{"id":19507,"date":"2018-03-09T09:08:30","date_gmt":"2018-03-09T09:08:30","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/evaluacion-in-vivo-de-lactasa-intestinal-con-4-galactosil-xilosa-como-prueba-diagnostica-no-invasiva-de-la-deficiencia-de-este-enzima-ensayo-piloto-en-humanos\/"},"modified":"2018-03-09T09:08:30","modified_gmt":"2018-03-09T09:08:30","slug":"evaluacion-in-vivo-de-lactasa-intestinal-con-4-galactosil-xilosa-como-prueba-diagnostica-no-invasiva-de-la-deficiencia-de-este-enzima-ensayo-piloto-en-humanos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/evaluacion-in-vivo-de-lactasa-intestinal-con-4-galactosil-xilosa-como-prueba-diagnostica-no-invasiva-de-la-deficiencia-de-este-enzima-ensayo-piloto-en-humanos\/","title":{"rendered":"Evaluaci\u00f3n in vivo de lactasa intestinal con 4-galactosil-xilosa como prueba diagn\u00f3stica no invasiva de la deficiencia de este enzima. ensayo piloto en humanos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Carmen Hermida D\u00edaz <\/strong><\/h2>\n<p>Se ha optimizado la evaluaci\u00f3n in vivo de la actividad lactasa intestinal con 4-, 3- y 2- galactosil-xilosas mediante la determinaci\u00f3n colorim\u00e9trica de xilosa en orina tras la administraci\u00f3n oral del disac\u00e1rido sint\u00e9tico a ratas lactantes. De los compuestos examinados, 4-galactosil-xilosa fue el m\u00e1s eficaz para esta metodolog\u00eda, puesto que dio lugar a la m\u00e1xima correlaci\u00f3n (r=0,96) entre la variaci\u00f3n de la eliminaci\u00f3n de xilosa y la ca\u00edda fisiol\u00f3gica de la actividad lactasa con el destete de las ratas, siendo empleado a una dosis de 4 mg. El an\u00e1lisis de las caracter\u00edsticas cin\u00e9ticas del enzima de rata con las tres galactosil-xilosas empleadas ha permitido dar cuenta de su diferente comportamiento in vivo, encontr\u00e1ndose tambi\u00e9n que la 4-galactosil-xilosa es hidrolizada in vivo e in vitro en mayor proporci\u00f3n a nivel del centro activo para florizina que del centro para lactosa. La determinaci\u00f3n de xilosa en plasma, tras la administraci\u00f3n oral de 8 mg del disac\u00e1rido a ratas lactantes, permite evaluar el enzima in vivo con similar fiabilidad que en orina.  un ensayo piloto realizado en sujetos adultos tolerantes e intolerantes a la ingesta l\u00e1ctea ha evidenciado que esta metodolog\u00eda es v\u00e1lida para la evaluaci\u00f3n no invasiva en humanos de la actividad lactasa in vivo, siendo suficiente la ingesti\u00f3n de 250 mg de 4-galactosil-xilosa para poder detectar una reducci\u00f3n marcada de la excreci\u00f3n urinaria de xilosa en sujetos intolerantes. la actividad del enzima pudo tambi\u00e9n seguirse determinando la aparici\u00f3n de xilosa en plasma tras la ingesta de 3 g del disac\u00e1rido, objetiv\u00e1ndose su disminuci\u00f3n en un sujeto hipolact\u00e1sico. Ninguno de los sujetos estudiados present\u00f3 molestias tras el consumo de 4-galactosil-xilosa.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Evaluaci\u00f3n in vivo de lactasa intestinal con 4-galactosil-xilosa como prueba diagn\u00f3stica no invasiva de la deficiencia de este enzima. ensayo piloto en humanos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Evaluaci\u00f3n in vivo de lactasa intestinal con 4-galactosil-xilosa como prueba diagn\u00f3stica no invasiva de la deficiencia de este enzima. ensayo piloto en humanos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Carmen Hermida D\u00edaz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/10\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan  Jos\u00e9 Arag\u00f3n Reyes<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  jos\u00e9 V\u00e1zquez rodr\u00edguez <\/li>\n<li>ofelia Nieto l\u00f3pez (vocal)<\/li>\n<li>Juan  Emilio Feliu albinana (vocal)<\/li>\n<li>fermando Gonz\u00e1lez mateo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carmen Hermida D\u00edaz Se ha optimizado la evaluaci\u00f3n in vivo de la actividad lactasa intestinal con 4-, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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