{"id":19604,"date":"2018-03-09T09:08:38","date_gmt":"2018-03-09T09:08:38","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/modulation-of-na-k-atpase-activity-by-agonists-of-mu-opioid-receptors-and-its-role-in-their-antinociceptive-effects\/"},"modified":"2018-03-09T09:08:38","modified_gmt":"2018-03-09T09:08:38","slug":"modulation-of-na-k-atpase-activity-by-agonists-of-mu-opioid-receptors-and-its-role-in-their-antinociceptive-effects","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/modulation-of-na-k-atpase-activity-by-agonists-of-mu-opioid-receptors-and-its-role-in-their-antinociceptive-effects\/","title":{"rendered":"Modulation of na+, k+ -atpase activity by agonists of mu-opioid receptors and its role in their antinociceptive effects"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Willias Masocha <\/strong><\/h2>\n<p>Introducci\u00f3n  se ha demostrado que la morfina estimula la actividad de la na+, k+ -atpasa cerebral. Sin embargo, los mecanismos moleculares implicados en estos efectos (tales como el papel de los receptores opioides y las prote\u00ednas g) no se conocen bien. Por otro lado, algunos investigadores no han detectado el efecto estimulante de la morfina en la na+, k+ -atpasa in vitro, lo que podr\u00eda ser debido al uso de condiciones experimentales diferentes.  objetivos  el primer objetivo fue caracterizar las condiciones optimas de trabajo para valorar la actividad de la na+, k+ -atpasa en sinaptosomas cerebrales in vitro y valorar los efectos de la morfina en ella.  el segundo objetivo fue comparar los efectos de la morfina sobre la actividad de la na+, k+ -atpasa con los de otros agonistas opioides u.  el tercer objetivo fue evaluar la modulaci\u00f3n producida por la naloxona, antagonistas selectivos de los receptores opioides u y bloqueantes de las prote\u00ednas g i\/o sobre los efectos inducidos por los agonistas opioides u en la na+, k+ -atpasa.  el cuarto objetivo fue estudiar in vivo la modulaci\u00f3n producida por los bloqueantes de la na+, k+, -atpasa (ouaba\u00edna, digoxina y digitoxina) de un antinocicepci\u00f3n inducida por los agonistas opioides u.  m\u00e9todos  todos los experimentos se realizaron con ratones hembras cd-1 swiss (charles river) de peso comprendido entre 25 y 30 g. Los animales fueron tratados de acuerdo con las directrices de la uni\u00f3n europea para el cuidado de los animales de laboratorio (directiva 86\/609) y las normas \u00e9ticas para la investigaci\u00f3n del dolor en animales conscientes.  la actividad de la na+, k+ -atpasa sensible a la ouaba\u00edna fue medida en sinaptosomas del cerebro anterior de rat\u00f3n y fue calculada como la diferencia entre la actividad total y la insensible a ouaba\u00edna (1mm). Para hallar la actividad de la na+, k+ -atpasa, se recurre indirectamente a la concentraci\u00f3n del fosfato inorg\u00e1nico liberado por l<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Modulation of na+, k+ -atpase activity by agonists of mu-opioid receptors and its role in their antinociceptive effects<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Modulation of na+, k+ -atpase activity by agonists of mu-opioid receptors and its role in their antinociceptive effects <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Willias Masocha <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Granada<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 24\/10\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Manuel Baeyens Cabrera<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Luisa Ugedo urruela <\/li>\n<li>milagros Gallo torre (vocal)<\/li>\n<li>Juan  Manuel Duarte p\u00e9rez (vocal)<\/li>\n<li>carmen Mar\u00eda Gonzalez garcia (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Willias Masocha Introducci\u00f3n se ha demostrado que la morfina estimula la actividad de la na+, k+ -atpasa [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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