{"id":19467,"date":"2018-03-09T09:08:27","date_gmt":"2018-03-09T09:08:27","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/mecanismos-implicados-en-la-neurotoxicidad-mediada-por-mpp-en-celulas-granulares-de-cerebelo-mecanismos-de-neuroproteccion\/"},"modified":"2018-03-09T09:08:27","modified_gmt":"2018-03-09T09:08:27","slug":"mecanismos-implicados-en-la-neurotoxicidad-mediada-por-mpp-en-celulas-granulares-de-cerebelo-mecanismos-de-neuroproteccion","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/mecanismos-implicados-en-la-neurotoxicidad-mediada-por-mpp-en-celulas-granulares-de-cerebelo-mecanismos-de-neuroproteccion\/","title":{"rendered":"Mecanismos implicados en la neurotoxicidad mediada por mpp+ en c\u00e9lulas granulares de cerebelo. mecanismos de neuroprotecci\u00f3n"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Rosa Ana Gonz\u00e1lez Polo <\/strong><\/h2>\n<p>Los objetivos que se plantearon para la realizaci\u00f3n de esta tesis doctoral fueron los siguientes:  1,- establecer un protocolo definido de la muerte celular por apoptosis inducida por mpp + en cgcs.  2,- estudiar los cambios metab\u00f3licos que se producen en las cgcs tratadas con mpp+.  3,- determinar la producci\u00f3n y precisar el papel de las especies reactivas en la muerte celular inducida por mpp+ en cgcs.  4,- determinar los mecanismos moleculares que tienen lugar en la muerte celular por apoptosis inducida por mpp+, y la posible implicaci\u00f3n de diferentes prote\u00ednas anti y pro-apopt\u00f3ticas.  5,- estudiar los efectos neuroprotectores que diversos antioxidantes y, especialmente la vitamina e, ejercen sobre la muerte neuronal inducida por mpp+.  las conclusiones a las que llegamos fueron:  1,- mpp+ produce en las cgcs un modelo de muerte celular cuyos mecanismos moleculares son compatibles con un modelo aopot\u00f3tico.  2,- mpp+ provoca en las cgcs cambios metab\u00f3licos, como depleci\u00f3n de nad+, disminuci\u00f3n de los niveles de atp, y acumulaci\u00f3n de lactato.  3,- mpp+ induce la formaci\u00f3n de diversas especies reactivas. La incubaci\u00f3n con diversos inhibidores de la nos y agentes antioxidantes, en especial la vitamina e, incrementa notablemente los valores de supervivencia celular.  4,- la generaci\u00f3n temprana de ros supone un paso esencial en la se\u00f1alizaci\u00f3n intracelular de la apoptosis inducida por mpp+ en cgcs.  5,- mpp+ induce, de una manera temprana, la traslocaci\u00f3n de bax desde el citoplasma a la mitocondria, defosforilaci\u00f3n de bad, salida de citocromo c desde la mitocondria al citosol y activaci\u00f3n de caspasa 3. Todos estos fen\u00f3menos son bloqueados por la presencia de vitamina e.  6,- otros bipiridinios de inter\u00e9s agroambiental, como el paraquat, producen neurotoxicidad siguiendo un modelo, en principio, similar al del mpp+.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Mecanismos implicados en la neurotoxicidad mediada por mpp+ en c\u00e9lulas granulares de cerebelo. mecanismos de neuroprotecci\u00f3n<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Mecanismos implicados en la neurotoxicidad mediada por mpp+ en c\u00e9lulas granulares de cerebelo. mecanismos de neuroprotecci\u00f3n <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Rosa Ana Gonz\u00e1lez Polo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Extremadura<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 14\/10\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Fuentes Rodr\u00edguez Jos\u00e9 Manuel<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Carlos Guti\u00e9rrez merino <\/li>\n<li>joan Gil santano (vocal)<\/li>\n<li>Mar\u00eda  isabel Fabregat romero (vocal)<\/li>\n<li>Santiago Ambrosio viale (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rosa Ana Gonz\u00e1lez Polo Los objetivos que se plantearon para la realizaci\u00f3n de esta tesis doctoral fueron [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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