{"id":19393,"date":"2002-08-10T00:00:00","date_gmt":"2002-08-10T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/neuroanatoma%c2%ada-funcional-de-la-va%c2%ada-trigeminal-peptidergica-papel-de-los-neuropeptidos-y-su-relacion-con-el-dolor-de-cabeza\/"},"modified":"2002-08-10T00:00:00","modified_gmt":"2002-08-10T00:00:00","slug":"neuroanatoma%c2%ada-funcional-de-la-va%c2%ada-trigeminal-peptidergica-papel-de-los-neuropeptidos-y-su-relacion-con-el-dolor-de-cabeza","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/salamanca\/neuroanatoma%c2%ada-funcional-de-la-va%c2%ada-trigeminal-peptidergica-papel-de-los-neuropeptidos-y-su-relacion-con-el-dolor-de-cabeza\/","title":{"rendered":"Neuroanatom\u00edafuncional de la v\u00edatrigeminal peptid\u00e9rgica. papel de los neurop\u00e9ptidos y su relaci\u00f3n con el dolor de cabeza"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mohtashem Samsam <\/strong><\/h2>\n<p>La duramadre est\u00e1 principalmente inervada por las terminaciones del trig\u00e9mino (sistema trig\u00e9minovascular). Tanto la duramadre como las terminaciones del trig\u00e9mino intervienen en el dolor de cabeza. El ganglio del trig\u00e9mino contiene neuronas sensoriales primarias que poseen neurop\u00e9ptidos, entre otros, el p\u00e9ptido relacionado con el gen de la calcitonina (cgrp), la sustancia p (sp) y la neuroquinina a (nka). Estos neurop\u00e9ptidos aumentaron en la sangre durante los ataques de migra\u00f1a. La inflamaci\u00f3n neurog\u00e9nica en el sistema trig\u00e9minovascular ha sido propuesta como responsable de las alteraciones que se producen en las cefal\u00e9as vasculares, incluida la migra\u00f1a. La estimulaci\u00f3n el\u00e9ctrica del ganglio del trig\u00e9mino produce inflamaci\u00f3n neurog\u00e9nica en la duramadre debido a la liberaci\u00f3n de los neurop\u00e9ptidos.  hemos estimulado el\u00e9ctricamente el ganglio del trig\u00e9mino para inducir dicha inflamaci\u00f3n en la duramadre y as\u00ed trabajar en un modelo experimental de dolor semejante al que se produce durante la cefal\u00e9a.  la estimulaci\u00f3n el\u00e9ctrica del ganglio del trig\u00e9mino produjo la liberaci\u00f3n de cgrp, nka, sp, somatostatina, neurotensina y metionina-encefalina a partir de las terminaciones ipsilaterales centrales trigeminales del n\u00facleo caudal del trig\u00e9mino (nct) de la rata. La liberaci\u00f3n de los mencionados neurop\u00e9ptidos en dicho n\u00facleo activar\u00eda a las neuronas del nct que transmitir\u00edan la informaci\u00f3n dolorosa hacia centros superiores. Adem\u00e1s, observamos al mismo tiempo la coliberaci\u00f3n de cgrp, sp y nka en el lado ipsilateral del nct.  esta observaci\u00f3n indica que los tres neurop\u00e9ptidos cooperan en la nocicepci\u00f3n.  la sp, as\u00ed como el glutamato, podr\u00edan activar a las neuronas secundarias en el nct y el cgrp inhibir la degradaci\u00f3n de la sp. Adem\u00e1s, observamos una liberaci\u00f3n de los neurop\u00e9ptidos cgrp, sp y nka no s\u00f3lo en el lado ipsilateral, sino tambi\u00e9n en el lado contralateral, tras estimular unilateralmente el<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Neuroanatom\u00edafuncional de la v\u00edatrigeminal peptid\u00e9rgica. papel de los neurop\u00e9ptidos y su relaci\u00f3n con el dolor de cabeza<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Neuroanatom\u00edafuncional de la v\u00edatrigeminal peptid\u00e9rgica. papel de los neurop\u00e9ptidos y su relaci\u00f3n con el dolor de cabeza <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mohtashem Samsam <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 08\/10\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rafael Cove\u00f1as Rodr\u00edguez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Miguel angel Merchan cifuentes <\/li>\n<li>pedro Pesini ruiz (vocal)<\/li>\n<li>rosario P\u00e1saro dionisio (vocal)<\/li>\n<li> Narv\u00e1ez bueno Jos\u00e9 angel (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mohtashem Samsam La duramadre est\u00e1 principalmente inervada por las terminaciones del trig\u00e9mino (sistema trig\u00e9minovascular). Tanto la duramadre [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9386],"tags":[9729,59586,7922,55140,9728,10939],"class_list":["post-19393","post","type-post","status-publish","format-standard","hentry","category-salamanca","tag-miguel-angel-merchan-cifuentes","tag-mohtashem-samsam","tag-narvaez-bueno-jose-angel","tag-pedro-pesini-ruiz","tag-rafael-covenas-rodriguez","tag-rosario-pasaro-dionisio"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/19393","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=19393"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/19393\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=19393"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=19393"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=19393"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}