{"id":19495,"date":"2018-03-09T09:08:29","date_gmt":"2018-03-09T09:08:29","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-del-dominio-carboxi-terminal-del-receptor-de-glp-17-36amida\/"},"modified":"2018-03-09T09:08:29","modified_gmt":"2018-03-09T09:08:29","slug":"estudio-del-dominio-carboxi-terminal-del-receptor-de-glp-17-36amida","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-del-dominio-carboxi-terminal-del-receptor-de-glp-17-36amida\/","title":{"rendered":"Estudio del dominio carboxi-terminal del receptor de glp-1(7-36)amida"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Patricia V\u00e1zquez P\u00e9rez <\/strong><\/h2>\n<p>El p\u00e9ptido relacionado con el glucag\u00f3n de tipo 1 (glp-1), est\u00e1 implicado en muchas funciones biol\u00f3gicas, como son el aumento de al secreci\u00f3n de insulina dependiente de glucosa, as\u00ed como la estimaci\u00f3n de la presi\u00f3n arterial y producci\u00f3n de surfactante pulmonar. A nivel central el glp-1(7-36)amida estimula la liberaci\u00f3n selectiva de neurotransmisores y participa en la regulaci\u00f3n de procesos tales como la ingesta de alimentos y agua, la temperatura corporal y el control de ciertas funciones cardiovasculares. Su posible utilidad terape\u00fatica requiere un conocimiento detallado del funcionamiento y mecanismo de respuesta de este p\u00e9ptido tras su uni\u00f3n con su receptor.  el receptor del glp-1(7-36)amida, pertenece a la familia de receptores acoplados a prote\u00ednas g. En esta tesis se ha estudiado la implicaci\u00f3n del dominio carboxilo terminal del receptor de glp-1(7-36)amida en los procesos de uni\u00f3n al agonista, transducci\u00f3n de se\u00f1ales y endocitosis, mediante mutaciones puntuales o delecciones de este dominio citoplasm\u00e1tico del receptor.  de este trabajo se deduce que las mutaciones realizadas en el extremo carboxilo terminal no alteraron la afinidad del ligando por los receptores modificados. Este dominio interviene en la regulaci\u00f3n de la transducci\u00f3n de se\u00f1ales generadas desde el receptor, tanto la estimulaci\u00f3n de la adenilato ciclasa como la fosforilaci\u00f3n de miembros de la ruta de las mapk. Adem\u00e1s regiones concretas del extremo carboxi-terminal controlan los procesos endoc\u00edticos y regulan de manera positiva o negativa la internaci\u00f3n del receptor.  la mayor\u00eda de los receptores acoplados a prote\u00ednas g sufren modificaciones postraduccionales, la palmitoilaci\u00f3n de residuos de ciste\u00edna una de las m\u00e1s frecuentes. La sustituci\u00f3n de una ciste\u00edna del extremo carboxilo terminal del receptor de glp-1, que al igual que se describi\u00f3 para otros miembros de esta familia de receptores, podr\u00eda sufrir procesos de plamitoilaci\u00f3n<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio del dominio carboxi-terminal del receptor de glp-1(7-36)amida<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio del dominio carboxi-terminal del receptor de glp-1(7-36)amida <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Patricia V\u00e1zquez P\u00e9rez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/10\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Elvira Alvarez Garc\u00eda<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: enrique Bl\u00e1zquez fern\u00e1ndez <\/li>\n<li>isabel Valverde alonso (vocal)<\/li>\n<li>Juan  Emilio Feliu albi\u00f1ana (vocal)<\/li>\n<li>Luisa Villanueva-pe\u00f1acarrillo Mar\u00eda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Patricia V\u00e1zquez P\u00e9rez El p\u00e9ptido relacionado con el glucag\u00f3n de tipo 1 (glp-1), est\u00e1 implicado en muchas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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