{"id":19526,"date":"2018-03-09T09:08:32","date_gmt":"2018-03-09T09:08:32","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/influencia-de-la-hiperreactividad-bronquial-en-la-evolucion-de-los-enfermos-afectos-de-fibrosis-qua%c2%adstica\/"},"modified":"2018-03-09T09:08:32","modified_gmt":"2018-03-09T09:08:32","slug":"influencia-de-la-hiperreactividad-bronquial-en-la-evolucion-de-los-enfermos-afectos-de-fibrosis-qua%c2%adstica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/murcia\/influencia-de-la-hiperreactividad-bronquial-en-la-evolucion-de-los-enfermos-afectos-de-fibrosis-qua%c2%adstica\/","title":{"rendered":"Influencia de la hiperreactividad bronquial en la evoluci\u00f3n de los enfermos afectos de fibrosis qu\u00edstica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jos\u00e9 Valverde Molina <\/strong><\/h2>\n<p>Las sibilancias y la obstrucci\u00f3n bronquial forman parte de la sintomatolog\u00eda y patogenia de la fibrosis qu\u00edstica. La preValencia de s\u00edntomas relacionadas con el asma es elevada, tanto m\u00e1s cuanto mayor es el deterioro funcional de los pacientes. La hiperreactividad bronquial es una circunstancia prevalente entre los enfermos con fq y se ha asociado a diversos factores como la alteraci\u00f3n de la funci\u00f3n pulmonar, la existencia de atopia o el deterioro cl\u00ednico. Incluso se ha publicado que puede resultar un factor de mal pron\u00f3stico en esta enfermedad. Hemos realizado un estudio en 2 fases sobre hiperreactividad bronquial en fq en 32 pacientes mediante test de broncoprovocaci\u00f3n farmacol\u00f3gica inespec\u00edfica directa con histamina, a dosis m\u00e1xima de 8mg\/ml, administrada mediante dos\u00edmetro mefar-b3. Hemos considerado prueba positiva la caida &gt;20% del fev1 basal. Un 28,1% de los pacientes respondieron positivamente al test. En la fase 1, esta respuesta se asoci\u00f3 de una forma estad\u00edsticamente significativa (p&lt;0,05) con una peor funci\u00f3n pulmonar, peores scores cl\u00ednico (shwachman) y radiol\u00f3gico (chrispin-norman), y a la existencia de colonizaci\u00f3n bacteriana cr\u00f3nica (tanto m\u00e1s cuanto mayor deterioro de fev1); no en contrando relaci\u00f3n con el tipo de mutaci\u00f3n gen\u00e9tica (f508del) o atopia (determinada mediante realizaci\u00f3n de prick-test). Tres pacientes fueron sometidos a transplante pulmonar en este periodo de estudio. En el resto, 29 casos, en una segunda fase se estudi\u00f3 la evoluci\u00f3n durante 4 a\u00f1os sin que pudiera demostrarse que la hiperreactividad bronquial determinara un mayor deterioro funcional cl\u00ednico ni radiol\u00f3gico; tampoco encontrados diferencias estad\u00edsticamente significativas en el n\u00c2\u00ba de exacerbaciones cl\u00ednicas. As\u00ed pues, concluimos que no hemos encontrado que la presencia de hiperrespuesta bronquial en la fq sea un factor de mal pron\u00f3stico en la evoluci\u00f3n de los enfermos. creemos que esta hiperreactividad bro<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Influencia de la hiperreactividad bronquial en la evoluci\u00f3n de los enfermos afectos de fibrosis qu\u00edstica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Influencia de la hiperreactividad bronquial en la evoluci\u00f3n de los enfermos afectos de fibrosis qu\u00edstica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jos\u00e9 Valverde Molina <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/10\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel S\u00e1nchez Sol\u00eds Querol<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: rafael Jimenez gonzalez <\/li>\n<li>Francisco Javier P\u00e9rez fr\u00edas (vocal)<\/li>\n<li>martin Navarro merino (vocal)<\/li>\n<li>Fernando S\u00e1nchez gasc\u00f3n (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jos\u00e9 Valverde Molina Las sibilancias y la obstrucci\u00f3n bronquial forman parte de la sintomatolog\u00eda y patogenia de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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