{"id":19521,"date":"2018-03-09T09:08:31","date_gmt":"2018-03-09T09:08:31","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/control-de-la-decision-supervivencia-muerte-en-celulas-gliales-por-cannabinoides-papel-de-la-ceramida-y-la-protea%c2%adna-quinasa-b\/"},"modified":"2018-03-09T09:08:31","modified_gmt":"2018-03-09T09:08:31","slug":"control-de-la-decision-supervivencia-muerte-en-celulas-gliales-por-cannabinoides-papel-de-la-ceramida-y-la-protea%c2%adna-quinasa-b","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/control-de-la-decision-supervivencia-muerte-en-celulas-gliales-por-cannabinoides-papel-de-la-ceramida-y-la-protea%c2%adna-quinasa-b\/","title":{"rendered":"Control de la decisi\u00f3n supervivencia\/muerte en c\u00e9lulas gliales por cannabinoides: papel de la ceramida y la prote\u00edna quinasa b"},"content":{"rendered":"<h2>Tesis doctoral de <strong> M. Teresa G\u00f3mez Del Pulgar Garrote <\/strong><\/h2>\n<p>Los cannabinoides son los componentes activos de la planta cannabis sativa, popularmente conocida como marihuana. El descubrimiento de receptores espec\u00edficos para cannabinoides y de una familia de ligandos end\u00f3genos de los mismos ha estimulado extraordinariamente la investigaci\u00f3n acerca de estos compuestos en los \u00faltimos a\u00f1os. Una de estas \u00e1reas de investigaci\u00f3n ha estudiado la capacidad de los cannabinoides para controlar el destino celular. Acorde con ello, los resultados de la presente tesis doctoral indican que los cannabinoides desempe\u00f1an un papel dual en el control del destino de c\u00e9lulas gliales: por un lado, inducen la muerte de c\u00e9lulas transformadas (glioma), y por otro, protegen a las c\u00e9lulas no transformadas (astrocitos).  el efecto apopt\u00f3tico de los cannabinoides es selectivo de c\u00e9lulas gliales transformadas y depende de la generaci\u00f3n de ceramida, mediante la activaci\u00f3n de la principal enzima reguladora de la s\u00edntesis de novo de esfingol\u00edpidos, la serina palmitoitransferasa. La acumulaci\u00f3n de ceramida lleva a la activaci\u00f3n sostenida de la quinasa activada por se\u00f1ales extracelulares (erk) y a la inhibici\u00f3n de la prote\u00edna quinasa b (pkb). Debido a la falta de \u00e9xito de las terapias actuales en el tratamiento de gliomas es necesario desarrollar nuevas estrategias terap\u00e9uticas.  as\u00ed, nuestros datos indican que una de estas aproximaciones terap\u00e9uticas podr\u00eda ser el tratamiento con cannabionoides no psicoactivos, que inhiben el crecimiento del tumor in vivo sin efectos colaterales significativos.  adem\u00e1s, el tratamiento con cannabinoides no s\u00f3lo no afecta a la viabilidad de c\u00e9lulas gliales no transformadas, sino que en determinadas circunstancias las protege de la muerte. As\u00ed, estos compuestos son capaces de evitar la muerte de los astrocitos inducida por ceramida tanto in vitro como in vivo. el mecanismo de esta acci\u00f3n protectora implica la estimulaci\u00f3n coordinada de las rutas fosfoinos\u00edtido 3-quina<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Control de la decisi\u00f3n supervivencia\/muerte en c\u00e9lulas gliales por cannabinoides: papel de la ceramida y la prote\u00edna quinasa b<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Control de la decisi\u00f3n supervivencia\/muerte en c\u00e9lulas gliales por cannabinoides: papel de la ceramida y la prote\u00edna quinasa b <\/li>\n<li><strong>Autor:<\/strong>\u00a0 M. Teresa G\u00f3mez Del Pulgar Garrote <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/10\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel Guzm\u00e1n Pastor<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  isabel Fabregat romero <\/li>\n<li>carmen Guaza rodriguez (vocal)<\/li>\n<li> Lizcano de vega Jos\u00e9 Miguel (vocal)<\/li>\n<li> Merida de san roman isabel (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de M. Teresa G\u00f3mez Del Pulgar Garrote Los cannabinoides son los componentes activos de la planta cannabis sativa, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[6848,29273,59912,39707,14581,49715],"class_list":["post-19521","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-carmen-guaza-rodriguez","tag-lizcano-de-vega-jose-miguel","tag-m-teresa-gomez-del-pulgar-garrote","tag-manuel-guzman-pastor","tag-maria-isabel-fabregat-romero","tag-merida-de-san-roman-isabel"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/19521","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=19521"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/19521\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=19521"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=19521"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=19521"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}