{"id":19661,"date":"2018-03-09T09:08:43","date_gmt":"2018-03-09T09:08:43","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/produccion-de-anticuerpos-monoclonales-en-ratones-transgenicos\/"},"modified":"2018-03-09T09:08:43","modified_gmt":"2018-03-09T09:08:43","slug":"produccion-de-anticuerpos-monoclonales-en-ratones-transgenicos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/produccion-de-anticuerpos-monoclonales-en-ratones-transgenicos\/","title":{"rendered":"Producci\u00f3n de anticuerpos monoclonales en ratones transg\u00e9nicos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Eduardo Su\u00e1rez Garc\u00eda De Las Heras <\/strong><\/h2>\n<p>El trabajo presentado contiene una comparaci\u00f3n entre cepas de ratones que portan distintas combinaciones de transgenes humanos. Se estudia la expresi\u00f3n de genes de inmunoglobulinas humanas en los ratones transg\u00e9nicos y en hibridomas obtenidos de esplenocitos de animales inmunizados, determin\u00e1ndose las pautas de variabilidad mutacional y la utilizaci\u00f3n de mecanismos de variabilidad en la construcci\u00f3n del repertorio humano. Se determinaron las condiciones \u00f3ptimas para la obtenci\u00f3n de anticuerpos monoclonales de naturaleza humana que reaccionan con una serie de ant\u00edgenos de inter\u00e9s, caracteriz\u00e1ndose algunas de sus propiedades as\u00ed como su especificidad en el contexto de la inmunizaci\u00f3n idiot\u00edpica. El m\u00e9todo general se valida al estudiar el reconocimiento espec\u00edfico de c\u00e9lulas tumorales portadoras del idiotipo.  las conclusiones del trabajo permiten destacar la utilizaci\u00f3n de mecanismos generales en la configuraci\u00f3n del repertorio humano a pesar de la evidencias halladas de un un uso restringido de ciertas familias g\u00e9nicas. La aplicaci\u00f3n del m\u00e9todo a la obtenci\u00f3n de reactivos que reconocen y destruyen in vitro c\u00e9lulas tumorales permite augurar su empleo futuro en la terapia humana.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Producci\u00f3n de anticuerpos monoclonales en ratones transg\u00e9nicos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Producci\u00f3n de anticuerpos monoclonales en ratones transg\u00e9nicos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Eduardo Su\u00e1rez Garc\u00eda De Las Heras <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 25\/10\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Fernando Diaz Espada Lorenzo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: valent\u00edn Cuerdas-mons Martinez <\/li>\n<li>africa Gonz\u00e1lez fern\u00e1ndez (vocal)<\/li>\n<li> Ortiz de camdazuri busca Manuel (vocal)<\/li>\n<li> Pablo d\u00edaz rosario de (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Eduardo Su\u00e1rez Garc\u00eda De Las Heras El trabajo presentado contiene una comparaci\u00f3n entre cepas de ratones que [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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