{"id":19483,"date":"2018-03-09T09:08:28","date_gmt":"2018-03-09T09:08:28","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-comparado-de-los-efectos-de-los-inhibidores-de-la-3hmg-co-a-reductasa-sobre-monocitos-y-celulas-propias-de-la-pared-vascular-cultivadas-in-vitro\/"},"modified":"2018-03-09T09:08:28","modified_gmt":"2018-03-09T09:08:28","slug":"estudio-comparado-de-los-efectos-de-los-inhibidores-de-la-3hmg-co-a-reductasa-sobre-monocitos-y-celulas-propias-de-la-pared-vascular-cultivadas-in-vitro","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-comparado-de-los-efectos-de-los-inhibidores-de-la-3hmg-co-a-reductasa-sobre-monocitos-y-celulas-propias-de-la-pared-vascular-cultivadas-in-vitro\/","title":{"rendered":"Estudio comparado de los efectos de los inhibidores de la 3hmg co-a reductasa sobre monocitos y c\u00e9lulas propias de la pared vascular cultivadas \u00abin vitro\u00bb"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Agudo De Blas Paloma <\/strong><\/h2>\n<p>Las estatinas, reducen los l\u00edpidos plasm\u00e1ticos, pero adem\u00e1s, parecen poseer otros efectos que inciden sobre la patogenia del proceso ateroscler\u00f3tico.  hip\u00f3tesis.  las estatinas deben tener efectos significativos sobre el comportamiento de las c\u00e9lulas que participan en el desarrollo de la placa de ateroma. dichos efectos pueden diferir en cada tipo celular y para cada estatina.  objetivos  1,- conocer los efectos que diferentes estatinas tienen \u00abin vitro\u00bb, sobre el comportamiento celular (adherencia, movilidad, proliferaci\u00f3n e inducci\u00f3n de apoptosis).  2,- conocer si tales efectos son c\u00e9lulas-dependientes o estatina-dependiente.  material y m\u00e9todos  c\u00e9lulas humanas: fibroblastos, musculares lisas de aorta, monocitos y c\u00e9lulas de endotelio vascular. Estatinas: atorvastatina (atv), cerivastatina (crv), lovastatina (lv), pravastatina (prv), y simvastatina (sv). T\u00e9cnicas: cultivo de tejidos, para estudiar (adherencia, movilidad, cin\u00e9tica de crecimiento e inducci\u00f3n de apoptosis). Tunel, fluorescencia con naranja a acridina\/bromuro de eetidio y dapi oara estudiar apoptosis. Faloidina- fluorescencia e inmunofluorescencia para el estudio de la actina.  resultados y discusi\u00f3n  la dl50 fue diferente para cada c\u00e9lula y cada estatina. La menor, para todas las c\u00e9lulas, fue para la crv (96 ng\/ml) y la mayor para la prv en monocitos (98.000 ng\/ml). Todas inhibieron la proliferaci\u00f3n e indujeron apoptosis en todas las c\u00e9lulas. Las c\u00e9lulas m\u00e1s sensibles fueron las endoteliales y las menos los monocitos y fibroblastos. La reducci\u00f3n de la movilidad fue significativa (p &lt;) en todas las c\u00e9lulas tratadas con crv y en las hmec-1 para todas las estatinas. Todas ellas producen p\u00e9rdida de aherencia, y alteraciones de las estructuras ricas en actina, disminuci\u00f3n de la actina f y aumento de la g.  conclusiones  la inhibici\u00f3n de la proliferaci\u00f3n y la movilidad, la inducci\u00f3n de apoptosis y la p\u00e9rdida de adherecnia son efect<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio comparado de los efectos de los inhibidores de la 3hmg co-a reductasa sobre monocitos y c\u00e9lulas propias de la pared vascular cultivadas \u00abin vitro\u00bb<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio comparado de los efectos de los inhibidores de la 3hmg co-a reductasa sobre monocitos y c\u00e9lulas propias de la pared vascular cultivadas \u00abin vitro\u00bb <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Agudo De Blas Paloma <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 15\/10\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ismael Alavarez Rodr\u00edguez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: domingo Espinos perez <\/li>\n<li>Manuel Jos\u00e9 Gayoso rodriguez (vocal)<\/li>\n<li>Manuel Oya otero (vocal)<\/li>\n<li>Luis alfonso Rico  zalba (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Agudo De Blas Paloma Las estatinas, reducen los l\u00edpidos plasm\u00e1ticos, pero adem\u00e1s, parecen poseer otros efectos que [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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