{"id":19660,"date":"2018-03-09T09:08:43","date_gmt":"2018-03-09T09:08:43","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/fisiologa%c2%ada-molecular-de-gap-43-una-protea%c2%adna-implicada-en-extension-y-gua%c2%ada-axonal\/"},"modified":"2018-03-09T09:08:43","modified_gmt":"2018-03-09T09:08:43","slug":"fisiologa%c2%ada-molecular-de-gap-43-una-protea%c2%adna-implicada-en-extension-y-gua%c2%ada-axonal","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/fisiologa%c2%ada-molecular-de-gap-43-una-protea%c2%adna-implicada-en-extension-y-gua%c2%ada-axonal\/","title":{"rendered":"Fisiolog\u00eda molecular de gap-43: una prote\u00edna implicada en extensi\u00f3n y gu\u00edaaxonal"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Noa Beatriz Mart\u00edn C\u00f3freces <\/strong><\/h2>\n<p>Gap-43 es una prote\u00edna espec\u00edfica de tejido nervioso. Su periodo de expresi\u00f3n durante el desarrollo coincide con la ventana de tiempo en que se produce la diferenciaci\u00f3n neuronal y elongaci\u00f3n de axones, descendiendo cuando se comienza la sinaptog\u00e9nesis. Su expresi\u00f3n tambi\u00e9n aumenta en procesos de regeneraci\u00f3n tras lesiones en sistema nervioso. Su funci\u00f3n ha sido relacionada con extensi\u00f3n y gu\u00eda axonal debido a fallos en la formaci\u00f3n de distintos sistemas organizativos en ratones que no expresan gap-43 (knock-out). As\u00ed mismo, se ha propuesto tambi\u00e9n un papel en plasticidad neuronal, dada su expresi\u00f3n en zonas de alta plasticidad en el adulto (hipocampo, bublo ilfatorio, neocortex), y su relaci\u00f3n con procesos de memoria (ltp).  se han realizado numerosos esfuerzos para asignar a gap-43 una funci\u00f3n a nivel molecular que explique los cambios en el citoesqueleto de actina que parecen debidos a su expresi\u00f3n en l\u00edneas celulares, neuronales o no. sin embargo, a\u00fan no se conoce su funci\u00f3n.  el objetivo de esta tesis fue continuar con el estudio de gap-43, procurando asignar un papel a cada una de las regiones de gap-43. Para ello se obtuvieron distintos mutantes de delecci\u00f3n de la prote\u00edna, y se expresaron en c\u00e9lulas de tipo fibroblasto y epitelial. Con ellos se ha estudiado la distribuci\u00f3n subcelular de gap-43, como su capacidad de inducir filopodios. Se ha visto que gap-43 necesita se extremo amino terminal para localizarse en membrana plasm\u00e1tica, aunque su extremo carboxilo terminal permite que se localice en zonas de alta din\u00e1mica de actina, como son los frentes de avance de lamelipodios. Por otro lado, el dominio iq es capaz de interaccionar con membrana plasm\u00e1tica, aunque no es determinante para la localizaci\u00f3n de gap-43. Esta localizaci\u00f3n en membrana permite la codistribuci\u00f3n de gap-43 con prote\u00edna simplicadas en adhesi\u00f3n c\u00e9lula-c\u00e9lula en c\u00e9lulas epiteliales, como son e-cadherinas y beta-catenina, estudia<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Fisiolog\u00eda molecular de gap-43: una prote\u00edna implicada en extensi\u00f3n y gu\u00edaaxonal<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Fisiolog\u00eda molecular de gap-43: una prote\u00edna implicada en extensi\u00f3n y gu\u00edaaxonal <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Noa Beatriz Mart\u00edn C\u00f3freces <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 25\/10\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Javier Diez Guerra<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: federico Mayor menendez <\/li>\n<li> Felipe oroquieta Javierde (vocal)<\/li>\n<li>carmen Arag\u00f3n rueda (vocal)<\/li>\n<li>Jos\u00e9 S\u00e1nchez-prieto borja (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Noa Beatriz Mart\u00edn C\u00f3freces Gap-43 es una prote\u00edna espec\u00edfica de tejido nervioso. Su periodo de expresi\u00f3n durante [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[5283,6285,29974,60260,6729,60259],"class_list":["post-19660","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-carmen-aragon-rueda","tag-federico-mayor-menendez","tag-felipe-oroquieta-javierde","tag-francisco-javier-diez-guerra","tag-jose-sanchez-prieto-borja","tag-noa-beatriz-martin-cofreces"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/19660","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=19660"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/19660\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=19660"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=19660"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=19660"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}