{"id":19616,"date":"2018-03-09T09:08:39","date_gmt":"2018-03-09T09:08:39","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/regulacion-de-la-muerte-celular-programada-en-el-desarrollo-del-oa%c2%addo-interno\/"},"modified":"2018-03-09T09:08:39","modified_gmt":"2018-03-09T09:08:39","slug":"regulacion-de-la-muerte-celular-programada-en-el-desarrollo-del-oa%c2%addo-interno","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/regulacion-de-la-muerte-celular-programada-en-el-desarrollo-del-oa%c2%addo-interno\/","title":{"rendered":"Regulaci\u00f3n de la muerte celular programada en el desarrollo del o\u00eddo interno"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Susana Ca\u00f1on S\u00e1nchez <\/strong><\/h2>\n<p>Este trabajo explora los mecanismos de se\u00f1alizaci\u00f3n intracelular implicados en la apoptosis inducida por el factor de crecimiento nervioso (ngf) durante el desarrollo del o\u00eddo interno del embri\u00f3n de pollo y su interacci\u00f3n con las se\u00f1ales de supervivencia activadas por el factor de crecimiento tipo insulina-1 (igf-i).  el ngf y las neurotrofinas, inducen la supervivencia celular a trav\u00e9s de la activaci\u00f3n de sus receptores de alta afinidad (trk), pero tambi\u00e9n se unen al receptor de baja afinidad p75ntr, un modulador de la muerte y supervivencia celulares. Ambos tipos de receptores se expresan en la ves\u00edcula \u00f3tica (vo) y en el ganglio c\u00f3cleo-vestibular (gcv). La muerte inducida por ngf, tras su uni\u00f3n a p75ntr, ocurre en \u00e1reas muy espec\u00edficas de la ov y del gcv, sugiriendo la existencia de una estricta regulaci\u00f3n de las acciones del ngf. Este mecanismo de apoptosis desencadenado por ngf implica una serie de procesos que incluyen la generaci\u00f3n de ceramida (por activaci\u00f3n de la esfingomielinasa \u00e1cida y por la s\u00edntesis de novo), la activaci\u00f3n de caspasas y la fragmentaci\u00f3n de la poli-adp-ribosa polimerasa (parp).  el igf-i promueve el crecimiento celular y la supervivencia en el o\u00eddo interno, y est\u00e1 presente, junto a su receptor (igfr), en la vo y el gcv durante el desarrollo temprano del o\u00eddo, al igual que ocurre con la insulina y su receptor. El igf-i induce supervivencia protegiendo a la vo de la muerte inducida por deprevaci\u00f3n de suero, por ngf o por ceramida ex\u00f3gena, actuando a distintos niveles: primero, bloqueando el incremento en los niveles de ceramida end\u00f3gena y segundo, activando akt. Nuestros rsultados demuestran que el igf-i act\u00faa, adem\u00e1s, induciendo la conversi\u00f3n de la ceramida en su metabolismo fosforilado, ceramida-1-p, de efecto citoprotector.  los experimentos in vivo realizados sobreexpresando p75ntr en embriones de pollo (mediante fibroblastos transfectados con vectores retrovirales) o bloquea<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Regulaci\u00f3n de la muerte celular programada en el desarrollo del o\u00eddo interno<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Regulaci\u00f3n de la muerte celular programada en el desarrollo del o\u00eddo interno <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Susana Ca\u00f1on S\u00e1nchez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 24\/10\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Isabel Varela Nieto<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jorgina Satr\u00fastegui gil-delgado <\/li>\n<li>domingos Henrique (vocal)<\/li>\n<li>Mar\u00eda Frade jos\u00e9 (vocal)<\/li>\n<li> Rosa enrique de la (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Susana Ca\u00f1on S\u00e1nchez Este trabajo explora los mecanismos de se\u00f1alizaci\u00f3n intracelular implicados en la apoptosis inducida por [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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