Rodr\u00edguez Fern\u00e1ndez <\/strong><\/h2>\n<p>Se estudia, desde un punto de vista te\u00f3rico, la transmisi\u00f3n de oscilaciones de concentraci\u00f3n de metabolitos a trav\u00e9s de rutas metab\u00f3licas con cin\u00e9ticas tipo michaelis-menten. En una primera aproximaci\u00f3n se examinan los sistemas secuenciales y ramificados que convergen a un punto con din\u00e1micas lineales. de aqu\u00ed resultan expresiones anal\u00edticas de la relaci\u00f3n entre las amplitudes de salida y entrada (amortiguamiento) y de los desfases de las velocidades de cada peso de reacci\u00f3n con el flujo de entrada y entre s\u00ed.  se muestra que a efectos de la transmisi\u00f3n de se\u00f1ales sinusoidales las enzimas michaelianas presentan aproximadamente un comportamiento lineal alrededor del fujo medio de entrada, con independencia de la amplitud de la onda.  por ello, es posible predecir las propiedades de dicha transmisi\u00f3n a partir de sus correspondientes sistemas lineales siempre que se conozcan las constantes de velocidad de primer orden efectivas.  de la misma forma, se ha demostrado que los sistemas ramificados enzim\u00e1ticos con enzimas cin\u00e9ticamente diferentes (a efectos de la transmisi\u00f3n de las se\u00f1ales sinuosidales) se pueden reducir a rutas secuenciales para un conjunto dado de actividades enzim\u00e1ticas.  adem\u00e1s, se ha concluido que las enzimas que mejor transmitir\u00e1n una se\u00f1al oscilatoria sinusoidal, ser\u00e1n aquellas que trabajen a baja saturaci\u00f3n e irreversiblemente.  por otra parte, con el objetivo de caracterizar temporalmente a los sistemas biol\u00f3gicos, se ha propuesto la definici\u00f3n de una magnitud llamada tiempo caracter\u00edstico, tc, que permiten el c\u00e1lculo del tiempo promedio que tardan las transiciones que involucran din\u00e1micas tipo nodo, foco y ciclo l\u00edmite estables.  asimismo, a partir de esta nueva magnitud (tc) se introduce una variable promedio que mide el tiempo que tardan las transiciones que impliquen, en el estado inicial o final o ambos, comportamientos oscilatorios.  finalmente, se ha propuesto un m\u00e9todo de<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Transmisi\u00f3n y an\u00e1lisis temporal de se\u00f1ales peri\u00f3dicas en rutas metab\u00f3licas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Transmisi\u00f3n y an\u00e1lisis temporal de se\u00f1ales peri\u00f3dicas en rutas metab\u00f3licas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Yoel Rodr\u00edguez Fern\u00e1ndez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 08\/10\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Montero Carnerero<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: federico Mor\u00e1n abad <\/li>\n<li>Carlos Sanz mu\u00f1o (vocal)<\/li>\n<li>enrique Melendez hevia (vocal)<\/li>\n<li>enric Canela campos (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Yoel Rodr\u00edguez Fern\u00e1ndez Se estudia, desde un punto de vista te\u00f3rico, la transmisi\u00f3n de oscilaciones de concentraci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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