{"id":19500,"date":"2018-03-09T09:08:30","date_gmt":"2018-03-09T09:08:30","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analisis-de-las-caractera%c2%adsticas-cla%c2%adnico-patologicas-diferenciales-de-los-tumores-colo-rectales-esporadicos-originados-por-la-va%c2%ada-supresora-y-la-via-mutadora\/"},"modified":"2018-03-09T09:08:30","modified_gmt":"2018-03-09T09:08:30","slug":"analisis-de-las-caractera%c2%adsticas-cla%c2%adnico-patologicas-diferenciales-de-los-tumores-colo-rectales-esporadicos-originados-por-la-va%c2%ada-supresora-y-la-via-mutadora","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analisis-de-las-caractera%c2%adsticas-cla%c2%adnico-patologicas-diferenciales-de-los-tumores-colo-rectales-esporadicos-originados-por-la-va%c2%ada-supresora-y-la-via-mutadora\/","title":{"rendered":"An\u00e1lisis de las caracter\u00edsticas cl\u00ednico-patol\u00f3gicas diferenciales de los tumores colo-rectales esporadicos originados por la v\u00edasupresora y la via mutadora"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Cristina Mart\u00ednez Santos <\/strong><\/h2>\n<p>Introducci\u00f3n  el c\u00e1ncer colorrectal (ccr) constituye un importante problema de salud p\u00fablica en nuestro medio. En los \u00faltimos a\u00f1os se han producido avances importantes en el conocimiento de la etiolog\u00eda del mismo. En cuanto a factores gen\u00e9ticos, sabemos que las distintas formas de ccr, tanto hereditarias como esp\u00f3radicas, pueden inducirse a trav\u00e9s de dos v\u00edas moleculares alternativas: la v\u00eda supresora y la v\u00eda mutadora. Creemos que es necesario continuar analizando las caracter\u00edsticas gen\u00e9ticas de los ccr en diversas poblaciones para establecer su verdadero valor pron\u00f3stico.  objetivos  1,- caracterizaci\u00f3n clinicopatol\u00f3gica de una serie de ccr espor\u00e1dicos de nuestra \u00e1rea.  2,- an\u00e1lisis de los genes implicados en la v\u00eda supresora y la v\u00eda mutadora en los tumores de la serie.  3,- an\u00e1lisis de las caracter\u00edsticas clinicopatol\u00f3gicas diferenciales de los tumores de la serie originados por la v\u00eda supresora y la v\u00eda mutadora.  pacientes y m\u00e9todos  se recogieron muestras de tumor y mucosa c\u00f3lica normal de 64 pacientes consecutivos intervenidos por ccr espor\u00e1dico en el servicio de cirug\u00eda general del hospital universitario de getafe a partir de septiembre de 1994. Se aisl\u00f3 el adn seg\u00fan el m\u00e9todo de extracci\u00f3n fen\u00f3lica y se midi\u00f3 su concentraci\u00f3n mediante espectofotometr\u00eda. Se amplific\u00f3 el material mediante pcr y los productos se separaron en electroforesis vertical de geles de acrilamida. Se analizaron la p\u00e9rdida de heterocigosidad (loh) de los genes apc,dcc, tp53 y d2s123 y la inestabilidad de microsat\u00e9lite (msi). Las alteraciones gen\u00e9ticas encontradas se relacionaron con la localizaci\u00f3n y caracter\u00edsticas histol\u00f3gicas del tumor, as\u00ed como los datos acerca de la evoluci\u00f3n de los pacientes, proces\u00e1ndose estad\u00edsticamente con el software spss.  resultados y conclusiones  1,- el 70% de los ccr son tratados quir\u00fargicamente con intenci\u00f3n curativa y de ellos el 25% recidivan.  2,- aunque los<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>An\u00e1lisis de las caracter\u00edsticas cl\u00ednico-patol\u00f3gicas diferenciales de los tumores colo-rectales esporadicos originados por la v\u00edasupresora y la via mutadora<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 An\u00e1lisis de las caracter\u00edsticas cl\u00ednico-patol\u00f3gicas diferenciales de los tumores colo-rectales esporadicos originados por la v\u00edasupresora y la via mutadora <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Cristina Mart\u00ednez Santos <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/10\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda no Moreno Azcoita<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Luis Balibrea  cantero <\/li>\n<li>Elena Fern\u00e1ndez ruiz (vocal)<\/li>\n<li>\u00e1ngel Su\u00e1rez Garc\u00eda (vocal)<\/li>\n<li>Juan  Manuel Bell\u00f3n caneiro (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Cristina Mart\u00ednez Santos Introducci\u00f3n el c\u00e1ncer colorrectal (ccr) constituye un importante problema de salud p\u00fablica en nuestro [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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